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XPHvsGNOMETF Comparison
SPDR S&P Pharmaceuticals ETF (XPH) belongs to the US Health Care segment. Global X Genomics & Biotechnology ETF - USD (GNOM) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XPH is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for GNOM. XPH is down -1.12% year-to-date (YTD) with +$88M in YTD flows. GNOM performs better with -0.99% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of XPH and GNOM below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
XPH vs GNOM performance and flow charts
Performance
Cumulative Flows
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH GNOM | -3.45%-2.35% | -1.36%-3.29% | -1.12%-0.99% | +29.22%+29.80% | +42.98%-6.02% | +9.16%-51.80% |
| Flows | XPH GNOM | +$12M- | +$95M-$4M | +$88M-$2M | +$111M-$19M | +$48M-$115M | +$36M+$11M |
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH GNOM | +20.33%+23.45% | +23.08%+30.08% | +19.01%+28.53% | +20.26%+33.47% |
| Max drawdown | XPH GNOM | -5.97%-10.89% | -17.10%-22.14% | -23.45%-46.50% | -33.10%-72.17% |
| Max drawdown duration | XPH GNOM | 14d48d | 140d113d | 322d1031d | 1706d1714d |
XPH | GNOM | |
Last sale 3/12/2026 at 1:30 PM | $53.64 | $43.93 |
| Previous close 03/11/2026 | $55.49 | $45.00 |
| Consolidated volume 03/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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XPH | GNOM | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
XPH | GNOM | |
|---|---|---|
| Last price | $53.64 | $43.93 |
| 1D performance | -3.33% | -2.38% |
| AuM | $313.37 M | $49.36 M |
| E/R | 0.35% | 0.5% |
Countries
Sectors
Diversification
Total weight of top 15 holdings out of 15
Total weight of top 15 holdings out of 15
Top 15 holdings
How have the XPH and GNOM ETFs performed in 2026?
As of March 11, 2026, XPH is down -1.12% year-to-date (YTD), while GNOM has lost -0.99%. That puts GNOM better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or GNOM?
Year-to-date, the XPH ETF saw +$88M in flows, compared to -$2M for GNOM.
Which ETF is more volatile: XPH or GNOM?
Over the past year, XPH had a volatility of 23.08%, while GNOM experienced 30.08%.
Which ETF is bigger: XPH or GNOM?
As of March 11, 2026, XPH holds $313.37 M in assets under management (AUM), while GNOM manages $49.36 M.
What sectors do the XPH and GNOM ETFs invest in?
XPH leans toward sectors like Health Care. Meanwhile, GNOM focuses on Health Care.
What are the top holdings of the XPH ETF and GNOM ETF?
XPH top holdings include LIQUIDIA CORPORATION, US55287L1017 and AXSOME THERA CMN STK. GNOM holds in its top three: MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070.
Which ETF is more diversified: XPH or GNOM?
XPH holds 57 securities with 32.4% of its assets in the top 15. GNOM has 48 securities and a top 15 weight of 63.95%.
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