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LFSCvsXPHETF Comparison

ETF 1
LFSC

F/m Emerald Life Sciences Innovation ETF

This fund is part of
Life Sciences
+0.82%
Full LFSC fund page
VS
ETF 2
XPH

SPDR S&P Pharmaceuticals ETF

This fund is part of
US Health Care
-0.51%
Full XPH fund page

F/m Emerald Life Sciences Innovation ETF (LFSC) belongs to the Life Sciences segment. SPDR S&P Pharmaceuticals ETF (XPH) is part of the US Health Care segment. LFSC's top 3 sector exposures are Health Care and Sovereign. In contrast, XPH's top sector exposures are Health Care  LFSC is more expensive with a Total Expense Ratio (TER) of 0.79%, versus 0.35% for XPH. LFSC is down -3.7% year-to-date (YTD) with +$7M in YTD flows. XPH performs better with -0.63% YTD performance, and +$93M in YTD flows. Run a side-by-side ETF comparison of LFSC and XPH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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LFSC vs XPH performance and flow charts

Performance

-4.0-2.00.02.0%Feb 10Feb 18Feb 25Mar 4

Cumulative Flows

0 M5 M10 M15 MFeb 10Feb 18Feb 25Mar 4

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Historic performance and flows
Data as of 03/10/2026
1M3MYTD1Y3Y5Y
Perf.
LFSC
XPH
-2.09%-3.39%
-10.37%-1.18%
-3.70%-0.63%
+60.97%+28.38%
n/a+46.04%
n/a+12.03%
Flows
LFSC
XPH
+$7M+$17M
+$8M+$95M
+$7M+$93M
+$18M+$117M
-+$58M
-+$41M
Volatility and drawdown
3M1Y3Y5Y
Volatility
LFSC
XPH
+22.01%+20.32%
+28.67%+23.10%
n/a+19.03%
n/a+20.28%
Max drawdown
LFSC
XPH
-13.02%-5.97%
-19.03%-17.10%
n/a-23.45%
n/a-33.10%
Max drawdown duration
LFSC
XPH
90d13d
70d140d
n/a322d
n/a1706d
Trading data

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LFSC
XPH
Last sale
3/11/2026 at 1:30 PM
$35.01
$55.49
Previous close
03/10/2026
$35.21
$55.67
Consolidated volume
03/10/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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LFSC
is actively managed and doesn’t replicate an index

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LFSC
XPH
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/11/2026 at 1:30 PM
Live
Closed
LFSC
XPH
Last price
$35.01
$55.49
1D performance
-0.57%
-0.32%
AuM$95.79 M$320.49 M
E/R0.79%0.35%
Characteristics
LFSC
XPH
Management strategyActivePassive
ProviderEmerald GroupSPDR
Benchmark-S&P Pharmaceuticals Select Industry Index
N° of holdings3449
Asset class-Equities
Trailing 12m distribution yield
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Inception dateOctober 31, 2024June 19, 2006
ESGNoNo
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Exposure

Countries

LFSC
USA
88.44%
Other
11.56%
XPH
USA
85.59%
Other
14.41%

Sectors

LFSC
Health Care
86.26%
Other
13.74%
XPH
Health Care
81.97%
Other
18.03%
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Diversification

LFSC

Total weight of top 15 holdings out of 15

68.94%
XPH

Total weight of top 15 holdings out of 15

32.4%

Top 15 holdings

Data as of January 31, 2026
LFSC
COGENT BIOSCIENCES
9.06%
LIVANOVA
6.76%
GUARDANT HEALTH INC
5.62%
MIRUM PHARMACEUTICALS INC
5.37%
TRANSMEDICS GROUP
5.18%
WAVE LFE SCIEN
4.81%
TRAVERE THERAPEUTICS INC
4.77%
BRIDGEBIO PHARMA
3.92%
SAVARA INC
3.82%
ICU MEDICAL
3.60%
KALVISTA PHARMACEUTICALS INC
3.59%
UTD THERAPEUT
3.56%
US00773J2024
3.44%
MADRIGAL PHARMACEUTICALS INC
2.86%
ACADIA PHARMACEUTICALS
2.58%
XPH
LIQUIDIA CORPORATION
2.45%
US55287L1017
2.41%
AXSOME THERA CMN STK
2.33%
ORGANON & CO
2.25%
EDGEWISE THERAPEUTICS
2.24%
ELANCO ANIMAL HEALTH INC
2.13%
MERCK & CO INC
2.13%
VIATRIS INC
2.13%
AMNEAL PHARMACEUTICALS INC
2.12%
JOHNSON&JOHNSON
2.08%
ROYALTY PHARMA
2.06%
AMYLYX PHARMACEUTICALS
2.04%
BRISTOL-MYERS SQUIBB
2.03%
XERIS BIOPHARMA HOLDINGS INC
2.00%
ZOETIS INC
2.00%
Frequently asked questions about LFSC and XPH

How have the LFSC and XPH ETFs performed in 2026?

As of March 10, 2026, LFSC is down -3.7% year-to-date (YTD), while XPH has lost -0.63%. That puts XPH better performer ahead so far this year.

Which ETF is attracting more investor money: LFSC or XPH?

Year-to-date, the LFSC ETF saw +$7M in flows, compared to +$93M for XPH.

Which ETF is more volatile: LFSC or XPH?

Over the past year, LFSC had a volatility of 28.67%, while XPH experienced 23.1%.

Which ETF is bigger: LFSC or XPH?

As of March 10, 2026, LFSC holds $95.79 M in assets under management (AUM), while XPH manages $320.49 M.

What sectors do the LFSC and XPH ETFs invest in?

LFSC leans toward sectors like Health Care. Meanwhile, XPH focuses on Health Care.

What are the top holdings of the LFSC ETF and XPH ETF?

LFSC top holdings include COGENT BIOSCIENCES, LIVANOVA and GUARDANT HEALTH INC. XPH holds in its top three: LIQUIDIA CORPORATION, US55287L1017 and AXSOME THERA CMN STK.

Which ETF is more diversified: LFSC or XPH?

LFSC holds 42 securities with 68.94% of its assets in the top 15. XPH has 57 securities and a top 15 weight of 32.4%.

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