BBCvsLFSCETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. F/m Emerald Life Sciences Innovation ETF (LFSC) is part of the Life Sciences segment. Both ETFs have the same top 3 sector exposures: and Healthcare. BBC is less expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.79% for LFSC. BBC is up 28.23% year-to-date (YTD) with +$5M in YTD flows. LFSC performs worse with 23.56% YTD performance, and +$8M in YTD flows. Run a side-by-side ETF comparison of BBC and LFSC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs LFSC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC LFSC | -5.49%-0.54% | +8.79%+20.11% | +28.23%+23.56% | +126.14%+85.69% | +122.92%n/a | +14.49%n/a |
| Flows | BBC LFSC | +$83K+$2M | +$5M+$3M | +$5M+$8M | +$11M+$17M | +$15M- | +$6M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC LFSC | +38.48%+26.23% | +35.85%+26.92% | +37.04%n/a | +39.65%n/a |
| Max drawdown | BBC LFSC | -11.52%-6.53% | -14.64%-16.25% | -54.25%n/a | -70.93%n/a |
| Max drawdown duration | BBC LFSC | 44d20d | 60d168d | 340dn/a | 1754dn/a |
Trading data
BBC | LFSC | |
Last sale 7/27/2026 at 7:57 PM | $49.74 | $45.24 |
| Previous close 07/27/2026 | $49.67 | $45.10 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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LFSC
is actively managed and doesn’t replicate an indexBBC | LFSC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 7:57 PM
Live
Closed
BBC | LFSC | |
|---|---|---|
| Last price | $49.74 | $45.24 |
| 1D performance | +0.14% | +0.30% |
| AuM | $47.12 M | $123.82 M |
| E/R | 0.65% | 0.79% |
Characteristics
BBC | LFSC | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | VIRTUS Investment Partners | Emerald Group |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | - |
| N° of holdings | 125 | 40 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | October 31, 2024 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
85.4%
Other
14.6%
LFSC
USA
90.9%
United Kingdom
7.04%
Other
2.06%
Sectors
BBC
Healthcare
95.19%
Other
4.81%
LFSC
Healthcare
98.03%
Other
1.97%
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Diversification
BBC
Total weight of top 15 holdings out of 15
14.01%
LFSC
Total weight of top 15 holdings out of 15
73.24%
Top 15 holdings
Data as of June 30, 2026
BBC
uniQure NV
1.18%
REGENXBIO, Inc.
1.01%
Apogee Therapeutics, Inc.
0.99%
Monopar Therapeutics, Inc.
0.97%
Jade Biosciences, Inc.
0.94%
Aktis Oncology, Inc.
0.94%
MBX Biosciences, Inc.
0.94%
Biohaven Ltd.
0.90%
Kymera Therapeutics, Inc.
0.89%
Cullinan Therapeutics, Inc.
0.89%
SELLAS Life Sciences Group, Inc.
0.89%
Generate Biomedicines, Inc.
0.88%
Nurix Therapeutics, Inc.
0.87%
Intellia Therapeutics, Inc.
0.87%
4D Molecular Therapeutics, Inc.
0.86%
LFSC
Travere Therapeutics, Inc.
8.37%
Cogent Biosciences, Inc.
7.18%
LivaNova Plc
7.04%
Spyre Therapeutics, Inc.
6.71%
Guardant Health, Inc.
5.56%
Corcept Therapeutics, Inc.
5.27%
Mirum Pharmaceuticals, Inc.
5.25%
BillionToOne, Inc.
4.25%
Cytokinetics, Inc.
4.13%
Veradermics, Inc.
3.76%
United Therapeutics Corp.
3.55%
Trevi Therapeutics, Inc.
3.50%
Savara, Inc.
3.20%
Dianthus Therapeutics, Inc.
2.77%
Nektar Therapeutics
2.70%
Frequently asked questions about BBC and LFSC
How have the BBC and LFSC ETFs performed in 2026?
As of July 27, 2026, BBC is up 28.23% year-to-date (YTD), while LFSC has returned 23.56%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or LFSC?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$8M for LFSC.
Which ETF is more volatile: BBC or LFSC?
Over the past year, BBC had a volatility of 35.85%, while LFSC experienced 26.92%.
Which ETF is bigger: BBC or LFSC?
As of July 27, 2026, BBC holds $47.12 M in assets under management (AUM), while LFSC manages $123.82 M.
What sectors do the BBC and LFSC ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, LFSC focuses on Healthcare.
What are the top holdings of the BBC ETF and LFSC ETF?
BBC top holdings include uniQure NV, REGENXBIO, Inc. and Apogee Therapeutics, Inc.. LFSC holds in its top three: Travere Therapeutics, Inc., Cogent Biosciences, Inc. and LivaNova Plc.
Which ETF is more diversified: BBC or LFSC?
BBC holds 125 securities with 14.01% of its assets in the top 15. LFSC has 40 securities and a top 15 weight of 73.24%.
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Latest news about BBC & LFSC
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