HRTSvsIXJETF Comparison
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Tema GLP-1, Obesity & Cardiometabolic ETF (HRTS) belongs to the Tomorrow's Treatments segment. iShares Global Healthcare ETF (IXJ) is part of the Global Large Cap segment. Both ETFs have the same top 3 sector exposures: and Healthcare. HRTS is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.4% for IXJ. HRTS is up 4.32% year-to-date (YTD) with -$2M in YTD flows. IXJ performs better with 4.9% YTD performance, and -$530M in YTD flows. Run a side-by-side ETF comparison of HRTS and IXJ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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HRTS vs IXJ performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/30/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | HRTS IXJ | +1.63%+2.87% | +9.49%+9.83% | +4.32%+4.90% | +31.36%+20.30% | n/a+23.01% | n/a+26.12% |
| Flows | HRTS IXJ | -+$175M | -$70K+$199M | -$2M-$530M | -$6M-$281M | --$520M | -+$195M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | HRTS IXJ | +17.44%+17.32% | +16.04%+15.40% | n/a+13.91% | n/a+14.35% |
| Max drawdown | HRTS IXJ | -4.69%-3.91% | -10.68%-10.83% | n/a-18.04% | n/a-18.04% |
| Max drawdown duration | HRTS IXJ | 23d22d | 170d122d | n/a490d | n/a490d |
Trading data
HRTS | IXJ | |
Last sale 7/31/2026 at 1:30 PM | $36.43 | $100.26 |
| Previous close 07/30/2026 | $36.90 | $101.24 |
| Consolidated volume 07/30/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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HRTS
is actively managed and doesn’t replicate an indexHRTS | IXJ | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 7/31/2026 at 1:30 PM
Live
Closed
HRTS | IXJ | |
|---|---|---|
| Last price | $36.43 | $100.26 |
| 1D performance | -1.26% | -0.97% |
| AuM | $54.92 M | $4.13 B |
| E/R | 0.99% | 0.4% |
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Exposure
Countries
HRTS
USA
76.55%
Switzerland
7.26%
Other
16.19%
IXJ
USA
69.49%
Switzerland
10.37%
Other
20.14%
Sectors
HRTS
Healthcare
99.57%
Other
0.43%
IXJ
Healthcare
96.99%
Other
3.01%
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Diversification
HRTS
Total weight of top 15 holdings out of 15
64.29%
IXJ
Total weight of top 15 holdings out of 15
57.47%
Top 15 holdings
Data as of June 30, 2026
HRTS
Eli Lilly & Co.
11.91%
UnitedHealth Group, Inc.
5.58%
Novo Nordisk A/S
5.25%
Merck & Co., Inc.
4.11%
Roche Holding AG
3.96%
Thermo Fisher Scientific, Inc.
3.91%
AstraZeneca PLC
3.85%
Johnson & Johnson
3.84%
Revolution Medicines, Inc.
3.64%
Cytokinetics, Inc.
3.40%
Novartis AG
3.30%
Gilead Sciences, Inc.
3.09%
Vertex Pharmaceuticals, Inc.
3.04%
Abbott Laboratories
2.71%
Danaher Corp.
2.70%
IXJ
Eli Lilly & Co.
10.92%
Johnson & Johnson
7.04%
AbbVie, Inc.
5.12%
UnitedHealth Group, Inc.
4.39%
Merck & Co., Inc.
4.12%
AstraZeneca PLC
3.77%
Roche Holding AG
3.76%
Novartis AG
3.73%
Amgen, Inc.
2.54%
Thermo Fisher Scientific, Inc.
2.42%
Abbott Laboratories
2.05%
Gilead Sciences, Inc.
2.03%
Novo Nordisk A/S
1.99%
Intuitive Surgical, Inc.
1.83%
Pfizer Inc.
1.78%
Frequently asked questions about HRTS and IXJ
How have the HRTS and IXJ ETFs performed in 2026?
As of July 30, 2026, HRTS is up 4.32% year-to-date (YTD), while IXJ has returned 4.9%. That puts IXJ better performer ahead so far this year.
Which ETF is attracting more investor money: HRTS or IXJ?
Year-to-date, the HRTS ETF saw -$2M in flows, compared to -$530M for IXJ.
Which ETF is more volatile: HRTS or IXJ?
Over the past year, HRTS had a volatility of 16.04%, while IXJ experienced 15.4%.
Which ETF is bigger: HRTS or IXJ?
As of July 30, 2026, HRTS holds $54.92 M in assets under management (AUM), while IXJ manages $4.13 B.
What sectors do the HRTS and IXJ ETFs invest in?
HRTS leans toward sectors like Healthcare. Meanwhile, IXJ focuses on Healthcare.
What are the top holdings of the HRTS ETF and IXJ ETF?
HRTS top holdings include Eli Lilly & Co., UnitedHealth Group, Inc. and Novo Nordisk A/S. IXJ holds in its top three: Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc..
Which ETF is more diversified: HRTS or IXJ?
HRTS holds 43 securities with 64.29% of its assets in the top 15. IXJ has 111 securities and a top 15 weight of 57.47%.
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Latest news about HRTS & IXJ
Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?
April 18, 2024
HRTS
Healthcare Funds on the Rise
January 9, 2024
IXJ
Healthcare Stocks Rebound
August 14, 2023
IXJ
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Continued tightening of the U.S. labor market
September 23, 2022
IXJ
Continued tightening of the U.S. labor market
September 23, 2022
IXJ
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