BBCvsIBRNETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. iShares Neuroscience and Healthcare ETF (IBRN) is part of the Healthcare Technology segment. BBC's top 1 sector exposures are Healthcare. In contrast, IBRN's top sector exposures are Healthcare and Non-Corporate. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.47% for IBRN. BBC is up 27.77% year-to-date (YTD) with +$5M in YTD flows. IBRN performs worse with 15.7% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of BBC and IBRN below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs IBRN performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC IBRN | -5.78%-4.78% | +17.22%+7.91% | +27.77%+15.70% | +102.82%+45.60% | +137.50%+66.79% | +6.45%n/a |
| Flows | BBC IBRN | -- | +$83K+$2M | +$5M+$2M | +$12M+$2M | +$16M+$759K | +$8M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC IBRN | +33.39%+23.60% | +36.22%+25.91% | +37.22%+25.19% | +39.64%n/a |
| Max drawdown | BBC IBRN | -11.65%-9.28% | -14.64%-9.28% | -54.25%-34.98% | -70.43%n/a |
| Max drawdown duration | BBC IBRN | 23d40d | 60d40d | 340d338d | 1666dn/a |
Trading data
BBC | IBRN | |
Last sale 9/11/2026 at 1:30 PM | $49.39 | $37.43 |
| Previous close 09/10/2026 | $49.91 | $37.33 |
| Consolidated volume 09/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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BBC | IBRN | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 9/11/2026 at 1:30 PM
Live
Closed
BBC | IBRN | |
|---|---|---|
| Last price | $49.39 | $37.43 |
| 1D performance | -1.05% | +0.26% |
| AuM | $46.95 M | $7.48 M |
| E/R | 0.65% | 0.47% |
Characteristics
BBC | IBRN | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | iShares |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | NYSE FactSet Global Neuro Biopharma and MedTech Index |
| N° of holdings | 127 | 69 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | August 24, 2022 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
86.49%
Other
13.51%
IBRN
USA
73.57%
Other
26.43%
Sectors
BBC
Healthcare
95.06%
Other
4.94%
IBRN
Healthcare
99.87%
Other
0.13%
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Diversification
BBC
Total weight of top 15 holdings out of 15
15.32%
IBRN
Total weight of top 15 holdings out of 15
64.26%
Top 15 holdings
Data as of July 31, 2026
BBC
First Tracks Biotherapeutics, Inc.
1.57%
Monopar Therapeutics, Inc.
1.22%
MBX Biosciences, Inc.
1.14%
Zenas BioPharma, Inc.
1.09%
Xencor, Inc.
1.06%
Apogee Therapeutics, Inc.
1.00%
REGENXBIO, Inc.
0.96%
Oric Pharmaceuticals, Inc.
0.96%
Dyne Therapeutics, Inc.
0.93%
uniQure NV
0.91%
SELLAS Life Sciences Group, Inc.
0.91%
Nurix Therapeutics, Inc.
0.91%
Vor Biopharma, Inc.
0.89%
Erasca, Inc.
0.89%
Amylyx Pharmaceuticals, Inc.
0.88%
IBRN
Dianthus Therapeutics, Inc.
5.45%
Xenon Pharmaceuticals, Inc.
4.83%
Praxis Precision Medicines, Inc.
4.72%
ACADIA Pharmaceuticals, Inc.
4.66%
Arrowhead Pharmaceuticals, Inc.
4.65%
Alkermes Plc
4.55%
Neurocrine Biosciences, Inc.
4.41%
Scholar Rock Holding Corp.
4.31%
PTC Therapeutics, Inc.
4.15%
Biogen, Inc.
4.15%
Axsome Therapeutics, Inc.
3.93%
argenx SE
3.82%
Denali Therapeutics, Inc.
3.76%
Dyne Therapeutics, Inc.
3.53%
Edgewise Therapeutics, Inc.
3.35%
Frequently asked questions about BBC and IBRN
How have the BBC and IBRN ETFs performed in 2026?
As of September 11, 2026, BBC is up 27.77% year-to-date (YTD), while IBRN has returned 15.7%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or IBRN?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$2M for IBRN.
Which ETF is more volatile: BBC or IBRN?
Over the past year, BBC had a volatility of 36.22%, while IBRN experienced 25.91%.
Which ETF is bigger: BBC or IBRN?
As of September 11, 2026, BBC holds $46.95 M in assets under management (AUM), while IBRN manages $7.48 M.
What sectors do the BBC and IBRN ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, IBRN focuses on Healthcare.
What are the top holdings of the BBC ETF and IBRN ETF?
BBC top holdings include First Tracks Biotherapeutics, Inc., Monopar Therapeutics, Inc. and MBX Biosciences, Inc.. IBRN holds in its top three: Dianthus Therapeutics, Inc., Xenon Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc..
Which ETF is more diversified: BBC or IBRN?
BBC holds 127 securities with 15.32% of its assets in the top 15. IBRN has 69 securities and a top 15 weight of 64.26%.
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Latest news about BBC & IBRN
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