BBCvsXHSETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. State Street SPDR S&P Health Care Services ETF (XHS) is part of the US Health Care segment. BBC's top 1 sector exposures are Healthcare. In contrast, XHS's top sector exposures are Healthcare, Consumer Non-Cyclicals and Business Services. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.35% for XHS. BBC is up 13.68% year-to-date (YTD) with +$2M in YTD flows. XHS performs better with 33.45% YTD performance, and +$106M in YTD flows. Run a side-by-side ETF comparison of BBC and XHS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs XHS performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC XHS | -4.54%+6.20% | -10.21%+4.88% | +13.68%+33.45% | +39.31%+35.84% | +159.89%+83.23% | +0.98%+36.82% |
| Flows | BBC XHS | -$2M-$12M | -$2M+$6M | +$2M+$106M | +$10M+$109M | +$14M+$80M | +$6M+$39M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC XHS | +37.13%+16.86% | +37.04%+17.58% | +37.66%+18.30% | +40.00%+21.34% |
| Max drawdown | BBC XHS | -29.70%-5.21% | -29.70%-11.97% | -54.25%-14.46% | -70.04%-29.93% |
| Max drawdown duration | BBC XHS | 70d30d | 70d121d | 340d250d | 1625d1477d |
Trading data
BBC | XHS | |
Last sale 10/28/2026 at 7:57 PM | $43.95 | $143.50 |
| Previous close 10/28/2026 | $42.87 | $142.73 |
| Consolidated volume 10/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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BBC | XHS | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/28/2026 at 7:57 PM
Live
Closed
BBC | XHS | |
|---|---|---|
| Last price | $43.95 | $143.50 |
| 1D performance | +2.51% | +0.54% |
| AuM | $39.58 M | $226.62 M |
| E/R | 0.65% | 0.35% |
Characteristics
BBC | XHS | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | State Street Investment Management |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S&P Health Care Services Select Industry Index |
| N° of holdings | 127 | 59 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | September 28, 2011 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
87.24%
Other
12.76%
XHS
USA
99.94%
Other
0.06%
Sectors
BBC
Healthcare
96.27%
Other
3.73%
XHS
Healthcare
95.16%
Other
4.84%
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Diversification
BBC
Total weight of top 15 holdings out of 15
17.14%
XHS
Total weight of top 15 holdings out of 15
33.1%
Top 15 holdings
Data as of August 31, 2026
BBC
Amylyx Pharmaceuticals, Inc.
1.50%
First Tracks Biotherapeutics, Inc.
1.48%
AbCellera Biologics, Inc.
1.38%
Xencor, Inc.
1.36%
Monopar Therapeutics, Inc.
1.12%
MBX Biosciences, Inc.
1.11%
uniQure NV
1.09%
Replimune Group, Inc.
1.06%
4D Molecular Therapeutics, Inc.
1.04%
SELLAS Life Sciences Group, Inc.
1.04%
Alto Neuroscience, Inc.
1.00%
LB Pharmaceuticals, Inc.
1.00%
Oric Pharmaceuticals, Inc.
0.99%
Zenas BioPharma, Inc.
0.98%
Cullinan Therapeutics, Inc.
0.98%
XHS
Tenet Healthcare Corp.
2.65%
NeoGenomics, Inc.
2.60%
Lifestance Health Group, Inc.
2.58%
GeneDx Holdings Corp.
2.56%
Hinge Health, Inc.
2.45%
RadNet, Inc.
2.14%
Concentra Group Holdings Parent, Inc.
2.08%
Aveanna Healthcare Holdings, Inc.
2.07%
Labcorp Holdings, Inc.
2.03%
U.S. Physical Therapy, Inc.
2.03%
PACS Group, Inc.
2.02%
Addus HomeCare Corp.
2.02%
Guardant Health, Inc.
1.99%
Chemed Corp.
1.96%
Quest Diagnostics, Inc.
1.93%
Frequently asked questions about BBC and XHS
How have the BBC and XHS ETFs performed in 2026?
As of October 28, 2026, BBC is up 13.68% year-to-date (YTD), while XHS has returned 33.45%. That puts XHS better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or XHS?
Year-to-date, the BBC ETF saw +$2M in flows, compared to +$106M for XHS.
Which ETF is more volatile: BBC or XHS?
Over the past year, BBC had a volatility of 37.04%, while XHS experienced 17.58%.
Which ETF is bigger: BBC or XHS?
As of October 28, 2026, BBC holds $39.58 M in assets under management (AUM), while XHS manages $226.62 M.
What sectors do the BBC and XHS ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, XHS focuses on Healthcare.
What are the top holdings of the BBC ETF and XHS ETF?
BBC top holdings include Amylyx Pharmaceuticals, Inc., First Tracks Biotherapeutics, Inc. and AbCellera Biologics, Inc.. XHS holds in its top three: Tenet Healthcare Corp., NeoGenomics, Inc. and Lifestance Health Group, Inc..
Which ETF is more diversified: BBC or XHS?
BBC holds 127 securities with 17.14% of its assets in the top 15. XHS has 59 securities and a top 15 weight of 33.1%.
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Latest news about BBC & XHS
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