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PBEvsIHEETF Comparison

ETF 1

PBE

Invesco Dynamic Biotechnology & Genome ETF

This fund is part of

BioTech & Genomics

+4.79%

Full PBE fund page

VS

ETF 2

IHE

iShares U.S. Pharmaceuticals ETF

This fund is part of

US Health Care

+0.44%

Full IHE fund page

Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. iShares U.S. Pharmaceuticals ETF (IHE) is part of the US Health Care segment. PBE's top 1 sector exposures are Healthcare. In contrast, IHE's top sector exposures are Healthcare and Non-Corporate. PBE is more expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.37% for IHE. PBE is up 24.01% year-to-date (YTD) with +$113M in YTD flows. IHE performs worse with 23.1% YTD performance, and +$505M in YTD flows. Run a side-by-side ETF comparison of PBE and IHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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PBE vs IHE performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 10/27/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	PBE IHE	+3.48%+0.31%	+12.22%+0.74%	+24.01%+23.10%	+38.47%+39.85%	+95.94%+95.36%	+38.86%+82.88%
Flows	PBE IHE	-$947K-$119M	+$111M-$36M	+$113M+$505M	+$115M+$669M	+$62M+$694M	+$65M+$759M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	PBE IHE	+21.55%+18.62%	+20.01%+18.67%	+20.60%+17.18%	+22.69%+16.77%
Max drawdown	PBE IHE	-5.97%-9.67%	-11.70%-9.67%	-22.21%-16.04%	-32.63%-16.12%
Max drawdown duration	PBE IHE	46d69d	166d69d	324d210d	1468d669d

Trading data

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	PBE	IHE
Last sale 10/28/2026 at 1:30 PM	$101.87	$103.67
Previous close 10/27/2026	$100.74	$103.35
Consolidated volume 10/27/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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	PBE	IHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/28/2026 at 1:30 PM

Live

Closed

	PBE	IHE
Last price	$101.87	$103.67
1D performance	+1.12%	+0.31%
AuM	$438.13 M	$1.56 B
E/R	0.59%	0.37%

Characteristics

	PBE	IHE
Management strategy	Passive	Passive
Provider	Invesco	iShares
Benchmark	Dynamic Biotech & Genome Intellidex Index	Dow Jones U.S. Select Pharmaceuticals Index
N° of holdings	30	57
Asset class	Equities	Equities
Trailing 12m distribution yield	Join	Join
Inception date	June 23, 2005	May 1, 2006
ESG	No	No

More PBE data on Trackinsight

More IHE data on Trackinsight

Exposure

Countries

PBE

USA

97.22%

Other

2.78%

IHE

USA

95.75%

Other

4.25%

Sectors

PBE

Healthcare

100%

Other

0%

IHE

Healthcare

99.75%

Other

0.25%

Diversification

PBE

Total weight of top 15 holdings out of 15

63.67%

IHE

Total weight of top 15 holdings out of 15

84.42%

Top 15 holdings

Data as of August 31, 2026

PBE

CareDx, Inc.

5.49%

Amgen, Inc.

5.38%

Regeneron Pharmaceuticals, Inc.

5.26%

Vertex Pharmaceuticals, Inc.

5.21%

Royalty Pharma Plc

4.76%

Biogen, Inc.

4.75%

Gilead Sciences, Inc.

4.61%

United Therapeutics Corp.

3.77%

Omeros Corp.

3.73%

Repligen Corp.

3.57%

Illumina, Inc.

3.54%

Halozyme Therapeutics, Inc.

3.51%

Bio-Techne Corp.

3.41%

Protagonist Therapeutics, Inc.

3.37%

Alnylam Pharmaceuticals, Inc.

3.31%

IHE

Johnson & Johnson

22.45%

Eli Lilly & Co.

20.50%

Merck & Co., Inc.

5.00%

Bristol Myers Squibb Co.

4.84%

Royalty Pharma Plc

4.54%

Pfizer Inc.

4.48%

Viatris, Inc.

4.19%

Zoetis, Inc.

3.82%

Jazz Pharmaceuticals Plc

3.43%

Elanco Animal Health, Inc.

2.61%

Corcept Therapeutics, Inc.

2.36%

Crinetics Pharmaceuticals, Inc.

1.95%

Axsome Therapeutics, Inc.

1.87%

Ligand Pharmaceuticals, Inc.

1.24%

Definium Therapeutics, Inc.

1.12%

Frequently asked questions about PBE and IHE

How have the PBE and IHE ETFs performed in 2026?

As of October 27, 2026, PBE is up 24.01% year-to-date (YTD), while IHE has returned 23.1%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or IHE?

Year-to-date, the PBE ETF saw +$113M in flows, compared to +$505M for IHE.

Which ETF is more volatile: PBE or IHE?

Over the past year, PBE had a volatility of 20.01%, while IHE experienced 18.67%.

Which ETF is bigger: PBE or IHE?

As of October 27, 2026, PBE holds $438.13 M in assets under management (AUM), while IHE manages $1.56 B.

What sectors do the PBE and IHE ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, IHE focuses on Healthcare.

What are the top holdings of the PBE ETF and IHE ETF?

PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. IHE holds in its top three: Johnson & Johnson, Eli Lilly & Co. and Merck & Co., Inc..

PBEvsIHEETF Comparison

Invesco Dynamic Biotechnology & Genome ETF

iShares U.S. Pharmaceuticals ETF

PBE vs IHE performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the PBE and IHE ETFs performed in 2026?

As of October 27, 2026, PBE is up 24.01% year-to-date (YTD), while IHE has returned 23.1%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or IHE?

Year-to-date, the PBE ETF saw +$113M in flows, compared to +$505M for IHE.

Which ETF is more volatile: PBE or IHE?

Over the past year, PBE had a volatility of 20.01%, while IHE experienced 18.67%.

Which ETF is bigger: PBE or IHE?

As of October 27, 2026, PBE holds $438.13 M in assets under management (AUM), while IHE manages $1.56 B.

What sectors do the PBE and IHE ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, IHE focuses on Healthcare.

What are the top holdings of the PBE ETF and IHE ETF?

PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. IHE holds in its top three: Johnson & Johnson, Eli Lilly & Co. and Merck & Co., Inc..

Which ETF is more diversified: PBE or IHE?

PBE holds 30 securities with 63.67% of its assets in the top 15. IHE has 57 securities and a top 15 weight of 84.42%.

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