OZEMvsASDETF Comparison
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Roundhill GLP-1 & Weight Loss ETF (OZEM) and Defiance Autism Impact ETF (ASD) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Healthcare. OZEM is less expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.79% for ASD. Run a side-by-side ETF comparison of OZEM and ASD below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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OZEM vs ASD performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/29/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | OZEM ASD | +0.19%+0.32% | +8.57%n/a | -4.14%n/a | +31.52%n/a | n/an/a | n/an/a |
| Flows | OZEM ASD | +$10M- | +$9M- | +$22M- | +$22M- | -- | -- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | OZEM ASD | +21.12%n/a | +22.06%n/a | n/an/a | n/an/a |
| Max drawdown | OZEM ASD | -6.63%n/a | -19.51%n/a | n/an/a | n/an/a |
| Max drawdown duration | OZEM ASD | 51dn/a | 184dn/a | n/an/a | n/an/a |
Trading data
OZEM | ASD | |
Last sale 7/30/2026 at 1:30 PM | $32.52 | $27.04 |
| Previous close 07/29/2026 | $32.66 | $26.99 |
| Consolidated volume 07/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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OZEM
is actively managed and doesn’t replicate an indexOZEM | ASD | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/30/2026 at 1:30 PM
Live
Closed
OZEM | ASD | |
|---|---|---|
| Last price | $32.52 | $27.04 |
| 1D performance | -0.44% | +0.17% |
| AuM | $63.09 M | $1.35 M |
| E/R | 0.59% | 0.79% |
Characteristics
OZEM | ASD | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Roundhill Investments | Defiance ETFs |
| Benchmark | - | VettaFi Autism Impact Index |
| N° of holdings | 24 | 37 |
| Asset class | - | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | May 21, 2024 | May 29, 2026 |
| ESG | No | No |
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Exposure
Countries
OZEM
USA
44.42%
Denmark
19.13%
China
16.37%
Other
20.08%
ASD
USA
52.48%
Japan
10.29%
Other
37.23%
Sectors
OZEM
Healthcare
99.56%
Other
0.44%
ASD
Healthcare
82.88%
Consumer Non-Cycl.
12.26%
Other
4.86%
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Diversification
OZEM
Total weight of top 15 holdings out of 15
82.24%
ASD
Total weight of top 15 holdings out of 15
41.3%
Top 15 holdings
Data as of June 30, 2026
OZEM
Novo Nordisk A/S
13.29%
Eli Lilly & Co.
13.07%
Pfizer Inc.
6.58%
Kailera Therapeutics, Inc.
6.00%
Viking Therapeutics, Inc.
5.84%
CSPC Pharmaceutical Group Ltd.
5.22%
Chugai Pharmaceutical Co., Ltd.
4.53%
Ascletis Pharma, Inc.
3.95%
Zealand Pharma A/S
3.93%
Amgen, Inc.
3.89%
AstraZeneca PLC
3.89%
Hanmi Pharmaceutical Co., Ltd.
3.33%
Roche Holding AG
3.12%
Structure Therapeutics, Inc.
2.89%
MBX Biosciences, Inc.
2.71%
ASD
Otsuka Holdings Co., Ltd.
3.03%
Lifestance Health Group, Inc.
2.98%
ACADIA Pharmaceuticals, Inc.
2.95%
AbbVie, Inc.
2.79%
Revvity, Inc.
2.78%
Repligen Corp.
2.75%
Acadia Healthcare Co., Inc.
2.75%
MapLight Therapeutics, Inc.
2.73%
BrightSpring Health Services, Inc.
2.73%
Bright Horizons Family Solutions, Inc.
2.68%
Johnson & Johnson
2.65%
Medicover AB
2.65%
BioMarin Pharmaceutical, Inc.
2.65%
Anavex Life Sciences Corp.
2.61%
Roche Holding AG
2.57%
Frequently asked questions about OZEM and ASD
Which ETF is bigger: OZEM or ASD?
As of July 29, 2026, OZEM holds $63.09 M in assets under management (AUM), while ASD manages $1.35 M.
What sectors do the OZEM and ASD ETFs invest in?
OZEM leans toward sectors like Healthcare. Meanwhile, ASD focuses on Healthcare and Consumer Non-Cyclicals.
What are the top holdings of the OZEM ETF and ASD ETF?
OZEM top holdings include Novo Nordisk A/S, Eli Lilly & Co. and Pfizer Inc.. ASD holds in its top three: Otsuka Holdings Co., Ltd., Lifestance Health Group, Inc. and ACADIA Pharmaceuticals, Inc..
Which ETF is more diversified: OZEM or ASD?
OZEM holds 24 securities with 82.24% of its assets in the top 15. ASD has 37 securities and a top 15 weight of 41.3%.
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Latest news about OZEM & ASD
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