BBPvsHRTSETF Comparison
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Virtus LifeSci Biotech Products ETF (BBP) and Tema GLP-1, Obesity & Cardiometabolic ETF (HRTS) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Healthcare. BBP is less expensive with a Total Expense Ratio (TER) of 0.34%, versus 0.99% for HRTS. BBP is up 21.54% year-to-date (YTD) with +$40M in YTD flows. HRTS performs worse with 4.07% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of BBP and HRTS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBP vs HRTS performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBP HRTS | +0.94%+0.32% | +15.67%+11.00% | +21.54%+4.07% | +56.59%+28.35% | +81.31%n/a | +94.15%n/a |
| Flows | BBP HRTS | +$10M- | +$28M-$70K | +$40M-$2M | +$52M-$6M | +$55M- | +$48M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBP HRTS | +26.32%+17.82% | +24.02%+16.07% | +24.33%n/a | +26.47%n/a |
| Max drawdown | BBP HRTS | -7.49%-4.69% | -9.59%-10.68% | -25.54%n/a | -37.61%n/a |
| Max drawdown duration | BBP HRTS | 44d20d | 48d170d | 292dn/a | 586dn/a |
Trading data
BBP | HRTS | |
Last sale 7/28/2026 at 1:30 PM | $97.69 | $37.39 |
| Previous close 07/27/2026 | $97.26 | $36.81 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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HRTS
is actively managed and doesn’t replicate an indexBBP | HRTS | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/28/2026 at 1:30 PM
Live
Closed
BBP | HRTS | |
|---|---|---|
| Last price | $97.69 | $37.39 |
| 1D performance | +0.45% | +1.59% |
| AuM | $96.94 M | $54.78 M |
| E/R | 0.34% | 0.99% |
Characteristics
BBP | HRTS | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | VIRTUS Investment Partners | Tema |
| Benchmark | LifeSci Biotechnology Products Index | - |
| N° of holdings | 66 | 43 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | November 21, 2023 |
| ESG | No | No |
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Exposure
Countries
BBP
USA
89.11%
Other
10.89%
HRTS
USA
76.55%
Switzerland
7.26%
Other
16.19%
Sectors
BBP
Healthcare
89.47%
Other
10.53%
HRTS
Healthcare
99.57%
Other
0.43%
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Diversification
BBP
Total weight of top 15 holdings out of 15
87.15%
HRTS
Total weight of top 15 holdings out of 15
64.29%
Top 15 holdings
Data as of June 30, 2026
BBP
Verastem, Inc.
44.58%
Legend Biotech Corp.
41.98%
Agios Pharmaceuticals, Inc.
0.05%
BioCryst Pharmaceuticals, Inc.
0.05%
BioMarin Pharmaceutical, Inc.
0.05%
Rigel Pharmaceuticals, Inc.
0.05%
Crinetics Pharmaceuticals, Inc.
0.05%
Madrigal Pharmaceuticals, Inc.
0.05%
BioNTech SE
0.05%
Iovance Biotherapeutics, Inc.
0.05%
Rhythm Pharmaceuticals, Inc.
0.05%
Alnylam Pharmaceuticals, Inc.
0.05%
Incyte Corp.
0.05%
Sarepta Therapeutics, Inc.
0.05%
Omeros Corp.
0.05%
HRTS
Eli Lilly & Co.
11.91%
UnitedHealth Group, Inc.
5.58%
Novo Nordisk A/S
5.25%
Merck & Co., Inc.
4.11%
Roche Holding AG
3.96%
Thermo Fisher Scientific, Inc.
3.91%
AstraZeneca PLC
3.85%
Johnson & Johnson
3.84%
Revolution Medicines, Inc.
3.64%
Cytokinetics, Inc.
3.40%
Novartis AG
3.30%
Gilead Sciences, Inc.
3.09%
Vertex Pharmaceuticals, Inc.
3.04%
Abbott Laboratories
2.71%
Danaher Corp.
2.70%
Frequently asked questions about BBP and HRTS
How have the BBP and HRTS ETFs performed in 2026?
As of July 27, 2026, BBP is up 21.54% year-to-date (YTD), while HRTS has returned 4.07%. That puts BBP better performer ahead so far this year.
Which ETF is attracting more investor money: BBP or HRTS?
Year-to-date, the BBP ETF saw +$40M in flows, compared to -$2M for HRTS.
Which ETF is more volatile: BBP or HRTS?
Over the past year, BBP had a volatility of 24.02%, while HRTS experienced 16.07%.
Which ETF is bigger: BBP or HRTS?
As of July 27, 2026, BBP holds $96.94 M in assets under management (AUM), while HRTS manages $54.78 M.
What sectors do the BBP and HRTS ETFs invest in?
BBP leans toward sectors like Healthcare. Meanwhile, HRTS focuses on Healthcare.
What are the top holdings of the BBP ETF and HRTS ETF?
BBP top holdings include Verastem, Inc., Legend Biotech Corp. and Agios Pharmaceuticals, Inc.. HRTS holds in its top three: Eli Lilly & Co., UnitedHealth Group, Inc. and Novo Nordisk A/S.
Which ETF is more diversified: BBP or HRTS?
BBP holds 66 securities with 87.15% of its assets in the top 15. HRTS has 43 securities and a top 15 weight of 64.29%.
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Latest news about BBP & HRTS
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