BBCvsXPHETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. State Street SPDR S&P Pharmaceuticals ETF (XPH) is part of the US Health Care segment. Both ETFs have the same top 1 sector exposures: Healthcare. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.35% for XPH. BBC is up 27.77% year-to-date (YTD) with +$5M in YTD flows. XPH performs worse with 20.76% YTD performance, and +$296M in YTD flows. Run a side-by-side ETF comparison of BBC and XPH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs XPH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC XPH | -5.78%-2.99% | +17.22%+13.04% | +27.77%+20.76% | +102.82%+42.98% | +137.50%+62.03% | +6.45%+50.40% |
| Flows | BBC XPH | -+$93M | +$83K+$188M | +$5M+$296M | +$12M+$318M | +$16M+$257M | +$8M+$264M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC XPH | +33.39%+22.49% | +36.22%+22.63% | +37.22%+20.52% | +39.64%+20.88% |
| Max drawdown | BBC XPH | -11.65%-8.78% | -14.64%-11.78% | -54.25%-23.45% | -70.43%-30.87% |
| Max drawdown duration | BBC XPH | 23d23d | 60d50d | 340d322d | 1666d1452d |
Trading data
BBC | XPH | |
Last sale 9/11/2026 at 1:30 PM | $49.39 | $67.51 |
| Previous close 09/10/2026 | $49.91 | $68.01 |
| Consolidated volume 09/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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BBC | XPH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 9/11/2026 at 1:30 PM
Live
Closed
BBC | XPH | |
|---|---|---|
| Last price | $49.39 | $67.51 |
| 1D performance | -1.05% | -0.74% |
| AuM | $46.95 M | $588.06 M |
| E/R | 0.65% | 0.35% |
Characteristics
BBC | XPH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | State Street Investment Management |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S&P Pharmaceuticals Select Industry Index |
| N° of holdings | 127 | 62 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
86.49%
Other
13.51%
XPH
USA
89.67%
Other
10.33%
Sectors
BBC
Healthcare
95.06%
Other
4.94%
XPH
Healthcare
92.7%
Other
7.3%
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Diversification
BBC
Total weight of top 15 holdings out of 15
15.32%
XPH
Total weight of top 15 holdings out of 15
32.65%
Top 15 holdings
Data as of July 31, 2026
BBC
First Tracks Biotherapeutics, Inc.
1.57%
Monopar Therapeutics, Inc.
1.22%
MBX Biosciences, Inc.
1.14%
Zenas BioPharma, Inc.
1.09%
Xencor, Inc.
1.06%
Apogee Therapeutics, Inc.
1.00%
REGENXBIO, Inc.
0.96%
Oric Pharmaceuticals, Inc.
0.96%
Dyne Therapeutics, Inc.
0.93%
uniQure NV
0.91%
SELLAS Life Sciences Group, Inc.
0.91%
Nurix Therapeutics, Inc.
0.91%
Vor Biopharma, Inc.
0.89%
Erasca, Inc.
0.89%
Amylyx Pharmaceuticals, Inc.
0.88%
XPH
Crinetics Pharmaceuticals, Inc.
3.69%
MBX Biosciences, Inc.
3.22%
Amylyx Pharmaceuticals, Inc.
2.29%
Enliven Therapeutics, Inc.
2.24%
Corcept Therapeutics, Inc.
2.22%
Alumis, Inc.
2.13%
Nuvation Bio, Inc.
2.09%
Trevi Therapeutics, Inc.
2.06%
Liquidia Corp.
1.95%
Nektar Therapeutics
1.89%
Amneal Pharmaceuticals, Inc.
1.81%
Bristol Myers Squibb Co.
1.78%
Edgewise Therapeutics, Inc.
1.77%
Omeros Corp.
1.76%
Ligand Pharmaceuticals, Inc.
1.75%
Frequently asked questions about BBC and XPH
How have the BBC and XPH ETFs performed in 2026?
As of September 11, 2026, BBC is up 27.77% year-to-date (YTD), while XPH has returned 20.76%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or XPH?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$296M for XPH.
Which ETF is more volatile: BBC or XPH?
Over the past year, BBC had a volatility of 36.22%, while XPH experienced 22.63%.
Which ETF is bigger: BBC or XPH?
As of September 11, 2026, BBC holds $46.95 M in assets under management (AUM), while XPH manages $588.06 M.
What sectors do the BBC and XPH ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, XPH focuses on Healthcare.
What are the top holdings of the BBC ETF and XPH ETF?
BBC top holdings include First Tracks Biotherapeutics, Inc., Monopar Therapeutics, Inc. and MBX Biosciences, Inc.. XPH holds in its top three: Crinetics Pharmaceuticals, Inc., MBX Biosciences, Inc. and Amylyx Pharmaceuticals, Inc..
Which ETF is more diversified: BBC or XPH?
BBC holds 127 securities with 15.32% of its assets in the top 15. XPH has 63 securities and a top 15 weight of 32.65%.
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