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XLVIvsIXJETF Comparison

ETF 1
XLVI

The Health Care Select Sector SPDR Premium Income Fund

This fund is part of
Options Strategies
-1.02%
Full XLVI fund page
VS
ETF 2
IXJ

iShares Global Healthcare ETF

This fund is part of
Global Large Cap
-1.52%
Full IXJ fund page

The Health Care Select Sector SPDR Premium Income Fund (XLVI) belongs to the Options Strategies segment. iShares Global Healthcare ETF (IXJ) is part of the Global Large Cap segment. Both ETFs have the same top 3 sector exposures: and Health Care. XLVI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.4% for IXJ. XLVI is down -1.41% year-to-date (YTD) with +$2M in YTD flows. IXJ performs worse with -2.64% YTD performance, and -$688M in YTD flows. Run a side-by-side ETF comparison of XLVI and IXJ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XLVI vs IXJ performance and flow charts

Performance

-6.0-4.0-2.00.02.0%Feb 12Feb 20Feb 27Mar 6

Cumulative Flows

-600 M-500 M-400 M-300 M-200 M-100 M0 MFeb 12Feb 20Feb 27Mar 6

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 03/12/2026
1M3MYTD1Y3Y5Y
Perf.
XLVI
IXJ
-2.60%-5.34%
-0.20%-1.68%
-1.41%-2.64%
n/a+5.89%
n/a+24.23%
n/a+34.09%
Flows
XLVI
IXJ
+$788K-$599M
+$3M-$664M
+$2M-$688M
--$427M
--$883M
-+$219M
Volatility and drawdown
3M1Y3Y5Y
Volatility
XLVI
IXJ
+10.72%+13.35%
n/a+16.82%
n/a+13.09%
n/a+13.81%
Max drawdown
XLVI
IXJ
-4.68%-6.98%
n/a-10.89%
n/a-18.04%
n/a-18.04%
Max drawdown duration
XLVI
IXJ
11d11d
n/a196d
n/a490d
n/a490d
Trading data

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XLVI
IXJ
Last sale
3/13/2026 at 1:30 PM
$25.46
$94.30
Previous close
03/12/2026
$25.54
$94.78
Consolidated volume
03/12/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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XLVI
is actively managed and doesn’t replicate an index

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XLVI
IXJ
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/13/2026 at 1:30 PM
Live
Closed
XLVI
IXJ
Last price
$25.46
$94.30
1D performance
-0.32%
-0.51%
AuM$13.01 M$3.73 B
E/R0.35%0.4%
Characteristics
XLVI
IXJ
Management strategyActivePassive
ProviderSPDRiShares
Benchmark-S&P Global 1200 Healthcare Index
N° of holdings57105
Asset class-Equities
Trailing 12m distribution yield
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Inception dateJuly 30, 2025November 13, 2001
ESGNoNo
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Exposure

Countries

XLVI
USA
96.37%
Other
3.63%
IXJ
USA
67.85%
Switzerland
10.23%
Other
21.92%

Sectors

XLVI
Health Care
97.65%
Other
2.35%
IXJ
Health Care
93.2%
Other
6.8%
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Diversification

XLVI

Total weight of top 15 holdings out of 15

69.69%
IXJ

Total weight of top 15 holdings out of 15

55.7%

Top 15 holdings

Data as of January 31, 2026
XLVI
LILLY
14.60%
JOHNSON&JOHNSON
9.71%
ABBVIE
6.99%
MERCK & CO INC
4.85%
UNITEDHEALTH GRP
4.61%
THERMO FISHER SCIENTIFIC
3.85%
ABBOTT LABS
3.37%
AMGEN-T
3.26%
INTUITIVE SURGICAL
3.17%
GILEAD SCIENCES
3.12%
PFIZER
2.66%
BOSTON SCIENTIFIC
2.46%
DANAHER
2.44%
MEDTRONIC PLC
2.34%
STRYKER
2.25%
IXJ
LILLY
10.17%
JOHNSON&JOHNSON
6.85%
ABBVIE
4.87%
ROCHE
3.97%
ASTRAZENECA
3.59%
NOVARTIS
3.54%
MERCK & CO INC
3.36%
UNITEDHEALTH GRP
3.31%
THERMO FISHER SCIENTIFIC
2.79%
DK0062498333
2.36%
AMGEN-T
2.31%
ABBOTT LABS
2.30%
INTUITIVE SURGICAL
2.25%
GILEAD SCIENCES
2.16%
PFIZER
1.86%
Frequently asked questions about XLVI and IXJ

How have the XLVI and IXJ ETFs performed in 2026?

As of March 12, 2026, XLVI is down -1.41% year-to-date (YTD), while IXJ has lost -2.64%. That puts XLVI better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or IXJ?

Year-to-date, the XLVI ETF saw +$2M in flows, compared to -$688M for IXJ.

Which ETF is bigger: XLVI or IXJ?

As of March 12, 2026, XLVI holds $13.01 M in assets under management (AUM), while IXJ manages $3.73 B.

What sectors do the XLVI and IXJ ETFs invest in?

XLVI leans toward sectors like Health Care. Meanwhile, IXJ focuses on Health Care.

What are the top holdings of the XLVI ETF and IXJ ETF?

XLVI top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. IXJ holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.

Which ETF is more diversified: XLVI or IXJ?

XLVI holds 60 securities with 69.69% of its assets in the top 15. IXJ has 115 securities and a top 15 weight of 55.7%.

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