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XLVIvsIXJETF Comparison

ETF 1

XLVI

State Street Health Care Select Sector SPDR Premium Income Fund

This fund is part of

Options Strategies

-0.49%

Full XLVI fund page

VS

ETF 2

IXJ

iShares Global Healthcare ETF

This fund is part of

Global Large Cap

-0.85%

Full IXJ fund page

State Street Health Care Select Sector SPDR Premium Income Fund (XLVI) belongs to the Options Strategies segment. iShares Global Healthcare ETF (IXJ) is part of the Global Large Cap segment. XLVI's top 2 sector exposures are Healthcare and Consumer Non-Cyclicals. In contrast, IXJ's top sector exposures are Healthcare, Consumer Non-Cyclicals and Consumer Cyclicals. XLVI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.38% for IXJ. XLVI is up 5.69% year-to-date (YTD) with +$14M in YTD flows. IXJ performs worse with 4.53% YTD performance, and -$505M in YTD flows. Run a side-by-side ETF comparison of XLVI and IXJ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XLVI vs IXJ performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 09/10/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	XLVI IXJ	-3.75%-2.73%	+3.97%+6.84%	+5.69%+4.53%	+16.54%+16.47%	n/a+23.97%	n/a+24.37%
Flows	XLVI IXJ	+$4M-	+$11M+$233M	+$14M-$505M	+$25M-$256M	--$567M	-+$32M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	XLVI IXJ	+11.87%+18.48%	+11.09%+15.84%	n/a+14.22%	n/a+14.55%
Max drawdown	XLVI IXJ	-4.77%-6.17%	-8.21%-10.83%	n/a-18.04%	n/a-18.04%
Max drawdown duration	XLVI IXJ	16d16d	115d122d	n/a490d	n/a490d

Trading data

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	XLVI	IXJ
Last sale 9/11/2026 at 1:30 PM	$25.71	$100.76
Previous close 09/10/2026	$25.73	$100.89
Consolidated volume 09/10/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of August 31, 2026

1-year trailing difference

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XLVI

is actively managed and doesn’t replicate an index

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	XLVI	IXJ
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/11/2026 at 1:30 PM

Live

Closed

	XLVI	IXJ
Last price	$25.71	$100.76
1D performance	-0.07%	-0.13%
AuM	$25.47 M	$4.14 B
E/R	0.35%	0.38%

Characteristics

	XLVI	IXJ
Management strategy	Active	Passive
Provider	State Street Investment Management	iShares
Benchmark	-	S&P Global 1200 Health Care (Sector) Capped Index
N° of holdings	59	110
Asset class	-	-
Trailing 12m distribution yield	Join	Join
Inception date	July 30, 2025	November 13, 2001
ESG	No	No

More XLVI data on Trackinsight

More IXJ data on Trackinsight

Exposure

Countries

XLVI

USA

97.34%

Other

2.66%

IXJ

USA

69.7%

Switzerland

10.39%

Other

19.91%

Sectors

XLVI

Healthcare

97.32%

Other

2.68%

IXJ

Healthcare

97.09%

Other

2.91%

Diversification

XLVI

Total weight of top 15 holdings out of 15

71.63%

IXJ

Total weight of top 15 holdings out of 15

56.91%

Top 15 holdings

Data as of July 31, 2026

XLVI

Eli Lilly & Co.

15.45%

Johnson & Johnson

10.49%

AbbVie, Inc.

7.54%

UnitedHealth Group, Inc.

6.40%

Merck & Co., Inc.

5.47%

Thermo Fisher Scientific, Inc.

3.63%

Amgen, Inc.

3.53%

Abbott Laboratories

3.13%

Gilead Sciences, Inc.

2.75%

Pfizer Inc.

2.42%

Bristol Myers Squibb Co.

2.27%

CVS Health Corp.

2.27%

Intuitive Surgical, Inc.

2.13%

Danaher Corp.

2.09%

Vertex Pharmaceuticals, Inc.

2.06%

IXJ

Eli Lilly & Co.

10.27%

Johnson & Johnson

6.92%

AbbVie, Inc.

5.11%

UnitedHealth Group, Inc.

4.35%

Merck & Co., Inc.

4.06%

Roche Holding AG

3.89%

Novartis AG

3.64%

AstraZeneca PLC

3.35%

Thermo Fisher Scientific, Inc.

2.71%

Amgen, Inc.

2.65%

Abbott Laboratories

2.33%

Gilead Sciences, Inc.

2.06%

Novo Nordisk A/S

2.05%

Pfizer Inc.

1.80%

CVS Health Corp.

1.70%

Frequently asked questions about XLVI and IXJ

How have the XLVI and IXJ ETFs performed in 2026?

As of September 10, 2026, XLVI is up 5.69% year-to-date (YTD), while IXJ has returned 4.53%. That puts XLVI better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or IXJ?

Year-to-date, the XLVI ETF saw +$14M in flows, compared to -$505M for IXJ.

Which ETF is more volatile: XLVI or IXJ?

Over the past year, XLVI had a volatility of 11.09%, while IXJ experienced 15.84%.

Which ETF is bigger: XLVI or IXJ?

As of September 10, 2026, XLVI holds $25.47 M in assets under management (AUM), while IXJ manages $4.14 B.

What sectors do the XLVI and IXJ ETFs invest in?

XLVI leans toward sectors like Healthcare. Meanwhile, IXJ focuses on Healthcare.

What are the top holdings of the XLVI ETF and IXJ ETF?

XLVI top holdings include Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc.. IXJ holds in its top three: Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc..

XLVIvsIXJETF Comparison

State Street Health Care Select Sector SPDR Premium Income Fund

iShares Global Healthcare ETF

XLVI vs IXJ performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the XLVI and IXJ ETFs performed in 2026?

As of September 10, 2026, XLVI is up 5.69% year-to-date (YTD), while IXJ has returned 4.53%. That puts XLVI better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or IXJ?

Year-to-date, the XLVI ETF saw +$14M in flows, compared to -$505M for IXJ.

Which ETF is more volatile: XLVI or IXJ?

Over the past year, XLVI had a volatility of 11.09%, while IXJ experienced 15.84%.

Which ETF is bigger: XLVI or IXJ?

As of September 10, 2026, XLVI holds $25.47 M in assets under management (AUM), while IXJ manages $4.14 B.

What sectors do the XLVI and IXJ ETFs invest in?

XLVI leans toward sectors like Healthcare. Meanwhile, IXJ focuses on Healthcare.

What are the top holdings of the XLVI ETF and IXJ ETF?

XLVI top holdings include Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc.. IXJ holds in its top three: Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc..

Which ETF is more diversified: XLVI or IXJ?

XLVI holds 59 securities with 71.63% of its assets in the top 15. IXJ has 111 securities and a top 15 weight of 56.91%.

Healthcare Funds on the Rise

Healthcare Stocks Rebound

Continued tightening of the U.S. labor market

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