OZEMvsHRTSETF Comparison
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Roundhill GLP-1 & Weight Loss ETF (OZEM) and Tema GLP-1, Obesity & Cardiometabolic ETF (HRTS) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Healthcare. OZEM is less expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.99% for HRTS. OZEM is down -4.17% year-to-date (YTD) with +$22M in YTD flows. HRTS performs better with 5.78% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of OZEM and HRTS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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OZEM vs HRTS performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | OZEM HRTS | +0.15%+1.97% | +6.60%+12.66% | -4.17%+5.78% | +24.59%+30.47% | n/an/a | n/an/a |
| Flows | OZEM HRTS | +$10M- | +$9M-$70K | +$22M-$2M | +$22M-$6M | -- | -- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | OZEM HRTS | +21.48%+18.07% | +22.70%+16.11% | n/an/a | n/an/a |
| Max drawdown | OZEM HRTS | -6.63%-4.69% | -19.51%-10.68% | n/an/a | n/an/a |
| Max drawdown duration | OZEM HRTS | 51d21d | 183d170d | n/an/a | n/an/a |
Trading data
OZEM | HRTS | |
Last sale 7/29/2026 at 1:30 PM | $32.66 | $37.24 |
| Previous close 07/28/2026 | $32.81 | $37.39 |
| Consolidated volume 07/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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Main metrics
Last update 7/29/2026 at 1:30 PM
Live
Closed
OZEM | HRTS | |
|---|---|---|
| Last price | $32.66 | $37.24 |
| 1D performance | -0.46% | -0.39% |
| AuM | $63.07 M | $55.69 M |
| E/R | 0.59% | 0.99% |
Characteristics
OZEM | HRTS | |
|---|---|---|
| Management strategy | Active | Active |
| Provider | Roundhill Investments | Tema |
| Benchmark | - | - |
| N° of holdings | 24 | 43 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | May 21, 2024 | November 21, 2023 |
| ESG | No | No |
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Exposure
Countries
OZEM
USA
44.42%
Denmark
19.13%
China
16.37%
Other
20.08%
HRTS
USA
76.55%
Switzerland
7.26%
Other
16.19%
Sectors
OZEM
Healthcare
99.56%
Other
0.44%
HRTS
Healthcare
99.57%
Other
0.43%
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Diversification
OZEM
Total weight of top 15 holdings out of 15
82.24%
HRTS
Total weight of top 15 holdings out of 15
64.29%
Top 15 holdings
Data as of June 30, 2026
OZEM
Novo Nordisk A/S
13.29%
Eli Lilly & Co.
13.07%
Pfizer Inc.
6.58%
Kailera Therapeutics, Inc.
6.00%
Viking Therapeutics, Inc.
5.84%
CSPC Pharmaceutical Group Ltd.
5.22%
Chugai Pharmaceutical Co., Ltd.
4.53%
Ascletis Pharma, Inc.
3.95%
Zealand Pharma A/S
3.93%
AstraZeneca PLC
3.89%
Amgen, Inc.
3.89%
Hanmi Pharmaceutical Co., Ltd.
3.33%
Roche Holding AG
3.12%
Structure Therapeutics, Inc.
2.89%
MBX Biosciences, Inc.
2.71%
HRTS
Eli Lilly & Co.
11.91%
UnitedHealth Group, Inc.
5.58%
Novo Nordisk A/S
5.25%
Merck & Co., Inc.
4.11%
Roche Holding AG
3.96%
Thermo Fisher Scientific, Inc.
3.91%
AstraZeneca PLC
3.85%
Johnson & Johnson
3.84%
Revolution Medicines, Inc.
3.64%
Cytokinetics, Inc.
3.40%
Novartis AG
3.30%
Gilead Sciences, Inc.
3.09%
Vertex Pharmaceuticals, Inc.
3.04%
Abbott Laboratories
2.71%
Danaher Corp.
2.70%
Frequently asked questions about OZEM and HRTS
How have the OZEM and HRTS ETFs performed in 2026?
As of July 28, 2026, OZEM is down -4.17% year-to-date (YTD), while HRTS has returned 5.78%. That puts HRTS better performer ahead so far this year.
Which ETF is attracting more investor money: OZEM or HRTS?
Year-to-date, the OZEM ETF saw +$22M in flows, compared to -$2M for HRTS.
Which ETF is more volatile: OZEM or HRTS?
Over the past year, OZEM had a volatility of 22.7%, while HRTS experienced 16.11%.
Which ETF is bigger: OZEM or HRTS?
As of July 28, 2026, OZEM holds $63.07 M in assets under management (AUM), while HRTS manages $55.69 M.
What sectors do the OZEM and HRTS ETFs invest in?
OZEM leans toward sectors like Healthcare. Meanwhile, HRTS focuses on Healthcare.
What are the top holdings of the OZEM ETF and HRTS ETF?
OZEM top holdings include Novo Nordisk A/S, Eli Lilly & Co. and Pfizer Inc.. HRTS holds in its top three: Eli Lilly & Co., UnitedHealth Group, Inc. and Novo Nordisk A/S.
Which ETF is more diversified: OZEM or HRTS?
OZEM holds 24 securities with 82.24% of its assets in the top 15. HRTS has 43 securities and a top 15 weight of 64.29%.
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Latest news about OZEM & HRTS
A Deep Dive into the New Amplify Weight Loss Drug & Treatment ETF (THNR)
June 7, 2024
OZEM
HRTS
Obesity and Weight-Loss Drugs: A New Thematic ETF Segment?
April 18, 2024
HRTS
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