BBCvsXPHETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. State Street SPDR S&P Pharmaceuticals ETF (XPH) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Healthcare. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.35% for XPH. BBC is up 28.23% year-to-date (YTD) with +$5M in YTD flows. XPH performs worse with 22.32% YTD performance, and +$175M in YTD flows. Run a side-by-side ETF comparison of BBC and XPH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs XPH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC XPH | -5.49%+3.23% | +8.79%+18.49% | +28.23%+22.32% | +126.14%+60.58% | +122.92%+68.59% | +14.49%+40.57% |
| Flows | BBC XPH | +$83K+$61M | +$5M+$60M | +$5M+$175M | +$11M+$200M | +$15M+$128M | +$6M+$141M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC XPH | +38.48%+24.47% | +35.85%+22.24% | +37.04%+20.33% | +39.65%+20.88% |
| Max drawdown | BBC XPH | -11.52%-8.13% | -14.64%-11.78% | -54.25%-23.45% | -70.93%-31.59% |
| Max drawdown duration | BBC XPH | 44d41d | 60d50d | 340d322d | 1754d1566d |
Trading data
BBC | XPH | |
Last sale 7/27/2026 at 7:57 PM | $49.74 | $68.40 |
| Previous close 07/27/2026 | $49.67 | $68.54 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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BBC | XPH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 7:57 PM
Live
Closed
BBC | XPH | |
|---|---|---|
| Last price | $49.74 | $68.40 |
| 1D performance | +0.14% | -0.20% |
| AuM | $47.12 M | $479.27 M |
| E/R | 0.65% | 0.35% |
Characteristics
BBC | XPH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | State Street Investment Management |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S&P Pharmaceuticals Select Industry Index |
| N° of holdings | 125 | 63 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
85.4%
Other
14.6%
XPH
USA
90.15%
Other
9.85%
Sectors
BBC
Healthcare
95.19%
Other
4.81%
XPH
Healthcare
94.73%
Other
5.27%
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Diversification
BBC
Total weight of top 15 holdings out of 15
14.01%
XPH
Total weight of top 15 holdings out of 15
29.74%
Top 15 holdings
Data as of June 30, 2026
BBC
uniQure NV
1.18%
REGENXBIO, Inc.
1.01%
Apogee Therapeutics, Inc.
0.99%
Monopar Therapeutics, Inc.
0.97%
Jade Biosciences, Inc.
0.94%
Aktis Oncology, Inc.
0.94%
MBX Biosciences, Inc.
0.94%
Biohaven Ltd.
0.90%
Kymera Therapeutics, Inc.
0.89%
Cullinan Therapeutics, Inc.
0.89%
SELLAS Life Sciences Group, Inc.
0.89%
Generate Biomedicines, Inc.
0.88%
Nurix Therapeutics, Inc.
0.87%
Intellia Therapeutics, Inc.
0.87%
4D Molecular Therapeutics, Inc.
0.86%
XPH
MBX Biosciences, Inc.
2.72%
Alumis, Inc.
2.14%
Trevi Therapeutics, Inc.
2.12%
Enliven Therapeutics, Inc.
2.09%
Amylyx Pharmaceuticals, Inc.
2.04%
Veradermics, Inc.
2.02%
Ligand Pharmaceuticals, Inc.
1.94%
Nuvation Bio, Inc.
1.89%
Edgewise Therapeutics, Inc.
1.88%
Nektar Therapeutics
1.88%
Liquidia Corp.
1.86%
Maze Therapeutics, Inc.
1.85%
Harrow, Inc.
1.81%
EyePoint, Inc.
1.77%
Amneal Pharmaceuticals, Inc.
1.72%
Frequently asked questions about BBC and XPH
How have the BBC and XPH ETFs performed in 2026?
As of July 27, 2026, BBC is up 28.23% year-to-date (YTD), while XPH has returned 22.32%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or XPH?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$175M for XPH.
Which ETF is more volatile: BBC or XPH?
Over the past year, BBC had a volatility of 35.85%, while XPH experienced 22.24%.
Which ETF is bigger: BBC or XPH?
As of July 27, 2026, BBC holds $47.12 M in assets under management (AUM), while XPH manages $479.27 M.
What sectors do the BBC and XPH ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, XPH focuses on Healthcare.
What are the top holdings of the BBC ETF and XPH ETF?
BBC top holdings include uniQure NV, REGENXBIO, Inc. and Apogee Therapeutics, Inc.. XPH holds in its top three: MBX Biosciences, Inc., Alumis, Inc. and Trevi Therapeutics, Inc..
Which ETF is more diversified: BBC or XPH?
BBC holds 125 securities with 14.01% of its assets in the top 15. XPH has 63 securities and a top 15 weight of 29.74%.
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