XPHvsLFSCETF Comparison
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State Street SPDR S&P Pharmaceuticals ETF (XPH) belongs to the US Health Care segment. F/m Emerald Life Sciences Innovation ETF (LFSC) is part of the Life Sciences segment. Both ETFs have the same top 3 sector exposures: and Health Care. XPH is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.79% for LFSC. XPH is up 7.68% year-to-date (YTD) with +$110M in YTD flows. LFSC performs better with 9.73% YTD performance, and +$6M in YTD flows. Run a side-by-side ETF comparison of XPH and LFSC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XPH vs LFSC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/12/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH LFSC | +3.73%+4.67% | +12.67%+18.71% | +7.68%+9.73% | +44.62%+62.86% | +53.31%n/a | +21.61%n/a |
| Flows | XPH LFSC | -$8M+$1M | +$23M+$1M | +$110M+$6M | +$133M+$16M | +$51M- | +$63M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH LFSC | +25.05%+29.69% | +21.48%+26.57% | +19.89%n/a | +20.72%n/a |
| Max drawdown | XPH LFSC | -8.13%-6.53% | -11.78%-16.25% | -23.45%n/a | -31.59%n/a |
| Max drawdown duration | XPH LFSC | 37d20d | 50d168d | 322dn/a | 1566dn/a |
Trading data
XPH | LFSC | |
Last sale 6/12/2026 at 1:30 PM | $60.27 | $40.17 |
| Previous close 06/11/2026 | $59.77 | $39.72 |
| Consolidated volume 06/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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LFSC
is actively managed and doesn’t replicate an indexXPH | LFSC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/12/2026 at 1:30 PM
Live
Closed
XPH | LFSC | |
|---|---|---|
| Last price | $60.27 | $40.17 |
| 1D performance | +0.84% | +1.12% |
| AuM | $364.98 M | $108.34 M |
| E/R | 0.35% | 0.79% |
Characteristics
XPH | LFSC | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | State Street Investment Management | Emerald Group |
| Benchmark | S&P Pharmaceuticals Select Industry Index | - |
| N° of holdings | 48 | 33 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | October 31, 2024 |
| ESG | No | No |
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Exposure
Countries
XPH
USA
89.49%
Other
10.51%
LFSC
USA
91.24%
Other
8.76%
Sectors
XPH
Health Care
82.05%
Other
17.95%
LFSC
Health Care
73.79%
Other
26.21%
Diversification
XPH
Total weight of top 15 holdings out of 15
33.31%
LFSC
Total weight of top 15 holdings out of 15
69.25%
Top 15 holdings
Data as of April 30, 2026
XPH
ORGANON & CO
3.72%
CORCEPT THERAPEUTICS
2.48%
US29337E1029
2.41%
AXSOME THERA CMN STK
2.34%
OMEROS
2.20%
PERRIGO CO PLC
2.17%
US6402683063
2.08%
TREVI THERAPEUTICS
2.07%
TERNS PHARMACEUTICALS
2.03%
US45579U1097
2.01%
PACIRA BIOSCIENCES INC
2.00%
HARROW HEALTH
1.97%
JAZZ PHARMACEUTICALS
1.97%
HARMONY BIOSCIENCES HLDG
1.95%
ROYALTY PHARMA
1.93%
LFSC
COGENT BIOSCIENCES
8.24%
TRAVERE THERAPEUTICS INC
6.94%
US00773J2024
6.56%
LIVANOVA
6.39%
MIRUM PHARMACEUTICALS INC
4.69%
UTD THERAPEUT
4.43%
US6402683063
4.39%
KALVISTA PHARMACEUTICALS INC
4.33%
GUARDANT HEALTH INC
3.94%
BRIDGEBIO PHARMA
3.81%
TRANSMEDICS GROUP
3.78%
SAVARA INC
3.34%
TREVI THERAPEUTICS
3.29%
US9229671048
2.75%
AXSOME THERA CMN STK
2.37%
Frequently asked questions about XPH and LFSC
How have the XPH and LFSC ETFs performed in 2026?
As of June 12, 2026, XPH is up 7.68% year-to-date (YTD), while LFSC has returned 9.73%. That puts LFSC better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or LFSC?
Year-to-date, the XPH ETF saw +$110M in flows, compared to +$6M for LFSC.
Which ETF is more volatile: XPH or LFSC?
Over the past year, XPH had a volatility of 21.48%, while LFSC experienced 26.57%.
Which ETF is bigger: XPH or LFSC?
As of June 12, 2026, XPH holds $364.98 M in assets under management (AUM), while LFSC manages $108.34 M.
What sectors do the XPH and LFSC ETFs invest in?
XPH leans toward sectors like Health Care. Meanwhile, LFSC focuses on Health Care.
What are the top holdings of the XPH ETF and LFSC ETF?
XPH top holdings include ORGANON & CO, CORCEPT THERAPEUTICS and US29337E1029. LFSC holds in its top three: COGENT BIOSCIENCES, TRAVERE THERAPEUTICS INC and US00773J2024.
Which ETF is more diversified: XPH or LFSC?
XPH holds 58 securities with 33.31% of its assets in the top 15. LFSC has 46 securities and a top 15 weight of 69.25%.
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