OZEMvsMEDXETF Comparison
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Roundhill GLP-1 & Weight Loss ETF (OZEM) and Horizon Kinetics Medical ETF (MEDX) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Healthcare. OZEM is less expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.85% for MEDX. OZEM is down -4.17% year-to-date (YTD) with +$22M in YTD flows. MEDX performs better with 8.22% YTD performance, and -$3M in YTD flows. Run a side-by-side ETF comparison of OZEM and MEDX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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OZEM vs MEDX performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | OZEM MEDX | +0.15%-3.03% | +6.60%+12.56% | -4.17%+8.22% | +24.59%+31.02% | n/a+28.80% | n/an/a |
| Flows | OZEM MEDX | +$10M-$883K | +$9M-$2M | +$22M-$3M | +$22M-$3M | --$4M | -- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | OZEM MEDX | +21.48%+21.02% | +22.70%+18.55% | n/a+17.31% | n/an/a |
| Max drawdown | OZEM MEDX | -6.63%-7.93% | -19.51%-10.65% | n/a-23.05% | n/an/a |
| Max drawdown duration | OZEM MEDX | 51d21d | 183d115d | n/a393d | n/an/a |
Trading data
OZEM | MEDX | |
Last sale 7/29/2026 at 1:30 PM | $32.66 | $35.80 |
| Previous close 07/28/2026 | $32.81 | $36.03 |
| Consolidated volume 07/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 7/29/2026 at 1:30 PM
Live
Closed
OZEM | MEDX | |
|---|---|---|
| Last price | $32.66 | $35.80 |
| 1D performance | -0.46% | -0.63% |
| AuM | $63.07 M | $17.80 M |
| E/R | 0.59% | 0.85% |
Characteristics
OZEM | MEDX | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Roundhill Investments | Horizon Kinetics LLC |
| Benchmark | - | - |
| N° of holdings | 24 | 30 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | May 21, 2024 | January 27, 2023 |
| ESG | No | No |
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Exposure
Countries
OZEM
USA
44.42%
Denmark
19.13%
China
16.37%
Other
20.08%
MEDX
USA
68.17%
Switzerland
10.22%
United Kingdom
8.49%
Other
13.12%
Sectors
OZEM
Healthcare
99.56%
Other
0.44%
MEDX
Healthcare
92.67%
Other
7.33%
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Diversification
OZEM
Total weight of top 15 holdings out of 15
82.24%
MEDX
Total weight of top 15 holdings out of 15
81.88%
Top 15 holdings
Data as of June 30, 2026
OZEM
Novo Nordisk A/S
13.29%
Eli Lilly & Co.
13.07%
Pfizer Inc.
6.58%
Kailera Therapeutics, Inc.
6.00%
Viking Therapeutics, Inc.
5.84%
CSPC Pharmaceutical Group Ltd.
5.22%
Chugai Pharmaceutical Co., Ltd.
4.53%
Ascletis Pharma, Inc.
3.95%
Zealand Pharma A/S
3.93%
AstraZeneca PLC
3.89%
Amgen, Inc.
3.89%
Hanmi Pharmaceutical Co., Ltd.
3.33%
Roche Holding AG
3.12%
Structure Therapeutics, Inc.
2.89%
MBX Biosciences, Inc.
2.71%
MEDX
Eli Lilly & Co.
18.51%
AbbVie, Inc.
8.87%
Novartis AG
6.80%
Alkermes Plc
5.79%
Johnson & Johnson
5.58%
AstraZeneca PLC
4.93%
Ionis Pharmaceuticals, Inc.
4.62%
Bristol Myers Squibb Co.
4.40%
Merck & Co., Inc.
3.94%
Amgen, Inc.
3.86%
Alnylam Pharmaceuticals, Inc.
3.30%
Biogen, Inc.
3.07%
Pfizer Inc.
2.87%
GSK Plc
2.70%
CRISPR Therapeutics AG
2.64%
Frequently asked questions about OZEM and MEDX
How have the OZEM and MEDX ETFs performed in 2026?
As of July 28, 2026, OZEM is down -4.17% year-to-date (YTD), while MEDX has returned 8.22%. That puts MEDX better performer ahead so far this year.
Which ETF is attracting more investor money: OZEM or MEDX?
Year-to-date, the OZEM ETF saw +$22M in flows, compared to -$3M for MEDX.
Which ETF is more volatile: OZEM or MEDX?
Over the past year, OZEM had a volatility of 22.7%, while MEDX experienced 18.55%.
Which ETF is bigger: OZEM or MEDX?
As of July 28, 2026, OZEM holds $63.07 M in assets under management (AUM), while MEDX manages $17.80 M.
What sectors do the OZEM and MEDX ETFs invest in?
OZEM leans toward sectors like Healthcare. Meanwhile, MEDX focuses on Healthcare.
What are the top holdings of the OZEM ETF and MEDX ETF?
OZEM top holdings include Novo Nordisk A/S, Eli Lilly & Co. and Pfizer Inc.. MEDX holds in its top three: Eli Lilly & Co., AbbVie, Inc. and Novartis AG.
Which ETF is more diversified: OZEM or MEDX?
OZEM holds 24 securities with 82.24% of its assets in the top 15. MEDX has 30 securities and a top 15 weight of 81.88%.
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Latest news about OZEM & MEDX
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