BBCvsIBRNETF Comparison
VS
Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. iShares Neuroscience and Healthcare ETF (IBRN) is part of the Healthcare Technology segment. BBC's top 1 sector exposures are Healthcare. In contrast, IBRN's top sector exposures are Healthcare and Non-Corporate. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.47% for IBRN. BBC is up 13.68% year-to-date (YTD) with +$2M in YTD flows. IBRN performs worse with 2.14% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of BBC and IBRN below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
Find out how industry players manage ETF portfolios. Discover our library of Model portfolios
BBC vs IBRN performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC IBRN | -4.54%-1.26% | -10.21%-11.74% | +13.68%+2.14% | +39.31%+9.73% | +159.89%+72.73% | +0.98%n/a |
| Flows | BBC IBRN | -$2M- | -$2M+$2M | +$2M+$2M | +$10M+$2M | +$14M+$759K | +$6M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC IBRN | +37.13%+26.89% | +37.04%+26.73% | +37.66%+25.48% | +40.00%n/a |
| Max drawdown | BBC IBRN | -29.70%-26.38% | -29.70%-26.38% | -54.25%-34.98% | -70.04%n/a |
| Max drawdown duration | BBC IBRN | 70d70d | 70d70d | 340d338d | 1625dn/a |
Trading data
BBC | IBRN | |
Last sale 10/28/2026 at 7:57 PM | $43.95 | $32.92 |
| Previous close 10/28/2026 | $42.87 | $32.24 |
| Consolidated volume 10/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
Create an account to view replication metrics
Join for free
BBC | IBRN | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
Advertisement
Main metrics
Last update 10/28/2026 at 7:57 PM
Live
Closed
BBC | IBRN | |
|---|---|---|
| Last price | $43.95 | $32.92 |
| 1D performance | +2.51% | +2.11% |
| AuM | $39.58 M | $6.60 M |
| E/R | 0.65% | 0.47% |
Characteristics
BBC | IBRN | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | iShares |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | NYSE FactSet Global Neuro Biopharma and MedTech Index |
| N° of holdings | 127 | 69 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | August 24, 2022 |
| ESG | No | No |
Advertisement
Exposure
Countries
BBC
USA
87.24%
Other
12.76%
IBRN
USA
73.41%
Other
26.59%
Sectors
BBC
Healthcare
96.27%
Other
3.73%
IBRN
Healthcare
99.86%
Other
0.14%
Advertisement
Diversification
BBC
Total weight of top 15 holdings out of 15
17.14%
IBRN
Total weight of top 15 holdings out of 15
62.03%
Top 15 holdings
Data as of August 31, 2026
BBC
Amylyx Pharmaceuticals, Inc.
1.50%
First Tracks Biotherapeutics, Inc.
1.48%
AbCellera Biologics, Inc.
1.38%
Xencor, Inc.
1.36%
Monopar Therapeutics, Inc.
1.12%
MBX Biosciences, Inc.
1.11%
uniQure NV
1.09%
Replimune Group, Inc.
1.06%
4D Molecular Therapeutics, Inc.
1.04%
SELLAS Life Sciences Group, Inc.
1.04%
Alto Neuroscience, Inc.
1.00%
LB Pharmaceuticals, Inc.
1.00%
Oric Pharmaceuticals, Inc.
0.99%
Zenas BioPharma, Inc.
0.98%
Cullinan Therapeutics, Inc.
0.98%
IBRN
Praxis Precision Medicines, Inc.
5.21%
Dianthus Therapeutics, Inc.
4.96%
ACADIA Pharmaceuticals, Inc.
4.93%
Scholar Rock Holding Corp.
4.85%
Xenon Pharmaceuticals, Inc.
4.40%
argenx SE
4.37%
Arrowhead Pharmaceuticals, Inc.
4.26%
Biogen, Inc.
4.19%
Alkermes Plc
4.15%
PTC Therapeutics, Inc.
3.70%
Denali Therapeutics, Inc.
3.56%
Neurocrine Biosciences, Inc.
3.55%
Dyne Therapeutics, Inc.
3.38%
Edgewise Therapeutics, Inc.
3.30%
Axsome Therapeutics, Inc.
3.23%
Frequently asked questions about BBC and IBRN
How have the BBC and IBRN ETFs performed in 2026?
As of October 28, 2026, BBC is up 13.68% year-to-date (YTD), while IBRN has returned 2.14%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or IBRN?
Year-to-date, the BBC ETF saw +$2M in flows, compared to +$2M for IBRN.
Which ETF is more volatile: BBC or IBRN?
Over the past year, BBC had a volatility of 37.04%, while IBRN experienced 26.73%.
Which ETF is bigger: BBC or IBRN?
As of October 28, 2026, BBC holds $39.58 M in assets under management (AUM), while IBRN manages $6.60 M.
What sectors do the BBC and IBRN ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, IBRN focuses on Healthcare.
What are the top holdings of the BBC ETF and IBRN ETF?
BBC top holdings include Amylyx Pharmaceuticals, Inc., First Tracks Biotherapeutics, Inc. and AbCellera Biologics, Inc.. IBRN holds in its top three: Praxis Precision Medicines, Inc., Dianthus Therapeutics, Inc. and ACADIA Pharmaceuticals, Inc..
Which ETF is more diversified: BBC or IBRN?
BBC holds 127 securities with 17.14% of its assets in the top 15. IBRN has 69 securities and a top 15 weight of 62.03%.
Advertisement
Latest news about BBC & IBRN
Advertisement
