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WDNAvsHRTSETF Comparison

ETF 1

WDNA

WisdomTree BioRevolution Fund

This fund is part of

BioTech & Genomics

-0.12%

Full WDNA fund page

VS

ETF 2

HRTS

Tema GLP-1, Obesity & Cardiometabolic ETF

This fund is part of

Tomorrow's Treatments

-0.74%

Full HRTS fund page

WisdomTree BioRevolution Fund (WDNA) belongs to the BioTech & Genomics segment. Tema GLP-1, Obesity & Cardiometabolic ETF (HRTS) is part of the Tomorrow's Treatments segment. WDNA's top 3 sector exposures are Health Care, Materials and Consumer Staples. In contrast, HRTS's top sector exposures are Health Care, WDNA is less expensive with a Total Expense Ratio (TER) of 0.45%, versus 0.99% for HRTS. WDNA is up 4.41% year-to-date (YTD) with -$357K in YTD flows. HRTS performs worse with -6.25% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of WDNA and HRTS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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WDNA vs HRTS performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 04/27/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	WDNA HRTS	+5.78%+1.43%	-4.95%-8.36%	+4.41%-6.25%	+41.36%+16.87%	+11.54%n/a	n/an/a
Flows	WDNA HRTS	--$1M	-$357K-$4M	-$357K-$2M	-$357K-$12M	-$524K-	--

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	WDNA HRTS	+24.01%+16.53%	+26.79%+16.33%	+24.80%n/a	n/an/a
Max drawdown	WDNA HRTS	-10.14%-9.68%	-11.90%-10.68%	-37.80%n/a	n/an/a
Max drawdown duration	WDNA HRTS	79d57d	95d110d	901dn/a	n/an/a

Trading data

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	WDNA	HRTS
Last sale 4/28/2026 at 1:30 PM	$17.65	$33.15
Previous close 04/27/2026	$17.70	$33.10
Consolidated volume 04/27/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of April 29, 2026

1-year trailing difference

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HRTS

is actively managed and doesn’t replicate an index

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	WDNA	HRTS
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 4/28/2026 at 1:30 PM

Live

Closed

	WDNA	HRTS
Last price	$17.65	$33.15
1D performance	-0.28%	+0.15%
AuM	$2.30 M	$49.35 M
E/R	0.45%	0.99%

Characteristics

	WDNA	HRTS
Management strategy	Passive	Active
Provider	WisdomTree	Tema
Benchmark	WisdomTree BioRevolution Index	-
N° of holdings	75	38
Asset class	Equities	-
Trailing 12m distribution yield	Join	Join
Inception date	June 3, 2021	November 21, 2023
ESG	No	No

More WDNA data on Trackinsight

More HRTS data on Trackinsight

Exposure

Countries

WDNA

USA

80.59%

Other

19.41%

HRTS

USA

82.47%

Other

17.53%

Sectors

WDNA

Health Care

82.52%

Other

17.48%

HRTS

Health Care

87.86%

Other

12.14%

Diversification

WDNA

Total weight of top 15 holdings out of 15

38.65%

HRTS

Total weight of top 15 holdings out of 15

61.52%

Top 15 holdings

Data as of March 31, 2026

WDNA

MODERNA INC

4.49%

JOHNSON&JOHNSON

3.26%

UTD THERAPEUT

2.90%

PFIZER

2.82%

LILLY

2.65%

STOKE THERAPEUTICS INC

2.57%

NATERA

2.46%

AMGEN-T

2.43%

ASTRAZENECA

2.34%

AMICUS THERAPEUTICS

2.28%

TWIST BIOSCIENCE CORP

2.20%

BIONTECH SE ADR

2.09%

US86366E1064

2.09%

IONIS PHARMACEUTICALS INC

2.07%

GILEAD SCIENCES

2.00%

HRTS

LILLY

9.70%

JOHNSON&JOHNSON

4.97%

US7711951043

4.94%

ASTRAZENECA

4.91%

MERCK & CO INC

4.46%

THERMO FISHER SCIENTIFIC

4.06%

UNITEDHEALTH GRP

3.79%

GILEAD SCIENCES

3.66%

NOVARTIS

3.52%

VERTEX PHARMACEUTICALS

3.30%

ABBOTT LABS

3.26%

ABBVIE

3.00%

BRIDGEBIO PHARMA

2.85%

DANAHER

2.81%

BRISTOL-MYERS SQUIBB

2.29%

Frequently asked questions about WDNA and HRTS

How have the WDNA and HRTS ETFs performed in 2026?

As of April 27, 2026, WDNA is up 4.41% year-to-date (YTD), while HRTS has lost -6.25%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: WDNA or HRTS?

Year-to-date, the WDNA ETF saw -$357K in flows, compared to -$2M for HRTS.

Which ETF is more volatile: WDNA or HRTS?

Over the past year, WDNA had a volatility of 26.79%, while HRTS experienced 16.33%.

Which ETF is bigger: WDNA or HRTS?

As of April 27, 2026, WDNA holds $2.30 M in assets under management (AUM), while HRTS manages $49.35 M.

What sectors do the WDNA and HRTS ETFs invest in?

WDNA leans toward sectors like Health Care. Meanwhile, HRTS focuses on Health Care.

What are the top holdings of the WDNA ETF and HRTS ETF?

WDNA top holdings include MODERNA INC, JOHNSON&JOHNSON and UTD THERAPEUT. HRTS holds in its top three: LILLY, JOHNSON&JOHNSON and US7711951043.

Which ETF is more diversified: WDNA or HRTS?

WDNA holds 84 securities with 38.65% of its assets in the top 15. HRTS has 44 securities and a top 15 weight of 61.52%.

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HRTS

Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?

April 18, 2024

HRTS

WDNAvsHRTSETF Comparison

WisdomTree BioRevolution Fund

Tema GLP-1, Obesity & Cardiometabolic ETF

WDNA vs HRTS performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the WDNA and HRTS ETFs performed in 2026?

As of April 27, 2026, WDNA is up 4.41% year-to-date (YTD), while HRTS has lost -6.25%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: WDNA or HRTS?

Year-to-date, the WDNA ETF saw -$357K in flows, compared to -$2M for HRTS.

Which ETF is more volatile: WDNA or HRTS?

Over the past year, WDNA had a volatility of 26.79%, while HRTS experienced 16.33%.

Which ETF is bigger: WDNA or HRTS?

As of April 27, 2026, WDNA holds $2.30 M in assets under management (AUM), while HRTS manages $49.35 M.

What sectors do the WDNA and HRTS ETFs invest in?

WDNA leans toward sectors like Health Care. Meanwhile, HRTS focuses on Health Care.

What are the top holdings of the WDNA ETF and HRTS ETF?

WDNA top holdings include MODERNA INC, JOHNSON&JOHNSON and UTD THERAPEUT. HRTS holds in its top three: LILLY, JOHNSON&JOHNSON and US7711951043.

Which ETF is more diversified: WDNA or HRTS?

WDNA holds 84 securities with 38.65% of its assets in the top 15. HRTS has 44 securities and a top 15 weight of 61.52%.

A Deep Dive into the New Amplify Weight Loss Drug & Treatment ETF (THNR)

Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?

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