XPHvsLFSCETF Comparison
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State Street SPDR S&P Pharmaceuticals ETF (XPH) belongs to the US Health Care segment. F/m Emerald Life Sciences Innovation ETF (LFSC) is part of the Life Sciences segment. Both ETFs have the same top 3 sector exposures: and Health Care. XPH is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.79% for LFSC. XPH is up 2.61% year-to-date (YTD) with +$116M in YTD flows. LFSC performs worse with 2.35% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of XPH and LFSC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XPH vs LFSC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH LFSC | +9.68%+12.76% | +2.44%+3.57% | +2.61%+2.35% | +44.99%+67.06% | +40.83%n/a | +22.16%n/a |
| Flows | XPH LFSC | +$25M-$211K | +$82M+$6M | +$116M+$5M | +$141M+$15M | +$48M- | +$64M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH LFSC | +24.78%+28.73% | +21.12%+26.18% | +19.49%n/a | +20.45%n/a |
| Max drawdown | XPH LFSC | -11.78%-10.65% | -11.78%-16.25% | -23.45%n/a | -31.59%n/a |
| Max drawdown duration | XPH LFSC | 50d47d | 50d135d | 322dn/a | 1566dn/a |
Trading data
XPH | LFSC | |
Last sale 4/24/2026 at 1:30 PM | $57.40 | $37.49 |
| Previous close 04/24/2026 | $57.20 | $37.27 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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LFSC
is actively managed and doesn’t replicate an indexXPH | LFSC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/24/2026 at 1:30 PM
Live
Closed
XPH | LFSC | |
|---|---|---|
| Last price | $57.40 | $37.49 |
| 1D performance | +0.35% | +0.60% |
| AuM | $353.54 M | $99.94 M |
| E/R | 0.35% | 0.79% |
Characteristics
XPH | LFSC | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | State Street Investment Management | Emerald Group |
| Benchmark | S&P Pharmaceuticals Select Industry Index | - |
| N° of holdings | 48 | 33 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | October 31, 2024 |
| ESG | No | No |
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Exposure
Countries
XPH
USA
87.77%
Other
12.23%
LFSC
USA
90.82%
United Kingdom
7.06%
Other
2.12%
Sectors
XPH
Health Care
82.36%
Other
17.64%
LFSC
Health Care
78.16%
Other
21.84%
Diversification
XPH
Total weight of top 15 holdings out of 15
30.65%
LFSC
Total weight of top 15 holdings out of 15
69.28%
Top 15 holdings
Data as of March 31, 2026
XPH
US29337E1029
2.45%
CORCEPT THERAPEUTICS
2.29%
TERNS PHARMACEUTICALS
2.16%
PERRIGO CO PLC
2.10%
AXSOME THERA CMN STK
2.03%
INNOVIVA INC
1.99%
MERCK & CO INC
1.98%
PFIZER
1.97%
ROYALTY PHARMA
1.97%
ELANCO ANIMAL HEALTH INC
1.96%
JAZZ PHARMACEUTICALS
1.96%
ESPERION THERAPEUTICS
1.95%
EDGEWISE THERAPEUTICS
1.95%
US55287L1017
1.95%
BRISTOL-MYERS SQUIBB
1.94%
LFSC
COGENT BIOSCIENCES
9.11%
LIVANOVA
7.06%
UTD THERAPEUT
5.61%
US00773J2024
5.14%
MIRUM PHARMACEUTICALS INC
5.09%
TRAVERE THERAPEUTICS INC
4.75%
KALVISTA PHARMACEUTICALS INC
4.74%
GUARDANT HEALTH INC
4.38%
BRIDGEBIO PHARMA
4.05%
US6402683063
3.78%
TRANSMEDICS GROUP
3.77%
SAVARA INC
3.74%
TREVI THERAPEUTICS
2.95%
ICU MEDICAL
2.79%
AXSOME THERA CMN STK
2.32%
Frequently asked questions about XPH and LFSC
How have the XPH and LFSC ETFs performed in 2026?
As of April 24, 2026, XPH is up 2.61% year-to-date (YTD), while LFSC has returned 2.35%. That puts XPH better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or LFSC?
Year-to-date, the XPH ETF saw +$116M in flows, compared to +$5M for LFSC.
Which ETF is more volatile: XPH or LFSC?
Over the past year, XPH had a volatility of 21.12%, while LFSC experienced 26.18%.
Which ETF is bigger: XPH or LFSC?
As of April 24, 2026, XPH holds $353.54 M in assets under management (AUM), while LFSC manages $99.94 M.
What sectors do the XPH and LFSC ETFs invest in?
XPH leans toward sectors like Health Care. Meanwhile, LFSC focuses on Health Care.
What are the top holdings of the XPH ETF and LFSC ETF?
XPH top holdings include US29337E1029, CORCEPT THERAPEUTICS and TERNS PHARMACEUTICALS. LFSC holds in its top three: COGENT BIOSCIENCES, LIVANOVA and UTD THERAPEUT.
Which ETF is more diversified: XPH or LFSC?
XPH holds 57 securities with 30.65% of its assets in the top 15. LFSC has 44 securities and a top 15 weight of 69.28%.
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