BBCvsPTHETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. Invesco DWA Healthcare Momentum ETF (PTH) is part of the US Health Care segment. BBC's top 1 sector exposures are Healthcare. In contrast, PTH's top sector exposures are Healthcare and Consumer Non-Cyclicals. BBC is less expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.72% for PTH. BBC is up 27.77% year-to-date (YTD) with +$5M in YTD flows. PTH performs worse with 22.21% YTD performance, and +$131M in YTD flows. Run a side-by-side ETF comparison of BBC and PTH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs PTH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC PTH | -5.78%+1.34% | +17.22%+20.02% | +27.77%+22.21% | +102.82%+52.93% | +137.50%+70.20% | +6.45%+11.54% |
| Flows | BBC PTH | -+$25M | +$83K+$142M | +$5M+$131M | +$12M+$138M | +$16M+$78M | +$8M-$153M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC PTH | +33.39%+27.88% | +36.22%+26.02% | +37.22%+25.99% | +39.64%+25.74% |
| Max drawdown | BBC PTH | -11.65%-7.42% | -14.64%-11.91% | -54.25%-27.71% | -70.43%-49.87% |
| Max drawdown duration | BBC PTH | 23d40d | 60d140d | 340d353d | 1666d1735d |
Trading data
BBC | PTH | |
Last sale 9/14/2026 at 1:30 PM | $49.94 | $61.61 |
| Previous close 09/11/2026 | $49.39 | $60.77 |
| Consolidated volume 09/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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BBC | PTH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/14/2026 at 1:30 PM
Live
Closed
BBC | PTH | |
|---|---|---|
| Last price | $49.94 | $61.61 |
| 1D performance | +1.12% | +1.38% |
| AuM | $46.95 M | $283.73 M |
| E/R | 0.65% | 0.72% |
Characteristics
BBC | PTH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | Invesco |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | Dorsey Wright Healthcare Technical Leaders Index |
| N° of holdings | 127 | 54 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | October 12, 2006 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
86.49%
Other
13.51%
PTH
USA
89.98%
Other
10.02%
Sectors
BBC
Healthcare
95.06%
Other
4.94%
PTH
Healthcare
99.16%
Other
0.84%
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Diversification
BBC
Total weight of top 15 holdings out of 15
15.32%
PTH
Total weight of top 15 holdings out of 15
47.09%
Top 15 holdings
Data as of July 31, 2026
BBC
First Tracks Biotherapeutics, Inc.
1.57%
Monopar Therapeutics, Inc.
1.22%
MBX Biosciences, Inc.
1.14%
Zenas BioPharma, Inc.
1.09%
Xencor, Inc.
1.06%
Apogee Therapeutics, Inc.
1.00%
REGENXBIO, Inc.
0.96%
Oric Pharmaceuticals, Inc.
0.96%
Dyne Therapeutics, Inc.
0.93%
uniQure NV
0.91%
SELLAS Life Sciences Group, Inc.
0.91%
Nurix Therapeutics, Inc.
0.91%
Vor Biopharma, Inc.
0.89%
Erasca, Inc.
0.89%
Amylyx Pharmaceuticals, Inc.
0.88%
PTH
Roivant Sciences Ltd.
4.88%
Revolution Medicines, Inc.
4.85%
BrightSpring Health Services, Inc.
4.77%
Guardant Health, Inc.
4.50%
Axsome Therapeutics, Inc.
4.38%
Liquidia Corp.
3.17%
Erasca, Inc.
2.92%
Oruka Therapeutics, Inc.
2.54%
10X Genomics, Inc.
2.27%
Relay Therapeutics, Inc.
2.23%
Travere Therapeutics, Inc.
2.18%
Agilon Health, Inc.
2.13%
Oscar Health, Inc.
2.09%
Arrowhead Pharmaceuticals, Inc.
2.09%
Tango Therapeutics, Inc.
2.09%
Frequently asked questions about BBC and PTH
How have the BBC and PTH ETFs performed in 2026?
As of September 11, 2026, BBC is up 27.77% year-to-date (YTD), while PTH has returned 22.21%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or PTH?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$131M for PTH.
Which ETF is more volatile: BBC or PTH?
Over the past year, BBC had a volatility of 36.22%, while PTH experienced 26.02%.
Which ETF is bigger: BBC or PTH?
As of September 11, 2026, BBC holds $46.95 M in assets under management (AUM), while PTH manages $283.73 M.
What sectors do the BBC and PTH ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, PTH focuses on Healthcare.
What are the top holdings of the BBC ETF and PTH ETF?
BBC top holdings include First Tracks Biotherapeutics, Inc., Monopar Therapeutics, Inc. and MBX Biosciences, Inc.. PTH holds in its top three: Roivant Sciences Ltd., Revolution Medicines, Inc. and BrightSpring Health Services, Inc..
Which ETF is more diversified: BBC or PTH?
BBC holds 127 securities with 15.32% of its assets in the top 15. PTH has 54 securities and a top 15 weight of 47.09%.
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Latest news about BBC & PTH
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
BBC
Continued tightening of the U.S. labor market
September 23, 2022
PTH
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