CANCvsBBCETF Comparison
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Tema Oncology ETF (CANC) and Virtus LifeSci Biotech Clinical Trials ETF (BBC) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Health Care. CANC is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.79% for BBC. CANC is up 8.22% year-to-date (YTD) with +$52M in YTD flows. BBC performs better with 11.08% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of CANC and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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CANC vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/12/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | CANC BBC | -0.48%-3.51% | +3.95%+3.66% | +8.22%+11.08% | +45.49%+115.50% | n/a+72.15% | n/a-14.96% |
| Flows | CANC BBC | +$5M-$4M | +$11M+$3M | +$52M+$5M | +$69M+$13M | -+$15M | -+$6M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | CANC BBC | +24.37%+39.19% | +22.62%+35.34% | n/a+36.73% | n/a+39.48% |
| Max drawdown | CANC BBC | -9.20%-14.64% | -9.20%-14.64% | n/a-54.25% | n/a-72.44% |
| Max drawdown duration | CANC BBC | 54d53d | 54d53d | n/a340d | n/a1824d |
Trading data
CANC | BBC | |
Last sale 6/12/2026 at 1:30 PM | $37.48 | $43.03 |
| Previous close 06/12/2026 | $37.26 | $42.22 |
| Consolidated volume 06/12/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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CANC
is actively managed and doesn’t replicate an indexCANC | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/12/2026 at 1:30 PM
Live
Closed
CANC | BBC | |
|---|---|---|
| Last price | $37.48 | $43.03 |
| 1D performance | +0.60% | +1.92% |
| AuM | $178.42 M | $40.82 M |
| E/R | 0.99% | 0.79% |
Characteristics
CANC | BBC | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Tema | VIRTUS Investment Partners |
| Benchmark | - | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 42 | 79 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | August 15, 2023 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
CANC
USA
87.11%
Other
12.89%
BBC
USA
86.45%
Other
13.55%
Sectors
CANC
Health Care
76.64%
Other
23.36%
BBC
Health Care
61.08%
Other
38.92%
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Diversification
CANC
Total weight of top 15 holdings out of 15
54.47%
BBC
Total weight of top 15 holdings out of 15
22.36%
Top 15 holdings
Data as of April 30, 2026
CANC
REVOLUTION MEDICINES INC
6.51%
IMMUNOME
4.24%
US7711951043
4.15%
COGENT BIOSCIENCES
4.07%
NOVARTIS
4.00%
LILLY
3.81%
ASTRAZENECA
3.62%
BRISTOL-MYERS SQUIBB
3.36%
MERCK & CO INC
3.34%
CELCUITY INC
3.31%
NUVALENT
3.20%
BRIDGEBIO PHARMA
2.84%
US3723032062
2.82%
LEGEND BIOTECH
2.63%
US98887Q1040
2.57%
BBC
TANGO THERAPEUTICS INC
2.09%
US29337E1029
1.97%
US6876041087
1.87%
US0223071020
1.59%
US00773J2024
1.58%
US2528281080
1.53%
CORVUS PHARMACEUTICALS INC
1.41%
RELAY THERAPEUTICS
1.38%
KODIAK SCIENCES INC
1.37%
REZOLUTE INC
1.36%
US0080642061
1.33%
REVOLUTION MEDICINES INC
1.23%
US45720N1037
1.22%
TYRA BIOSCIENCES
1.21%
US1569441009
1.21%
Frequently asked questions about CANC and BBC
How have the CANC and BBC ETFs performed in 2026?
As of June 12, 2026, CANC is up 8.22% year-to-date (YTD), while BBC has returned 11.08%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: CANC or BBC?
Year-to-date, the CANC ETF saw +$52M in flows, compared to +$5M for BBC.
Which ETF is more volatile: CANC or BBC?
Over the past year, CANC had a volatility of 22.62%, while BBC experienced 35.34%.
Which ETF is bigger: CANC or BBC?
As of June 12, 2026, CANC holds $178.42 M in assets under management (AUM), while BBC manages $40.82 M.
What sectors do the CANC and BBC ETFs invest in?
CANC leans toward sectors like Health Care. Meanwhile, BBC focuses on Health Care.
What are the top holdings of the CANC ETF and BBC ETF?
CANC top holdings include REVOLUTION MEDICINES INC, IMMUNOME and US7711951043. BBC holds in its top three: TANGO THERAPEUTICS INC, US29337E1029 and US6876041087.
Which ETF is more diversified: CANC or BBC?
CANC holds 53 securities with 54.47% of its assets in the top 15. BBC has 119 securities and a top 15 weight of 22.36%.
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