XHEvsBBCETF Comparison
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State Street SPDR S&P Health Care Equipment ETF (XHE) belongs to the US Health Care segment. Virtus LifeSci Biotech Clinical Trials ETF (BBC) is part of the Tomorrow's Treatments segment. XHE's top 3 sector exposures are Healthcare and Finance. In contrast, BBC's top sector exposures are Healthcare XHE is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.65% for BBC. XHE is down -3.04% year-to-date (YTD) with +$2M in YTD flows. BBC performs better with 28.33% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of XHE and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHE vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHE BBC | +3.29%+1.30% | +3.26%+7.83% | -3.04%+28.33% | +8.72%+127.45% | -12.17%+114.85% | -31.68%+13.01% |
| Flows | XHE BBC | +$2M+$83K | +$26M+$7M | +$2M+$5M | -$18M+$11M | -$379M+$15M | -$397M+$6M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHE BBC | +26.19%+38.55% | +22.63%+35.78% | +22.18%+37.03% | +24.70%+39.66% |
| Max drawdown | XHE BBC | -6.40%-11.64% | -18.20%-14.64% | -32.21%-54.25% | -49.90%-70.93% |
| Max drawdown duration | XHE BBC | 43d54d | 197d60d | 1094d340d | 1786d1754d |
Trading data
XHE | BBC | |
Last sale 7/27/2026 at 1:30 PM | $87.54 | $49.74 |
| Previous close 07/24/2026 | $85.18 | $49.67 |
| Consolidated volume 07/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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XHE | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 1:30 PM
Live
Closed
XHE | BBC | |
|---|---|---|
| Last price | $87.54 | $49.74 |
| 1D performance | +2.77% | +0.14% |
| AuM | $151.67 M | $47.16 M |
| E/R | 0.35% | 0.65% |
Characteristics
XHE | BBC | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | VIRTUS Investment Partners |
| Benchmark | S&P Health Care Equipment Select Industry Index | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 67 | 125 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 26, 2011 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
XHE
USA
89.54%
Other
10.46%
BBC
USA
85.4%
Other
14.6%
Sectors
XHE
Healthcare
94.54%
Other
5.46%
BBC
Healthcare
95.19%
Other
4.81%
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Diversification
XHE
Total weight of top 15 holdings out of 15
26.73%
BBC
Total weight of top 15 holdings out of 15
14.01%
Top 15 holdings
Data as of June 30, 2026
XHE
Butterfly Network, Inc.
2.45%
QuidelOrtho Corp.
2.04%
Glaukos Corp.
1.79%
UFP Technologies, Inc.
1.79%
Axogen, Inc.
1.76%
Lantheus Holdings, Inc.
1.74%
Artivion, Inc.
1.73%
Envista Holdings Corp.
1.72%
Omnicell, Inc.
1.71%
Medline, Inc.
1.69%
Alphatec Holdings, Inc.
1.67%
Dentsply Sirona, Inc.
1.66%
Inspire Medical Systems, Inc.
1.66%
The Cooper Cos., Inc.
1.66%
Edwards Lifesciences Corp.
1.65%
BBC
uniQure NV
1.18%
REGENXBIO, Inc.
1.01%
Apogee Therapeutics, Inc.
0.99%
Monopar Therapeutics, Inc.
0.97%
Jade Biosciences, Inc.
0.94%
Aktis Oncology, Inc.
0.94%
MBX Biosciences, Inc.
0.94%
Biohaven Ltd.
0.90%
Cullinan Therapeutics, Inc.
0.89%
Kymera Therapeutics, Inc.
0.89%
SELLAS Life Sciences Group, Inc.
0.89%
Generate Biomedicines, Inc.
0.88%
Intellia Therapeutics, Inc.
0.87%
Nurix Therapeutics, Inc.
0.87%
4D Molecular Therapeutics, Inc.
0.86%
Frequently asked questions about XHE and BBC
How have the XHE and BBC ETFs performed in 2026?
As of July 24, 2026, XHE is down -3.04% year-to-date (YTD), while BBC has returned 28.33%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: XHE or BBC?
Year-to-date, the XHE ETF saw +$2M in flows, compared to +$5M for BBC.
Which ETF is more volatile: XHE or BBC?
Over the past year, XHE had a volatility of 22.63%, while BBC experienced 35.78%.
Which ETF is bigger: XHE or BBC?
As of July 24, 2026, XHE holds $151.67 M in assets under management (AUM), while BBC manages $47.16 M.
What sectors do the XHE and BBC ETFs invest in?
XHE leans toward sectors like Healthcare. Meanwhile, BBC focuses on Healthcare.
What are the top holdings of the XHE ETF and BBC ETF?
XHE top holdings include Butterfly Network, Inc., QuidelOrtho Corp. and Glaukos Corp.. BBC holds in its top three: uniQure NV, REGENXBIO, Inc. and Apogee Therapeutics, Inc..
Which ETF is more diversified: XHE or BBC?
XHE holds 67 securities with 26.73% of its assets in the top 15. BBC has 125 securities and a top 15 weight of 14.01%.
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Latest news about XHE & BBC
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