IHEvsXLVIETF Comparison
VS
ETF 2
XLVI
State Street Health Care Select Sector SPDR Premium Income Fund
This fund is part of
Options Strategies
-0.18%
iShares U.S. Pharmaceuticals ETF (IHE) belongs to the US Health Care segment. State Street Health Care Select Sector SPDR Premium Income Fund (XLVI) is part of the Options Strategies segment. Both ETFs have the same top 3 sector exposures: and Health Care. IHE is more expensive with a Total Expense Ratio (TER) of 0.38%, versus 0.35% for XLVI. IHE is up 10.98% year-to-date (YTD) with -$7M in YTD flows. XLVI performs worse with 2.13% YTD performance, and +$4M in YTD flows. Run a side-by-side ETF comparison of IHE and XLVI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IHE vs XLVI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/09/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IHE XLVI | +7.64%+6.44% | +6.21%+1.06% | +10.98%+2.13% | +43.87%n/a | +68.58%n/a | +64.51%n/a |
| Flows | IHE XLVI | +$100K+$2M | -$145M+$2M | -$7M+$4M | +$126M- | +$223M- | +$256M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IHE XLVI | +19.73%+13.59% | +17.31%n/a | +16.50%n/a | +16.23%n/a |
| Max drawdown | IHE XLVI | -5.19%-6.06% | -8.48%n/a | -16.04%n/a | -16.12%n/a |
| Max drawdown duration | IHE XLVI | 37d86d | 81dn/a | 210dn/a | 669dn/a |
Trading data
IHE | XLVI | |
Last sale 6/10/2026 at 1:30 PM | $93.34 | $25.50 |
| Previous close 06/09/2026 | $93.79 | $25.60 |
| Consolidated volume 06/09/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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XLVI
is actively managed and doesn’t replicate an indexIHE | XLVI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/10/2026 at 1:30 PM
Live
Closed
IHE | XLVI | |
|---|---|---|
| Last price | $93.34 | $25.50 |
| 1D performance | -0.48% | -0.38% |
| AuM | $933.05 M | $14.84 M |
| E/R | 0.38% | 0.35% |
Characteristics
IHE | XLVI | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | iShares | State Street Investment Management |
| Benchmark | Dow Jones U.S. Select Pharmaceuticals Index | - |
| N° of holdings | 45 | 55 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | May 1, 2006 | July 30, 2025 |
| ESG | No | No |
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Exposure
Countries
IHE
USA
90.2%
Other
9.8%
XLVI
USA
96.67%
Other
3.33%
Sectors
IHE
Health Care
95.09%
Other
4.91%
XLVI
Health Care
97.69%
Other
2.31%
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Diversification
IHE
Total weight of top 15 holdings out of 15
83.6%
XLVI
Total weight of top 15 holdings out of 15
70.39%
Top 15 holdings
Data as of April 30, 2026
IHE
JOHNSON&JOHNSON
21.40%
LILLY
21.14%
ROYALTY PHARMA
4.85%
VIATRIS INC
4.75%
BRISTOL-MYERS SQUIBB
4.57%
PFIZER
4.42%
ZOETIS INC
4.34%
MERCK & CO INC
4.25%
JAZZ PHARMACEUTICALS
3.40%
ELANCO ANIMAL HEALTH INC
3.07%
AXSOME THERA CMN STK
2.43%
US45579U1097
1.27%
TERNS PHARMACEUTICALS
1.26%
LIGAND PHARMACEUTICALS
1.25%
CORCEPT THERAPEUTICS
1.20%
XLVI
LILLY
13.98%
JOHNSON&JOHNSON
10.46%
ABBVIE
7.05%
UNITEDHEALTH GRP
6.34%
MERCK & CO INC
5.12%
AMGEN-T
3.52%
THERMO FISHER SCIENTIFIC
3.40%
INTUITIVE SURGICAL
3.07%
GILEAD SCIENCES
3.06%
ABBOTT LABS
2.98%
PFIZER
2.87%
BRISTOL-MYERS SQUIBB
2.33%
DANAHER
2.13%
VERTEX PHARMACEUTICALS
2.05%
STRYKER
2.05%
Frequently asked questions about IHE and XLVI
How have the IHE and XLVI ETFs performed in 2026?
As of June 9, 2026, IHE is up 10.98% year-to-date (YTD), while XLVI has returned 2.13%. That puts IHE better performer ahead so far this year.
Which ETF is attracting more investor money: IHE or XLVI?
Year-to-date, the IHE ETF saw -$7M in flows, compared to +$4M for XLVI.
Which ETF is bigger: IHE or XLVI?
As of June 9, 2026, IHE holds $933.05 M in assets under management (AUM), while XLVI manages $14.84 M.
What sectors do the IHE and XLVI ETFs invest in?
IHE leans toward sectors like Health Care. Meanwhile, XLVI focuses on Health Care.
What are the top holdings of the IHE ETF and XLVI ETF?
IHE top holdings include JOHNSON&JOHNSON, LILLY and ROYALTY PHARMA. XLVI holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.
Which ETF is more diversified: IHE or XLVI?
IHE holds 57 securities with 83.6% of its assets in the top 15. XLVI has 58 securities and a top 15 weight of 70.39%.
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Latest news about IHE & XLVI
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