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IXJvsXLVIETF Comparison

ETF 1
IXJ

iShares Global Healthcare ETF

This fund is part of
Global Large Cap
-1.52%
Full IXJ fund page
VS
ETF 2
XLVI

The Health Care Select Sector SPDR Premium Income Fund

This fund is part of
Options Strategies
-1.02%
Full XLVI fund page

iShares Global Healthcare ETF (IXJ) belongs to the Global Large Cap segment. The Health Care Select Sector SPDR Premium Income Fund (XLVI) is part of the Options Strategies segment. IXJ's top 3 sector exposures are Health Care, Consumer Discretionary and Consumer Staples. In contrast, XLVI's top sector exposures are Health Care,  IXJ is more expensive with a Total Expense Ratio (TER) of 0.4%, versus 0.35% for XLVI. IXJ is down -2.64% year-to-date (YTD) with -$688M in YTD flows. XLVI performs better with -1.41% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of IXJ and XLVI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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IXJ vs XLVI performance and flow charts

Performance

-6.0-4.0-2.00.02.0%Feb 12Feb 20Feb 27Mar 6

Cumulative Flows

-600,000,000-500,000,000-400,000,000-300,000,000-200,000,000-100,000,0000Feb 12Feb 20Feb 27Mar 6

Get all the metrics on this page, and more, through a reliable ETF data feed

Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 03/12/2026
1M3MYTD1Y3Y5Y
Perf.
IXJ
XLVI
-5.34%-2.60%
-1.68%-0.20%
-2.64%-1.41%
+5.89%n/a
+24.23%n/a
+34.09%n/a
Flows
IXJ
XLVI
-$599M+$788K
-$664M+$3M
-$688M+$2M
-$427M-
-$883M-
+$219M-
Volatility and drawdown
3M1Y3Y5Y
Volatility
IXJ
XLVI
+13.35%+10.72%
+16.82%n/a
+13.09%n/a
+13.81%n/a
Max drawdown
IXJ
XLVI
-6.98%-4.68%
-10.89%n/a
-18.04%n/a
-18.04%n/a
Max drawdown duration
IXJ
XLVI
11d11d
196dn/a
490dn/a
490dn/a
Trading data

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IXJ
XLVI
Last sale
3/13/2026 at 1:30 PM
$94.30
$25.46
Previous close
03/12/2026
$94.78
$25.54
Consolidated volume
03/12/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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XLVI
is actively managed and doesn’t replicate an index

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IXJ
XLVI
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/13/2026 at 1:30 PM
Live
Closed
IXJ
XLVI
Last price
$94.30
$25.46
1D performance
-0.51%
-0.32%
AuM$3.73 B$13.01 M
E/R0.4%0.35%
Characteristics
IXJ
XLVI
Management strategyPassiveActive
ProvideriSharesSPDR
BenchmarkS&P Global 1200 Healthcare Index-
N° of holdings10557
Asset classEquities-
Trailing 12m distribution yield
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Inception dateNovember 13, 2001July 30, 2025
ESGNoNo
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Exposure

Countries

IXJ
USA
67.85%
Switzerland
10.23%
Other
21.92%
XLVI
USA
96.37%
Other
3.63%

Sectors

IXJ
Health Care
93.2%
Other
6.8%
XLVI
Health Care
97.65%
Other
2.35%
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Diversification

IXJ

Total weight of top 15 holdings out of 15

55.7%
XLVI

Total weight of top 15 holdings out of 15

69.69%

Top 15 holdings

Data as of January 31, 2026
IXJ
LILLY
10.17%
JOHNSON&JOHNSON
6.85%
ABBVIE
4.87%
ROCHE
3.97%
ASTRAZENECA
3.59%
NOVARTIS
3.54%
MERCK & CO INC
3.36%
UNITEDHEALTH GRP
3.31%
THERMO FISHER SCIENTIFIC
2.79%
DK0062498333
2.36%
AMGEN-T
2.31%
ABBOTT LABS
2.30%
INTUITIVE SURGICAL
2.25%
GILEAD SCIENCES
2.16%
PFIZER
1.86%
XLVI
LILLY
14.60%
JOHNSON&JOHNSON
9.71%
ABBVIE
6.99%
MERCK & CO INC
4.85%
UNITEDHEALTH GRP
4.61%
THERMO FISHER SCIENTIFIC
3.85%
ABBOTT LABS
3.37%
AMGEN-T
3.26%
INTUITIVE SURGICAL
3.17%
GILEAD SCIENCES
3.12%
PFIZER
2.66%
BOSTON SCIENTIFIC
2.46%
DANAHER
2.44%
MEDTRONIC PLC
2.34%
STRYKER
2.25%
Frequently asked questions about IXJ and XLVI

How have the IXJ and XLVI ETFs performed in 2026?

As of March 12, 2026, IXJ is down -2.64% year-to-date (YTD), while XLVI has lost -1.41%. That puts XLVI better performer ahead so far this year.

Which ETF is attracting more investor money: IXJ or XLVI?

Year-to-date, the IXJ ETF saw -$688M in flows, compared to +$2M for XLVI.

Which ETF is bigger: IXJ or XLVI?

As of March 12, 2026, IXJ holds $3.73 B in assets under management (AUM), while XLVI manages $13.01 M.

What sectors do the IXJ and XLVI ETFs invest in?

IXJ leans toward sectors like Health Care. Meanwhile, XLVI focuses on Health Care.

What are the top holdings of the IXJ ETF and XLVI ETF?

IXJ top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. XLVI holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.

Which ETF is more diversified: IXJ or XLVI?

IXJ holds 115 securities with 55.7% of its assets in the top 15. XLVI has 60 securities and a top 15 weight of 69.69%.

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