HRTSvsIXJETF Comparison
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Tema GLP-1, Obesity & Cardiometabolic ETF (HRTS) belongs to the Tomorrow's Treatments segment. iShares Global Healthcare ETF (IXJ) is part of the Global Large Cap segment. Both ETFs have the same top 3 sector exposures: and Health Care. HRTS is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.4% for IXJ. HRTS is down -5.16% year-to-date (YTD) with -$2M in YTD flows. IXJ performs better with -5.09% YTD performance, and -$729M in YTD flows. Run a side-by-side ETF comparison of HRTS and IXJ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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HRTS vs IXJ performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 05/01/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | HRTS IXJ | -1.32%-2.25% | -6.82%-7.08% | -5.16%-5.09% | +18.38%+7.74% | n/a+11.22% | n/a+22.79% |
| Flows | HRTS IXJ | -$1M+$19M | -$4M-$784M | -$2M-$729M | -$12M-$450M | --$1.07B | -+$201M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | HRTS IXJ | +17.14%+15.89% | +16.35%+15.38% | n/a+13.31% | n/a+13.98% |
| Max drawdown | HRTS IXJ | -9.68%-10.83% | -10.68%-10.83% | n/a-18.04% | n/a-18.04% |
| Max drawdown duration | HRTS IXJ | 61d61d | 114d61d | n/a490d | n/a490d |
Trading data
HRTS | IXJ | |
Last sale 5/1/2026 at 1:30 PM | $33.55 | $92.41 |
| Previous close 04/29/2026 | $33.66 | $92.93 |
| Consolidated volume 04/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of April 30, 2026
1-year trailing difference
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HRTS
is actively managed and doesn’t replicate an indexHRTS | IXJ | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 5/1/2026 at 1:30 PM
Live
Closed
HRTS | IXJ | |
|---|---|---|
| Last price | $33.55 | $92.41 |
| 1D performance | -0.33% | -0.56% |
| AuM | $49.93 M | $3.59 B |
| E/R | 0.99% | 0.4% |
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Exposure
Countries
HRTS
USA
82.47%
Other
17.53%
IXJ
USA
68.5%
Switzerland
10.22%
Other
21.28%
Sectors
HRTS
Health Care
87.86%
Other
12.14%
IXJ
Health Care
90.51%
Other
9.49%
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Diversification
HRTS
Total weight of top 15 holdings out of 15
61.52%
IXJ
Total weight of top 15 holdings out of 15
56.56%
Top 15 holdings
Data as of March 31, 2026
HRTS
LILLY
9.70%
JOHNSON&JOHNSON
4.97%
US7711951043
4.94%
ASTRAZENECA
4.91%
MERCK & CO INC
4.46%
THERMO FISHER SCIENTIFIC
4.06%
UNITEDHEALTH GRP
3.79%
GILEAD SCIENCES
3.66%
NOVARTIS
3.52%
VERTEX PHARMACEUTICALS
3.30%
ABBOTT LABS
3.26%
ABBVIE
3.00%
BRIDGEBIO PHARMA
2.85%
DANAHER
2.81%
BRISTOL-MYERS SQUIBB
2.29%
IXJ
LILLY
9.50%
JOHNSON&JOHNSON
7.68%
ABBVIE
5.01%
ASTRAZENECA
4.01%
MERCK & CO INC
3.98%
NOVARTIS
3.81%
CH1499059983
3.67%
UNITEDHEALTH GRP
3.27%
AMGEN-T
2.53%
THERMO FISHER SCIENTIFIC
2.46%
ABBOTT LABS
2.38%
GILEAD SCIENCES
2.31%
INTUITIVE SURGICAL
2.18%
PFIZER
2.13%
BRISTOL-MYERS SQUIBB
1.65%
Frequently asked questions about HRTS and IXJ
How have the HRTS and IXJ ETFs performed in 2026?
As of May 1, 2026, HRTS is down -5.16% year-to-date (YTD), while IXJ has lost -5.09%. That puts IXJ better performer ahead so far this year.
Which ETF is attracting more investor money: HRTS or IXJ?
Year-to-date, the HRTS ETF saw -$2M in flows, compared to -$729M for IXJ.
Which ETF is more volatile: HRTS or IXJ?
Over the past year, HRTS had a volatility of 16.35%, while IXJ experienced 15.38%.
Which ETF is bigger: HRTS or IXJ?
As of May 1, 2026, HRTS holds $49.93 M in assets under management (AUM), while IXJ manages $3.59 B.
What sectors do the HRTS and IXJ ETFs invest in?
HRTS leans toward sectors like Health Care. Meanwhile, IXJ focuses on Health Care.
What are the top holdings of the HRTS ETF and IXJ ETF?
HRTS top holdings include LILLY, JOHNSON&JOHNSON and US7711951043. IXJ holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.
Which ETF is more diversified: HRTS or IXJ?
HRTS holds 44 securities with 61.52% of its assets in the top 15. IXJ has 114 securities and a top 15 weight of 56.56%.
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Latest news about HRTS & IXJ
Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?
April 18, 2024
HRTS
Healthcare Funds on the Rise
January 9, 2024
IXJ
Healthcare Stocks Rebound
August 14, 2023
IXJ
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Continued tightening of the U.S. labor market
September 23, 2022
IXJ
Continued tightening of the U.S. labor market
September 23, 2022
IXJ
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