CANCvsBBCETF Comparison
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Tema Oncology ETF (CANC) and Virtus LifeSci Biotech Clinical Trials ETF (BBC) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Health Care. CANC is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.79% for BBC. CANC is up 10.62% year-to-date (YTD) with +$50M in YTD flows. BBC performs better with 19.79% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of CANC and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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CANC vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | CANC BBC | +10.08%+16.04% | +5.34%+8.50% | +10.62%+19.79% | +55.67%+156.88% | n/a+102.94% | n/a-4.45% |
| Flows | CANC BBC | +$5M-$4M | +$29M-$4M | +$50M-$2M | +$70M+$7M | -+$8M | --$6M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | CANC BBC | +23.62%+35.84% | +23.46%+36.10% | n/a+36.28% | n/a+39.27% |
| Max drawdown | CANC BBC | -7.99%-10.55% | -10.53%-13.01% | n/a-54.25% | n/a-72.57% |
| Max drawdown duration | CANC BBC | 43d28d | 32d31d | n/a340d | n/a1821d |
Trading data
CANC | BBC | |
Last sale 4/27/2026 at 1:30 PM | $37.78 | $45.58 |
| Previous close 04/24/2026 | $38.36 | $45.95 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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CANC
is actively managed and doesn’t replicate an indexCANC | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/27/2026 at 1:30 PM
Live
Closed
CANC | BBC | |
|---|---|---|
| Last price | $37.78 | $45.58 |
| 1D performance | -1.52% | -0.80% |
| AuM | $179.70 M | $37.07 M |
| E/R | 0.99% | 0.79% |
Characteristics
CANC | BBC | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Tema | VIRTUS Investment Partners |
| Benchmark | - | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 44 | 80 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | August 15, 2023 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
CANC
USA
85.51%
Other
14.49%
BBC
USA
86.93%
Other
13.07%
Sectors
CANC
Health Care
78.17%
Other
21.83%
BBC
Health Care
63.83%
Other
36.17%
Diversification
CANC
Total weight of top 15 holdings out of 15
56.1%
BBC
Total weight of top 15 holdings out of 15
21.19%
Top 15 holdings
Data as of March 31, 2026
CANC
REVOLUTION MEDICINES INC
4.95%
ASTRAZENECA
4.60%
NOVARTIS
4.45%
US7711951043
4.26%
LILLY
4.20%
BRIDGEBIO PHARMA
3.94%
COGENT BIOSCIENCES
3.88%
BRISTOL-MYERS SQUIBB
3.74%
MERCK & CO INC
3.62%
IMMUNOME
3.30%
JOHNSON&JOHNSON
3.23%
NUVALENT
3.20%
CELCUITY INC
3.07%
US3723032062
2.95%
ABBVIE
2.71%
BBC
US29337E1029
1.88%
US0223071020
1.84%
TANGO THERAPEUTICS INC
1.71%
US2528281080
1.57%
REZOLUTE INC
1.45%
TYRA BIOSCIENCES
1.35%
CORVUS PHARMACEUTICALS INC
1.35%
KODIAK SCIENCES INC
1.34%
US1569441009
1.31%
ALLOGENE THERAPEUTICS INC
1.28%
ARCELLX
1.28%
US8789721086
1.25%
US6876041087
1.21%
INTELLIA THERAPEUTICS INC
1.18%
ANAPTYSBIO INC
1.16%
Frequently asked questions about CANC and BBC
How have the CANC and BBC ETFs performed in 2026?
As of April 24, 2026, CANC is up 10.62% year-to-date (YTD), while BBC has returned 19.79%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: CANC or BBC?
Year-to-date, the CANC ETF saw +$50M in flows, compared to -$2M for BBC.
Which ETF is more volatile: CANC or BBC?
Over the past year, CANC had a volatility of 23.46%, while BBC experienced 36.1%.
Which ETF is bigger: CANC or BBC?
As of April 24, 2026, CANC holds $179.70 M in assets under management (AUM), while BBC manages $37.07 M.
What sectors do the CANC and BBC ETFs invest in?
CANC leans toward sectors like Health Care. Meanwhile, BBC focuses on Health Care.
What are the top holdings of the CANC ETF and BBC ETF?
CANC top holdings include REVOLUTION MEDICINES INC, ASTRAZENECA and NOVARTIS. BBC holds in its top three: US29337E1029, US0223071020 and TANGO THERAPEUTICS INC.
Which ETF is more diversified: CANC or BBC?
CANC holds 54 securities with 56.1% of its assets in the top 15. BBC has 120 securities and a top 15 weight of 21.19%.
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