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MEDXvsIHEETF Comparison

ETF 1
MEDX

Horizon Kinetics Medical ETF

This fund is part of
Tomorrow's Treatments
+0.64%
Full MEDX fund page
VS
ETF 2
IHE

iShares U.S. Pharmaceuticals ETF

This fund is part of
US Health Care
-0.51%
Full IHE fund page

Horizon Kinetics Medical ETF (MEDX) belongs to the Tomorrow's Treatments segment. iShares U.S. Pharmaceuticals ETF (IHE) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. MEDX is more expensive with a Total Expense Ratio (TER) of 0.85%, versus 0.38% for IHE. MEDX is up 2.53% year-to-date (YTD) with - in YTD flows. IHE performs better with 4.57% YTD performance, and +$133M in YTD flows. Run a side-by-side ETF comparison of MEDX and IHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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MEDX vs IHE performance and flow charts

Performance

-2.0-1.00.01.02.03.04.0%Feb 10Feb 18Feb 25Mar 4

Cumulative Flows

0 M5 M10 M15 M20 MFeb 10Feb 18Feb 25Mar 4

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Historic performance and flows
Data as of 03/10/2026
1M3MYTD1Y3Y5Y
Perf.
MEDX
IHE
-0.52%-1.43%
+4.39%+7.02%
+2.53%+4.57%
+20.47%+27.21%
+31.16%+64.45%
n/a+63.29%
Flows
MEDX
IHE
-+$14M
-+$159M
-+$133M
-$787K+$252M
-$2M+$364M
-+$397M
Volatility and drawdown
3M1Y3Y5Y
Volatility
MEDX
IHE
+18.47%+15.90%
+20.51%+20.44%
+16.50%+15.94%
n/a+15.80%
Max drawdown
MEDX
IHE
-4.54%-4.49%
-15.78%-14.18%
-23.05%-16.04%
n/a-16.12%
Max drawdown duration
MEDX
IHE
9d9d
163d150d
393d210d
n/a669d
Trading data

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MEDX
IHE
Last sale
3/11/2026 at 1:30 PM
$33.89
$88.40
Previous close
03/10/2026
$34.07
$88.62
Consolidated volume
03/10/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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MEDX
is actively managed and doesn’t replicate an index

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MEDX
IHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/11/2026 at 1:30 PM
Live
Closed
MEDX
IHE
Last price
$33.89
$88.40
1D performance
-0.54%
-0.25%
AuM$19.42 M$1.02 B
E/R0.85%0.38%
Characteristics
MEDX
IHE
Management strategyActivePassive
ProviderHorizon Kinetics LLCiShares
Benchmark-Dow Jones U.S. Select Pharmaceuticals Index
N° of holdings2446
Asset class-Equities
Trailing 12m distribution yield
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Inception dateJanuary 27, 2023May 1, 2006
ESGNoNo
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Exposure

Countries

MEDX
USA
84.84%
Other
15.16%
IHE
USA
90.92%
Other
9.08%

Sectors

MEDX
Health Care
74.67%
Other
25.33%
IHE
Health Care
96.19%
Other
3.81%

Diversification

MEDX

Total weight of top 15 holdings out of 15

81.25%
IHE

Total weight of top 15 holdings out of 15

84.8%

Top 15 holdings

Data as of January 31, 2026
MEDX
LILLY
17.29%
ABBVIE
8.44%
US66987V1098
7.14%
JOHNSON&JOHNSON
5.50%
US0463531089
5.38%
IONIS PHARMACEUTICALS INC
5.14%
BRISTOL-MYERS SQUIBB
4.60%
ALNYLAM PHARMACEUTICALS
4.36%
AMGEN-T
4.06%
ALKERMES
3.93%
MERCK & CO INC
3.61%
PFIZER
3.37%
CRISPR THERAPEUTICS
2.85%
US37733W2044
2.84%
BIOGEN INC
2.74%
IHE
JOHNSON&JOHNSON
23.72%
LILLY
22.21%
MERCK & CO INC
4.78%
BRISTOL-MYERS SQUIBB
4.57%
ZOETIS INC
4.44%
PFIZER
4.36%
ROYALTY PHARMA
4.08%
VIATRIS INC
4.00%
ELANCO ANIMAL HEALTH INC
3.20%
JAZZ PHARMACEUTICALS
2.65%
AXSOME THERA CMN STK
2.09%
CRINETICS PHARMACEUTICALS
1.41%
US45579U1097
1.15%
CORCEPT THERAPEUTICS
1.11%
LIGAND PHARMACEUTICALS
1.02%
Frequently asked questions about MEDX and IHE

How have the MEDX and IHE ETFs performed in 2026?

As of March 10, 2026, MEDX is up 2.53% year-to-date (YTD), while IHE has returned 4.57%. That puts IHE better performer ahead so far this year.

Which ETF is attracting more investor money: MEDX or IHE?

Year-to-date, the MEDX ETF saw - in flows, compared to +$133M for IHE.

Which ETF is more volatile: MEDX or IHE?

Over the past year, MEDX had a volatility of 20.51%, while IHE experienced 20.44%.

Which ETF is bigger: MEDX or IHE?

As of March 10, 2026, MEDX holds $19.42 M in assets under management (AUM), while IHE manages $1.02 B.

What sectors do the MEDX and IHE ETFs invest in?

MEDX leans toward sectors like Health Care. Meanwhile, IHE focuses on Health Care.

What are the top holdings of the MEDX ETF and IHE ETF?

MEDX top holdings include LILLY, ABBVIE and US66987V1098. IHE holds in its top three: JOHNSON&JOHNSON, LILLY and MERCK & CO INC.

Which ETF is more diversified: MEDX or IHE?

MEDX holds 29 securities with 81.25% of its assets in the top 15. IHE has 56 securities and a top 15 weight of 84.8%.

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