BBCvsXHEETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. State Street SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. BBC's top 1 sector exposures are Healthcare. In contrast, XHE's top sector exposures are Healthcare and Finance. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.35% for XHE. BBC is up 27.77% year-to-date (YTD) with +$5M in YTD flows. XHE performs worse with 2.14% YTD performance, and +$11M in YTD flows. Run a side-by-side ETF comparison of BBC and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs XHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC XHE | -5.78%-5.10% | +17.22%+9.79% | +27.77%+2.14% | +102.82%+9.32% | +137.50%+7.53% | +6.45%-30.21% |
| Flows | BBC XHE | -+$3M | +$83K+$12M | +$5M+$11M | +$12M-$245K | +$16M-$266M | +$8M-$382M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC XHE | +33.39%+24.14% | +36.22%+22.69% | +37.22%+22.22% | +39.64%+24.84% |
| Max drawdown | BBC XHE | -11.65%-7.53% | -14.64%-18.20% | -54.25%-24.35% | -70.43%-49.37% |
| Max drawdown duration | BBC XHE | 23d23d | 60d207d | 340d565d | 1666d1773d |
Trading data
BBC | XHE | |
Last sale 9/14/2026 at 1:30 PM | $49.94 | $91.43 |
| Previous close 09/11/2026 | $49.39 | $90.01 |
| Consolidated volume 09/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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BBC | XHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 9/14/2026 at 1:30 PM
Live
Closed
BBC | XHE | |
|---|---|---|
| Last price | $49.94 | $91.43 |
| 1D performance | +1.12% | +1.58% |
| AuM | $46.95 M | $168.78 M |
| E/R | 0.65% | 0.35% |
Characteristics
BBC | XHE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | State Street Investment Management |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S&P Health Care Equipment Select Industry Index |
| N° of holdings | 127 | 66 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | January 26, 2011 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
86.49%
Other
13.51%
XHE
USA
93.56%
Other
6.44%
Sectors
BBC
Healthcare
95.06%
Other
4.94%
XHE
Healthcare
98.72%
Other
1.28%
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Diversification
BBC
Total weight of top 15 holdings out of 15
15.32%
XHE
Total weight of top 15 holdings out of 15
30.19%
Top 15 holdings
Data as of July 31, 2026
BBC
First Tracks Biotherapeutics, Inc.
1.57%
Monopar Therapeutics, Inc.
1.22%
MBX Biosciences, Inc.
1.14%
Zenas BioPharma, Inc.
1.09%
Xencor, Inc.
1.06%
Apogee Therapeutics, Inc.
1.00%
REGENXBIO, Inc.
0.96%
Oric Pharmaceuticals, Inc.
0.96%
Dyne Therapeutics, Inc.
0.93%
uniQure NV
0.91%
SELLAS Life Sciences Group, Inc.
0.91%
Nurix Therapeutics, Inc.
0.91%
Vor Biopharma, Inc.
0.89%
Erasca, Inc.
0.89%
Amylyx Pharmaceuticals, Inc.
0.88%
XHE
AtriCure, Inc.
2.14%
Glaukos Corp.
2.13%
Dentsply Sirona, Inc.
2.08%
Enovis Corp.
2.07%
Integer Holdings Corp.
2.07%
Butterfly Network, Inc.
2.06%
Neogen Corp.
2.05%
Artivion, Inc.
2.05%
Baxter International, Inc.
2.01%
CONMED Corp.
1.99%
Merit Medical Systems, Inc.
1.98%
QuidelOrtho Corp.
1.94%
ICU Medical, Inc.
1.88%
Tandem Diabetes Care, Inc.
1.88%
Inspire Medical Systems, Inc.
1.85%
Frequently asked questions about BBC and XHE
How have the BBC and XHE ETFs performed in 2026?
As of September 11, 2026, BBC is up 27.77% year-to-date (YTD), while XHE has returned 2.14%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or XHE?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$11M for XHE.
Which ETF is more volatile: BBC or XHE?
Over the past year, BBC had a volatility of 36.22%, while XHE experienced 22.69%.
Which ETF is bigger: BBC or XHE?
As of September 11, 2026, BBC holds $46.95 M in assets under management (AUM), while XHE manages $168.78 M.
What sectors do the BBC and XHE ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, XHE focuses on Healthcare.
What are the top holdings of the BBC ETF and XHE ETF?
BBC top holdings include First Tracks Biotherapeutics, Inc., Monopar Therapeutics, Inc. and MBX Biosciences, Inc.. XHE holds in its top three: AtriCure, Inc., Glaukos Corp. and Dentsply Sirona, Inc..
Which ETF is more diversified: BBC or XHE?
BBC holds 127 securities with 15.32% of its assets in the top 15. XHE has 66 securities and a top 15 weight of 30.19%.
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Latest news about BBC & XHE
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