BBCvsXPHETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. State Street SPDR S&P Pharmaceuticals ETF (XPH) is part of the US Health Care segment. Both ETFs have the same top 1 sector exposures: Healthcare. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.35% for XPH. BBC is up 10.7% year-to-date (YTD) with +$5M in YTD flows. XPH performs better with 15.31% YTD performance, and +$189M in YTD flows. Run a side-by-side ETF comparison of BBC and XPH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs XPH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC XPH | -7.04%-3.46% | -13.67%-6.38% | +10.70%+15.31% | +36.99%+32.72% | +160.59%+87.71% | +1.02%+43.55% |
| Flows | BBC XPH | --$76M | -+$14M | +$5M+$189M | +$12M+$209M | +$16M+$163M | +$8M+$162M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC XPH | +36.77%+22.86% | +36.97%+23.37% | +37.66%+20.82% | +40.00%+21.09% |
| Max drawdown | BBC XPH | -29.70%-16.58% | -29.70%-16.58% | -54.25%-23.45% | -70.04%-30.87% |
| Max drawdown duration | BBC XPH | 69d70d | 69d70d | 340d322d | 1625d1452d |
Trading data
BBC | XPH | |
Last sale 10/28/2026 at 1:30 PM | $43.95 | $64.55 |
| Previous close 10/28/2026 | $42.87 | $63.96 |
| Consolidated volume 10/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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BBC | XPH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/28/2026 at 1:30 PM
Live
Closed
BBC | XPH | |
|---|---|---|
| Last price | $43.95 | $64.55 |
| 1D performance | +2.51% | +0.92% |
| AuM | $40.68 M | $454.72 M |
| E/R | 0.65% | 0.35% |
Characteristics
BBC | XPH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | State Street Investment Management |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S&P Pharmaceuticals Select Industry Index |
| N° of holdings | 127 | 62 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
87.24%
Other
12.76%
XPH
USA
89.77%
Other
10.23%
Sectors
BBC
Healthcare
96.27%
Other
3.73%
XPH
Healthcare
93.27%
Other
6.73%
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Diversification
BBC
Total weight of top 15 holdings out of 15
17.14%
XPH
Total weight of top 15 holdings out of 15
34.13%
Top 15 holdings
Data as of August 31, 2026
BBC
Amylyx Pharmaceuticals, Inc.
1.50%
First Tracks Biotherapeutics, Inc.
1.48%
AbCellera Biologics, Inc.
1.38%
Xencor, Inc.
1.36%
Monopar Therapeutics, Inc.
1.12%
MBX Biosciences, Inc.
1.11%
uniQure NV
1.09%
Replimune Group, Inc.
1.06%
4D Molecular Therapeutics, Inc.
1.04%
SELLAS Life Sciences Group, Inc.
1.04%
Alto Neuroscience, Inc.
1.00%
LB Pharmaceuticals, Inc.
1.00%
Oric Pharmaceuticals, Inc.
0.99%
Zenas BioPharma, Inc.
0.98%
Cullinan Therapeutics, Inc.
0.98%
XPH
Amylyx Pharmaceuticals, Inc.
3.65%
Crinetics Pharmaceuticals, Inc.
3.60%
MBX Biosciences, Inc.
2.89%
Omeros Corp.
2.68%
Enliven Therapeutics, Inc.
2.28%
Nuvation Bio, Inc.
2.12%
Corcept Therapeutics, Inc.
2.11%
Eton Pharmaceuticals, Inc.
2.08%
Perrigo Co. Plc
1.91%
Edgewise Therapeutics, Inc.
1.85%
Nektar Therapeutics
1.83%
Merck & Co., Inc.
1.81%
Trevi Therapeutics, Inc.
1.80%
Tarsus Pharmaceuticals, Inc.
1.76%
Bristol Myers Squibb Co.
1.75%
Frequently asked questions about BBC and XPH
How have the BBC and XPH ETFs performed in 2026?
As of October 27, 2026, BBC is up 10.7% year-to-date (YTD), while XPH has returned 15.31%. That puts XPH better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or XPH?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$189M for XPH.
Which ETF is more volatile: BBC or XPH?
Over the past year, BBC had a volatility of 36.97%, while XPH experienced 23.37%.
Which ETF is bigger: BBC or XPH?
As of October 27, 2026, BBC holds $40.68 M in assets under management (AUM), while XPH manages $454.72 M.
What sectors do the BBC and XPH ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, XPH focuses on Healthcare.
What are the top holdings of the BBC ETF and XPH ETF?
BBC top holdings include Amylyx Pharmaceuticals, Inc., First Tracks Biotherapeutics, Inc. and AbCellera Biologics, Inc.. XPH holds in its top three: Amylyx Pharmaceuticals, Inc., Crinetics Pharmaceuticals, Inc. and MBX Biosciences, Inc..
Which ETF is more diversified: BBC or XPH?
BBC holds 127 securities with 17.14% of its assets in the top 15. XPH has 62 securities and a top 15 weight of 34.13%.
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