XPHvsPTHETF Comparison
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State Street SPDR S&P Pharmaceuticals ETF (XPH) and Invesco DWA Healthcare Momentum ETF (PTH) belong to the same industry segment: US Health Care. XPH's top 1 sector exposures are Healthcare. In contrast, PTH's top sector exposures are Healthcare and Consumer Non-Cyclicals. XPH is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.72% for PTH. XPH is up 12.48% year-to-date (YTD) with +$186M in YTD flows. PTH performs better with 18.53% YTD performance, and +$149M in YTD flows. Run a side-by-side ETF comparison of XPH and PTH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XPH vs PTH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/26/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH PTH | -5.82%-4.74% | -8.05%+1.09% | +12.48%+18.53% | +28.86%+28.12% | +80.65%+104.26% | +39.77%+13.41% |
| Flows | XPH PTH | -$80M+$7M | +$11M+$61M | +$186M+$149M | +$206M+$158M | +$160M+$102M | +$157M-$110M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH PTH | +22.75%+29.04% | +23.36%+26.84% | +20.82%+26.03% | +21.10%+25.90% |
| Max drawdown | XPH PTH | -16.58%-12.72% | -16.58%-12.72% | -23.45%-27.71% | -30.87%-47.24% |
| Max drawdown duration | XPH PTH | 68d68d | 68d68d | 322d353d | 1452d1688d |
Trading data
XPH | PTH | |
Last sale 10/27/2026 at 1:30 PM | $63.96 | $60.22 |
| Previous close 10/26/2026 | $62.90 | $58.96 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XPH | PTH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
XPH | PTH | |
|---|---|---|
| Last price | $63.96 | $60.22 |
| 1D performance | +1.69% | +2.14% |
| AuM | $440.44 M | $291.10 M |
| E/R | 0.35% | 0.72% |
Characteristics
XPH | PTH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Pharmaceuticals Select Industry Index | Dorsey Wright Healthcare Technical Leaders Index |
| N° of holdings | 62 | 54 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | October 12, 2006 |
| ESG | No | No |
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Exposure
Countries
XPH
USA
89.77%
Other
10.23%
PTH
USA
90%
Other
10%
Sectors
XPH
Healthcare
93.27%
Other
6.73%
PTH
Healthcare
99.31%
Other
0.69%
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Diversification
XPH
Total weight of top 15 holdings out of 15
34.13%
PTH
Total weight of top 15 holdings out of 15
49.11%
Top 15 holdings
Data as of August 31, 2026
XPH
Amylyx Pharmaceuticals, Inc.
3.65%
Crinetics Pharmaceuticals, Inc.
3.60%
MBX Biosciences, Inc.
2.89%
Omeros Corp.
2.68%
Enliven Therapeutics, Inc.
2.28%
Nuvation Bio, Inc.
2.12%
Corcept Therapeutics, Inc.
2.11%
Eton Pharmaceuticals, Inc.
2.08%
Perrigo Co. Plc
1.91%
Edgewise Therapeutics, Inc.
1.85%
Nektar Therapeutics
1.83%
Merck & Co., Inc.
1.81%
Trevi Therapeutics, Inc.
1.80%
Tarsus Pharmaceuticals, Inc.
1.76%
Bristol Myers Squibb Co.
1.75%
PTH
Revolution Medicines, Inc.
5.32%
Roivant Sciences Ltd.
5.01%
Guardant Health, Inc.
4.73%
Moderna, Inc.
4.51%
BrightSpring Health Services, Inc.
3.76%
Axsome Therapeutics, Inc.
3.57%
Erasca, Inc.
2.89%
10X Genomics, Inc.
2.85%
Oruka Therapeutics, Inc.
2.50%
Replimune Group, Inc.
2.46%
Twist Bioscience Corp.
2.43%
Travere Therapeutics, Inc.
2.38%
Axogen, Inc.
2.31%
Liquidia Corp.
2.29%
Relay Therapeutics, Inc.
2.12%
Frequently asked questions about XPH and PTH
How have the XPH and PTH ETFs performed in 2026?
As of October 26, 2026, XPH is up 12.48% year-to-date (YTD), while PTH has returned 18.53%. That puts PTH better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or PTH?
Year-to-date, the XPH ETF saw +$186M in flows, compared to +$149M for PTH.
Which ETF is more volatile: XPH or PTH?
Over the past year, XPH had a volatility of 23.36%, while PTH experienced 26.84%.
Which ETF is bigger: XPH or PTH?
As of October 26, 2026, XPH holds $440.44 M in assets under management (AUM), while PTH manages $291.10 M.
What sectors do the XPH and PTH ETFs invest in?
XPH leans toward sectors like Healthcare. Meanwhile, PTH focuses on Healthcare.
What are the top holdings of the XPH ETF and PTH ETF?
XPH top holdings include Amylyx Pharmaceuticals, Inc., Crinetics Pharmaceuticals, Inc. and MBX Biosciences, Inc.. PTH holds in its top three: Revolution Medicines, Inc., Roivant Sciences Ltd. and Guardant Health, Inc..
Which ETF is more diversified: XPH or PTH?
XPH holds 62 securities with 34.13% of its assets in the top 15. PTH has 54 securities and a top 15 weight of 49.11%.
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Latest news about XPH & PTH
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XPH
Analyzing the Potential ETF Winners & Losers from The Weight-Loss Drug Craze
November 20, 2023
XPH
Continued tightening of the U.S. labor market
September 23, 2022
PTH
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