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XLVIvsIHEETF Comparison

ETF 1
XLVI

The Health Care Select Sector SPDR Premium Income Fund

This fund is part of
Options Strategies
-0.11%
Full XLVI fund page
VS
ETF 2
IHE

iShares U.S. Pharmaceuticals ETF

This fund is part of
US Health Care
-0.51%
Full IHE fund page

The Health Care Select Sector SPDR Premium Income Fund (XLVI) belongs to the Options Strategies segment. iShares U.S. Pharmaceuticals ETF (IHE) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. XLVI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.38% for IHE. XLVI is up 0.43% year-to-date (YTD) with +$2M in YTD flows. IHE performs better with 4.57% YTD performance, and +$133M in YTD flows. Run a side-by-side ETF comparison of XLVI and IHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XLVI vs IHE performance and flow charts

Performance

-2.0-1.00.01.02.03.0%Feb 10Feb 18Feb 25Mar 4

Cumulative Flows

0 M5 M10 M15 M20 MFeb 10Feb 18Feb 25Mar 4

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Historic performance and flows
Data as of 03/10/2026
1M3MYTD1Y3Y5Y
Perf.
XLVI
IHE
-0.34%-1.43%
+2.91%+7.02%
+0.43%+4.57%
n/a+27.21%
n/a+64.45%
n/a+63.29%
Flows
XLVI
IHE
+$788K+$14M
+$3M+$159M
+$2M+$133M
-+$252M
-+$364M
-+$397M
Volatility and drawdown
3M1Y3Y5Y
Volatility
XLVI
IHE
+10.28%+15.90%
n/a+20.44%
n/a+15.94%
n/a+15.80%
Max drawdown
XLVI
IHE
-3.26%-4.49%
n/a-14.18%
n/a-16.04%
n/a-16.12%
Max drawdown duration
XLVI
IHE
9d9d
n/a150d
n/a210d
n/a669d
Trading data

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XLVI
IHE
Last sale
3/11/2026 at 1:30 PM
$25.92
$88.40
Previous close
03/10/2026
$25.98
$88.62
Consolidated volume
03/10/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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XLVI
is actively managed and doesn’t replicate an index

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XLVI
IHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/11/2026 at 1:30 PM
Live
Closed
XLVI
IHE
Last price
$25.92
$88.40
1D performance
-0.23%
-0.25%
AuM$13.26 M$1.02 B
E/R0.35%0.38%
Characteristics
XLVI
IHE
Management strategyActivePassive
ProviderSPDRiShares
Benchmark-Dow Jones U.S. Select Pharmaceuticals Index
N° of holdings5746
Asset class-Equities
Trailing 12m distribution yield
Join
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Inception dateJuly 30, 2025May 1, 2006
ESGNoNo
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Exposure

Countries

XLVI
USA
96.37%
Other
3.63%
IHE
USA
90.92%
Other
9.08%

Sectors

XLVI
Health Care
97.65%
Other
2.35%
IHE
Health Care
96.19%
Other
3.81%
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Diversification

XLVI

Total weight of top 15 holdings out of 15

69.69%
IHE

Total weight of top 15 holdings out of 15

84.8%

Top 15 holdings

Data as of January 31, 2026
XLVI
LILLY
14.60%
JOHNSON&JOHNSON
9.71%
ABBVIE
6.99%
MERCK & CO INC
4.85%
UNITEDHEALTH GRP
4.61%
THERMO FISHER SCIENTIFIC
3.85%
ABBOTT LABS
3.37%
AMGEN-T
3.26%
INTUITIVE SURGICAL
3.17%
GILEAD SCIENCES
3.12%
PFIZER
2.66%
BOSTON SCIENTIFIC
2.46%
DANAHER
2.44%
MEDTRONIC PLC
2.34%
STRYKER
2.25%
IHE
JOHNSON&JOHNSON
23.72%
LILLY
22.21%
MERCK & CO INC
4.78%
BRISTOL-MYERS SQUIBB
4.57%
ZOETIS INC
4.44%
PFIZER
4.36%
ROYALTY PHARMA
4.08%
VIATRIS INC
4.00%
ELANCO ANIMAL HEALTH INC
3.20%
JAZZ PHARMACEUTICALS
2.65%
AXSOME THERA CMN STK
2.09%
CRINETICS PHARMACEUTICALS
1.41%
US45579U1097
1.15%
CORCEPT THERAPEUTICS
1.11%
LIGAND PHARMACEUTICALS
1.02%
Frequently asked questions about XLVI and IHE

How have the XLVI and IHE ETFs performed in 2026?

As of March 10, 2026, XLVI is up 0.43% year-to-date (YTD), while IHE has returned 4.57%. That puts IHE better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or IHE?

Year-to-date, the XLVI ETF saw +$2M in flows, compared to +$133M for IHE.

Which ETF is bigger: XLVI or IHE?

As of March 10, 2026, XLVI holds $13.26 M in assets under management (AUM), while IHE manages $1.02 B.

What sectors do the XLVI and IHE ETFs invest in?

XLVI leans toward sectors like Health Care. Meanwhile, IHE focuses on Health Care.

What are the top holdings of the XLVI ETF and IHE ETF?

XLVI top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. IHE holds in its top three: JOHNSON&JOHNSON, LILLY and MERCK & CO INC.

Which ETF is more diversified: XLVI or IHE?

XLVI holds 60 securities with 69.69% of its assets in the top 15. IHE has 56 securities and a top 15 weight of 84.8%.

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