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PBPHvsHRTSETF Comparison

ETF 1

PBPH

Portfolio Building Block World Pharma and Biotech Index ETF

This fund is part of

DM Large & Mid Cap

-0.17%

Full PBPH fund page

VS

ETF 2

HRTS

Tema GLP-1, Obesity & Cardiometabolic ETF

This fund is part of

Tomorrow's Treatments

-0.42%

Full HRTS fund page

Portfolio Building Block World Pharma and Biotech Index ETF (PBPH) belongs to the DM Large & Mid Cap segment. Tema GLP-1, Obesity & Cardiometabolic ETF (HRTS) is part of the Tomorrow's Treatments segment. PBPH's top 3 sector exposures are Health Care and Consumer Staples. In contrast, HRTS's top sector exposures are Health Care PBPH is less expensive with a Total Expense Ratio (TER) of 0.13%, versus 0.99% for HRTS. PBPH is down -3.66% year-to-date (YTD) with +$805M in YTD flows. HRTS performs worse with -5.16% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of PBPH and HRTS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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PBPH vs HRTS performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 04/29/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	PBPH HRTS	-2.78%-1.32%	-6.40%-6.82%	-3.66%-5.16%	n/a+18.38%	n/an/a	n/an/a
Flows	PBPH HRTS	+$56M-$1M	+$774M-$4M	+$805M-$2M	--$12M	--	--

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	PBPH HRTS	+16.41%+17.14%	n/a+16.35%	n/an/a	n/an/a
Max drawdown	PBPH HRTS	-10.81%-9.68%	n/a-10.68%	n/an/a	n/an/a
Max drawdown duration	PBPH HRTS	71d61d	n/a114d	n/an/a	n/an/a

Trading data

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	PBPH	HRTS
Last sale 5/1/2026 at 1:30 PM	$24.97	$33.55
Previous close 04/29/2026	$25.05	$33.66
Consolidated volume 04/29/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of April 29, 2026

1-year trailing difference

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HRTS

is actively managed and doesn’t replicate an index

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	PBPH	HRTS
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 5/1/2026 at 1:30 PM

Live

Closed

	PBPH	HRTS
Last price	$24.97	$33.55
1D performance	-0.34%	-0.33%
AuM	$736.56 M	$49.93 M
E/R	0.13%	0.99%

Characteristics

	PBPH	HRTS
Management strategy	Passive	Active
Provider	Tidal	Tema
Benchmark	BITA Global Pharma and Biotech Select Index	-
N° of holdings	49	38
Asset class	-	-
Trailing 12m distribution yield	Join	Join
Inception date	November 24, 2025	November 21, 2023
ESG	No	No

More PBPH data on Trackinsight

More HRTS data on Trackinsight

Exposure

Countries

PBPH

USA

63.05%

Switzerland

10.48%

Other

26.47%

HRTS

USA

82.47%

Other

17.53%

Sectors

PBPH

Health Care

85.65%

Other

14.35%

HRTS

Health Care

87.86%

Other

12.14%

Diversification

PBPH

Total weight of top 15 holdings out of 15

71.34%

HRTS

Total weight of top 15 holdings out of 15

61.52%

Top 15 holdings

Data as of March 31, 2026

PBPH

LILLY

12.31%

JOHNSON&JOHNSON

9.59%

ABBVIE

6.19%

MERCK & CO INC

4.79%

NOVARTIS

4.64%

CH1499059983

4.47%

GILEAD SCIENCES

4.42%

AMGEN-T

4.38%

PFIZER

4.13%

BRISTOL-MYERS SQUIBB

3.18%

DK0062498333

2.96%

VERTEX PHARMACEUTICALS

2.94%

SANOFI SA

2.68%

GSK PLC

2.67%

REGENERON PHARMACEUTICALS

2.00%

HRTS

LILLY

9.70%

JOHNSON&JOHNSON

4.97%

US7711951043

4.94%

ASTRAZENECA

4.91%

MERCK & CO INC

4.46%

THERMO FISHER SCIENTIFIC

4.06%

UNITEDHEALTH GRP

3.79%

GILEAD SCIENCES

3.66%

NOVARTIS

3.52%

VERTEX PHARMACEUTICALS

3.30%

ABBOTT LABS

3.26%

ABBVIE

3.00%

BRIDGEBIO PHARMA

2.85%

DANAHER

2.81%

MEDTRONIC PLC

2.29%

Frequently asked questions about PBPH and HRTS

How have the PBPH and HRTS ETFs performed in 2026?

As of April 29, 2026, PBPH is down -3.66% year-to-date (YTD), while HRTS has lost -5.16%. That puts PBPH better performer ahead so far this year.

Which ETF is attracting more investor money: PBPH or HRTS?

Year-to-date, the PBPH ETF saw +$805M in flows, compared to -$2M for HRTS.

Which ETF is bigger: PBPH or HRTS?

As of April 29, 2026, PBPH holds $736.56 M in assets under management (AUM), while HRTS manages $49.93 M.

What sectors do the PBPH and HRTS ETFs invest in?

PBPH leans toward sectors like Health Care. Meanwhile, HRTS focuses on Health Care.

What are the top holdings of the PBPH ETF and HRTS ETF?

PBPH top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. HRTS holds in its top three: LILLY, JOHNSON&JOHNSON and US7711951043.

Which ETF is more diversified: PBPH or HRTS?

PBPH holds 52 securities with 71.34% of its assets in the top 15. HRTS has 44 securities and a top 15 weight of 61.52%.

A Deep Dive into the New Amplify Weight Loss Drug & Treatment ETF (THNR)

June 7, 2024

HRTS

Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?

April 18, 2024

HRTS

PBPHvsHRTSETF Comparison

Portfolio Building Block World Pharma and Biotech Index ETF

Tema GLP-1, Obesity & Cardiometabolic ETF

PBPH vs HRTS performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the PBPH and HRTS ETFs performed in 2026?

As of April 29, 2026, PBPH is down -3.66% year-to-date (YTD), while HRTS has lost -5.16%. That puts PBPH better performer ahead so far this year.

Which ETF is attracting more investor money: PBPH or HRTS?

Year-to-date, the PBPH ETF saw +$805M in flows, compared to -$2M for HRTS.

Which ETF is bigger: PBPH or HRTS?

As of April 29, 2026, PBPH holds $736.56 M in assets under management (AUM), while HRTS manages $49.93 M.

What sectors do the PBPH and HRTS ETFs invest in?

PBPH leans toward sectors like Health Care. Meanwhile, HRTS focuses on Health Care.

What are the top holdings of the PBPH ETF and HRTS ETF?

PBPH top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. HRTS holds in its top three: LILLY, JOHNSON&JOHNSON and US7711951043.

Which ETF is more diversified: PBPH or HRTS?

PBPH holds 52 securities with 71.34% of its assets in the top 15. HRTS has 44 securities and a top 15 weight of 61.52%.

A Deep Dive into the New Amplify Weight Loss Drug & Treatment ETF (THNR)

Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?

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