HRTSvsAGNGETF Comparison
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Tema GLP-1, Obesity & Cardiometabolic ETF (HRTS) belongs to the Tomorrow's Treatments segment. Global X Aging Population ETF (AGNG) is part of the New Consumers & Focus segment. Both ETFs have the same top 3 sector exposures: and Healthcare. HRTS is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.5% for AGNG. HRTS is up 4.32% year-to-date (YTD) with -$2M in YTD flows. AGNG performs better with 4.95% YTD performance, and +$13M in YTD flows. Run a side-by-side ETF comparison of HRTS and AGNG below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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HRTS vs AGNG performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/30/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | HRTS AGNG | +1.63%+4.11% | +9.49%+7.07% | +4.32%+4.95% | +31.36%+16.31% | n/a+37.15% | n/a+28.43% |
| Flows | HRTS AGNG | -- | -$70K+$692K | -$2M+$13M | -$6M+$18M | -+$23M | -+$13M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | HRTS AGNG | +17.44%+14.86% | +16.04%+13.13% | n/a+12.28% | n/a+13.80% |
| Max drawdown | HRTS AGNG | -4.69%-4.89% | -10.68%-11.18% | n/a-13.73% | n/a-25.40% |
| Max drawdown duration | HRTS AGNG | 23d31d | 170d151d | n/a323d | n/a1041d |
Trading data
HRTS | AGNG | |
Last sale 7/31/2026 at 1:30 PM | $36.43 | $37.19 |
| Previous close 07/30/2026 | $36.90 | $37.56 |
| Consolidated volume 07/30/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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HRTS
is actively managed and doesn’t replicate an indexHRTS | AGNG | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 7/31/2026 at 1:30 PM
Live
Closed
HRTS | AGNG | |
|---|---|---|
| Last price | $36.43 | $37.19 |
| 1D performance | -1.26% | -0.99% |
| AuM | $54.92 M | $87.98 M |
| E/R | 0.99% | 0.5% |
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Exposure
Countries
HRTS
USA
76.55%
Switzerland
7.26%
Other
16.19%
AGNG
USA
55.01%
Switzerland
13.28%
Other
31.7%
Sectors
HRTS
Healthcare
99.57%
Other
0.43%
AGNG
Healthcare
90.38%
Finance
9.07%
Other
0.55%
Diversification
HRTS
Total weight of top 15 holdings out of 15
64.29%
AGNG
Total weight of top 15 holdings out of 15
47.54%
Top 15 holdings
Data as of June 30, 2026
HRTS
Eli Lilly & Co.
11.91%
UnitedHealth Group, Inc.
5.58%
Novo Nordisk A/S
5.25%
Merck & Co., Inc.
4.11%
Roche Holding AG
3.96%
Thermo Fisher Scientific, Inc.
3.91%
AstraZeneca PLC
3.85%
Johnson & Johnson
3.84%
Revolution Medicines, Inc.
3.64%
Cytokinetics, Inc.
3.40%
Novartis AG
3.30%
Gilead Sciences, Inc.
3.09%
Vertex Pharmaceuticals, Inc.
3.04%
Abbott Laboratories
2.71%
Danaher Corp.
2.70%
AGNG
Novo Nordisk A/S
3.84%
Eli Lilly & Co.
3.82%
AbbVie, Inc.
3.57%
Edwards Lifesciences Corp.
3.42%
Welltower, Inc.
3.29%
Johnson & Johnson
3.19%
Merck & Co., Inc.
3.13%
Ventas, Inc.
3.11%
Roche Holding AG
3.05%
Amgen, Inc.
3.01%
Bristol Myers Squibb Co.
2.92%
Stryker Corp.
2.88%
UCB SA
2.81%
AstraZeneca PLC
2.76%
Medtronic Plc
2.73%
Frequently asked questions about HRTS and AGNG
How have the HRTS and AGNG ETFs performed in 2026?
As of July 30, 2026, HRTS is up 4.32% year-to-date (YTD), while AGNG has returned 4.95%. That puts AGNG better performer ahead so far this year.
Which ETF is attracting more investor money: HRTS or AGNG?
Year-to-date, the HRTS ETF saw -$2M in flows, compared to +$13M for AGNG.
Which ETF is more volatile: HRTS or AGNG?
Over the past year, HRTS had a volatility of 16.04%, while AGNG experienced 13.13%.
Which ETF is bigger: HRTS or AGNG?
As of July 30, 2026, HRTS holds $54.92 M in assets under management (AUM), while AGNG manages $87.98 M.
What sectors do the HRTS and AGNG ETFs invest in?
HRTS leans toward sectors like Healthcare. Meanwhile, AGNG focuses on Healthcare and Finance.
What are the top holdings of the HRTS ETF and AGNG ETF?
HRTS top holdings include Eli Lilly & Co., UnitedHealth Group, Inc. and Novo Nordisk A/S. AGNG holds in its top three: Novo Nordisk A/S, Eli Lilly & Co. and AbbVie, Inc..
Which ETF is more diversified: HRTS or AGNG?
HRTS holds 43 securities with 64.29% of its assets in the top 15. AGNG has 84 securities and a top 15 weight of 47.54%.
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Latest news about HRTS & AGNG
Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?
April 18, 2024
HRTS
Investing in the Aging Demographics Megatrend
February 28, 2023
AGNG
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