XHEvsBBCETF Comparison
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State Street SPDR S&P Health Care Equipment ETF (XHE) belongs to the US Health Care segment. Virtus LifeSci Biotech Clinical Trials ETF (BBC) is part of the Tomorrow's Treatments segment. XHE's top 2 sector exposures are Healthcare and Finance. In contrast, BBC's top sector exposures are Healthcare. XHE is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.65% for BBC. XHE is up 5.71% year-to-date (YTD) with -$9M in YTD flows. BBC performs better with 10.7% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of XHE and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHE vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHE BBC | +1.69%-7.04% | +6.51%-13.67% | +5.71%+10.70% | +13.97%+36.99% | +39.19%+160.59% | -24.85%+1.02% |
| Flows | XHE BBC | -$40M- | -$10M- | -$9M+$5M | -$12M+$12M | -$223M+$16M | -$399M+$8M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHE BBC | +20.36%+36.77% | +22.70%+36.97% | +21.88%+37.66% | +24.86%+40.00% |
| Max drawdown | XHE BBC | -9.09%-29.70% | -18.20%-29.70% | -24.35%-54.25% | -49.37%-70.04% |
| Max drawdown duration | XHE BBC | 69d69d | 207d69d | 565d340d | 1819d1625d |
Trading data
XHE | BBC | |
Last sale 10/27/2026 at 1:30 PM | $93.25 | $42.87 |
| Previous close 10/27/2026 | $93.09 | $41.06 |
| Consolidated volume 10/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XHE | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
XHE | BBC | |
|---|---|---|
| Last price | $93.25 | $42.87 |
| 1D performance | +0.17% | +4.40% |
| AuM | $153.71 M | $40.68 M |
| E/R | 0.35% | 0.65% |
Characteristics
XHE | BBC | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | VIRTUS Investment Partners |
| Benchmark | S&P Health Care Equipment Select Industry Index | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 67 | 127 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 26, 2011 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
XHE
USA
93.57%
Other
6.43%
BBC
USA
87.24%
Other
12.76%
Sectors
XHE
Healthcare
97.47%
Other
2.53%
BBC
Healthcare
96.27%
Other
3.73%
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Diversification
XHE
Total weight of top 15 holdings out of 15
30.96%
BBC
Total weight of top 15 holdings out of 15
17.14%
Top 15 holdings
Data as of August 31, 2026
XHE
AtriCure, Inc.
2.59%
Strive, Inc. (United States)
2.47%
Inspire Medical Systems, Inc.
2.19%
Glaukos Corp.
2.16%
Butterfly Network, Inc.
2.15%
CONMED Corp.
2.02%
Integer Holdings Corp.
2.02%
Tandem Diabetes Care, Inc.
2.00%
Merit Medical Systems, Inc.
1.99%
Artivion, Inc.
1.94%
Haemonetics Corp.
1.93%
UFP Technologies, Inc.
1.89%
Baxter International, Inc.
1.88%
Becton, Dickinson & Co.
1.87%
Neogen Corp.
1.86%
BBC
Amylyx Pharmaceuticals, Inc.
1.50%
First Tracks Biotherapeutics, Inc.
1.48%
AbCellera Biologics, Inc.
1.38%
Xencor, Inc.
1.36%
Monopar Therapeutics, Inc.
1.12%
MBX Biosciences, Inc.
1.11%
uniQure NV
1.09%
Replimune Group, Inc.
1.06%
4D Molecular Therapeutics, Inc.
1.04%
SELLAS Life Sciences Group, Inc.
1.04%
Alto Neuroscience, Inc.
1.00%
LB Pharmaceuticals, Inc.
1.00%
Oric Pharmaceuticals, Inc.
0.99%
Zenas BioPharma, Inc.
0.98%
Cullinan Therapeutics, Inc.
0.98%
Frequently asked questions about XHE and BBC
How have the XHE and BBC ETFs performed in 2026?
As of October 27, 2026, XHE is up 5.71% year-to-date (YTD), while BBC has returned 10.7%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: XHE or BBC?
Year-to-date, the XHE ETF saw -$9M in flows, compared to +$5M for BBC.
Which ETF is more volatile: XHE or BBC?
Over the past year, XHE had a volatility of 22.7%, while BBC experienced 36.97%.
Which ETF is bigger: XHE or BBC?
As of October 27, 2026, XHE holds $153.71 M in assets under management (AUM), while BBC manages $40.68 M.
What sectors do the XHE and BBC ETFs invest in?
XHE leans toward sectors like Healthcare. Meanwhile, BBC focuses on Healthcare.
What are the top holdings of the XHE ETF and BBC ETF?
XHE top holdings include AtriCure, Inc., Strive, Inc. (United States) and Inspire Medical Systems, Inc.. BBC holds in its top three: Amylyx Pharmaceuticals, Inc., First Tracks Biotherapeutics, Inc. and AbCellera Biologics, Inc..
Which ETF is more diversified: XHE or BBC?
XHE holds 67 securities with 30.96% of its assets in the top 15. BBC has 127 securities and a top 15 weight of 17.14%.
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Latest news about XHE & BBC
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