XPHvsGNOMETF Comparison
VS
State Street SPDR S&P Pharmaceuticals ETF (XPH) belongs to the US Health Care segment. Global X Genomics & Biotechnology ETF - USD (GNOM) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XPH is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for GNOM. XPH is up 2.61% year-to-date (YTD) with +$116M in YTD flows. GNOM performs worse with 0.74% YTD performance, and -$602K in YTD flows. Run a side-by-side ETF comparison of XPH and GNOM below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
Find out how industry players manage ETF portfolios. Discover our library of Model portfolios
XPH vs GNOM performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH GNOM | +9.68%+7.67% | +2.44%-7.03% | +2.61%+0.74% | +44.99%+41.51% | +40.83%-6.56% | +22.16%-50.60% |
| Flows | XPH GNOM | +$25M-$829K | +$82M+$1M | +$116M-$602K | +$141M-$14M | +$48M-$120M | +$64M+$1M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH GNOM | +24.78%+28.47% | +21.12%+27.16% | +19.49%+28.79% | +20.45%+33.22% |
| Max drawdown | XPH GNOM | -11.78%-16.08% | -11.78%-18.16% | -23.45%-46.50% | -31.59%-72.17% |
| Max drawdown duration | XPH GNOM | 50d88d | 50d92d | 322d1075d | 1566d1758d |
Trading data
XPH | GNOM | |
Last sale 4/27/2026 at 1:49 PM | $58.81 | $45.97 |
| Previous close 04/24/2026 | $57.40 | $46.16 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
Create an account to view replication metrics
Join for free
XPH | GNOM | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
Advertisement
Main metrics
Last update 4/27/2026 at 1:49 PM
Live
Closed
XPH | GNOM | |
|---|---|---|
| Last price | $58.81 | $45.97 |
| 1D performance | +2.46% | -0.42% |
| AuM | $353.54 M | $51.60 M |
| E/R | 0.35% | 0.5% |
Characteristics
XPH | GNOM | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Global X |
| Benchmark | S&P Pharmaceuticals Select Industry Index | Solactive Genomics Index |
| N° of holdings | 48 | 45 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | April 5, 2019 |
| ESG | No | No |
Advertisement
Exposure
Countries
XPH
USA
87.77%
Other
12.23%
GNOM
USA
87.57%
Other
12.43%
Sectors
XPH
Health Care
82.36%
Other
17.64%
GNOM
Health Care
88.49%
Other
11.51%
Advertisement
Diversification
XPH
Total weight of top 15 holdings out of 15
30.65%
GNOM
Total weight of top 15 holdings out of 15
66.21%
Top 15 holdings
Data as of March 31, 2026
XPH
US29337E1029
2.45%
CORCEPT THERAPEUTICS
2.29%
TERNS PHARMACEUTICALS
2.16%
PERRIGO CO PLC
2.10%
AXSOME THERA CMN STK
2.03%
INNOVIVA INC
1.99%
MERCK & CO INC
1.98%
PFIZER
1.97%
ROYALTY PHARMA
1.97%
ELANCO ANIMAL HEALTH INC
1.96%
JAZZ PHARMACEUTICALS
1.96%
ESPERION THERAPEUTICS
1.95%
EDGEWISE THERAPEUTICS
1.95%
US55287L1017
1.95%
BRISTOL-MYERS SQUIBB
1.94%
GNOM
MODERNA INC
8.48%
ARROWHEAD PHARMACEUTICALS INC
6.21%
US74006W2070
6.13%
ILLUMINA
5.52%
GUARDANT HEALTH INC
5.18%
VERTEX PHARMACEUTICALS
4.61%
BIOMARIN PHARMACEUTICAL
4.59%
NATERA
4.21%
BIO-TECHNE CORP
3.64%
BIONTECH SE ADR
3.58%
CRISPR THERAPEUTICS
3.08%
BRISTOL-MYERS SQUIBB
3.05%
ALNYLAM PHARMACEUTICALS
2.85%
TWIST BIOSCIENCE CORP
2.54%
ASTRAZENECA
2.53%
Frequently asked questions about XPH and GNOM
How have the XPH and GNOM ETFs performed in 2026?
As of April 24, 2026, XPH is up 2.61% year-to-date (YTD), while GNOM has returned 0.74%. That puts XPH better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or GNOM?
Year-to-date, the XPH ETF saw +$116M in flows, compared to -$602K for GNOM.
Which ETF is more volatile: XPH or GNOM?
Over the past year, XPH had a volatility of 21.12%, while GNOM experienced 27.16%.
Which ETF is bigger: XPH or GNOM?
As of April 24, 2026, XPH holds $353.54 M in assets under management (AUM), while GNOM manages $51.60 M.
What sectors do the XPH and GNOM ETFs invest in?
XPH leans toward sectors like Health Care. Meanwhile, GNOM focuses on Health Care.
What are the top holdings of the XPH ETF and GNOM ETF?
XPH top holdings include US29337E1029, CORCEPT THERAPEUTICS and TERNS PHARMACEUTICALS. GNOM holds in its top three: MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070.
Which ETF is more diversified: XPH or GNOM?
XPH holds 57 securities with 30.65% of its assets in the top 15. GNOM has 47 securities and a top 15 weight of 66.21%.
Advertisement
Latest news about XPH & GNOM
Donald Trump’s Executive Orders: ETF Bulls and Bears
January 24, 2025
XPH
Analyzing the Potential ETF Winners & Losers from The Weight-Loss Drug Craze
November 20, 2023
XPH
Advertisement
Advertisement
