XPHvsPBEETF Comparison
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State Street SPDR S&P Pharmaceuticals ETF (XPH) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XPH is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.58% for PBE. XPH is up 2.61% year-to-date (YTD) with +$116M in YTD flows. PBE performs worse with -2.66% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of XPH and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XPH vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH PBE | +9.68%+4.27% | +2.44%-3.98% | +2.61%-2.66% | +44.99%+32.11% | +40.83%+28.24% | +22.16%+3.38% |
| Flows | XPH PBE | +$25M+$2M | +$82M-$6M | +$116M-$2M | +$141M-$30M | +$48M-$58M | +$64M-$43M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH PBE | +24.78%+19.57% | +21.12%+19.83% | +19.49%+20.15% | +20.45%+22.54% |
| Max drawdown | XPH PBE | -11.78%-9.36% | -11.78%-11.70% | -23.45%-22.21% | -31.59%-34.74% |
| Max drawdown duration | XPH PBE | 50d75d | 50d107d | 322d324d | 1566d1540d |
Trading data
XPH | PBE | |
Last sale 4/27/2026 at 1:30 PM | $57.90 | $79.93 |
| Previous close 04/24/2026 | $57.40 | $79.82 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XPH | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/27/2026 at 1:30 PM
Live
Closed
XPH | PBE | |
|---|---|---|
| Last price | $57.90 | $79.93 |
| 1D performance | +0.87% | +0.14% |
| AuM | $353.54 M | $249.88 M |
| E/R | 0.35% | 0.58% |
Characteristics
XPH | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Pharmaceuticals Select Industry Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 48 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
XPH
USA
87.77%
Other
12.23%
PBE
USA
92.18%
Other
7.82%
Sectors
XPH
Health Care
82.36%
Other
17.64%
PBE
Health Care
97.59%
Other
2.41%
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Diversification
XPH
Total weight of top 15 holdings out of 15
30.65%
PBE
Total weight of top 15 holdings out of 15
63.66%
Top 15 holdings
Data as of March 31, 2026
XPH
US29337E1029
2.45%
CORCEPT THERAPEUTICS
2.29%
TERNS PHARMACEUTICALS
2.16%
PERRIGO CO PLC
2.10%
AXSOME THERA CMN STK
2.03%
INNOVIVA INC
1.99%
MERCK & CO INC
1.98%
PFIZER
1.97%
ROYALTY PHARMA
1.97%
ELANCO ANIMAL HEALTH INC
1.96%
JAZZ PHARMACEUTICALS
1.96%
ESPERION THERAPEUTICS
1.95%
EDGEWISE THERAPEUTICS
1.95%
US55287L1017
1.95%
BRISTOL-MYERS SQUIBB
1.94%
PBE
UTD THERAPEUT
6.05%
ILLUMINA
5.24%
REGENERON PHARMACEUTICALS
5.23%
ALNYLAM PHARMACEUTICALS
5.22%
BIOGEN INC
5.16%
AMGEN-T
4.99%
GILEAD SCIENCES
4.98%
INCYTE
4.89%
BIOCRYST PHARMACEUTICALS
3.66%
PROTAGONIST THERAPEUTICS INC
3.38%
TG THERAPEUTICS
3.11%
ROYALTY PHARMA
3.05%
NEUROCRINE BIOSCIENCES
2.93%
CATALYST PHARMACEUTICALS INC
2.89%
PTC THERAPEUTI/D
2.86%
Frequently asked questions about XPH and PBE
How have the XPH and PBE ETFs performed in 2026?
As of April 24, 2026, XPH is up 2.61% year-to-date (YTD), while PBE has lost -2.66%. That puts XPH better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or PBE?
Year-to-date, the XPH ETF saw +$116M in flows, compared to -$2M for PBE.
Which ETF is more volatile: XPH or PBE?
Over the past year, XPH had a volatility of 21.12%, while PBE experienced 19.83%.
Which ETF is bigger: XPH or PBE?
As of April 24, 2026, XPH holds $353.54 M in assets under management (AUM), while PBE manages $249.88 M.
What sectors do the XPH and PBE ETFs invest in?
XPH leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.
What are the top holdings of the XPH ETF and PBE ETF?
XPH top holdings include US29337E1029, CORCEPT THERAPEUTICS and TERNS PHARMACEUTICALS. PBE holds in its top three: UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS.
Which ETF is more diversified: XPH or PBE?
XPH holds 57 securities with 30.65% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.66%.
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