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Clough Capital’s CEO Vince Lorusso explains why rising dispersion and AI-led disruption may be creating fertile ground for active equity strategies.

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In this edition of Ask the Manager, we sit down with Vince Lorusso, CEO and Portfolio Manager at Clough Capital Partners, to unpack why today’s market backdrop may be particularly well-suited to active equity investing. With index valuations reflecting much of the optimism around growth and innovation, Lorusso highlights the growing dispersion beneath the surface—driven in large part by the rapid build-out of AI and digital infrastructure—as fertile ground for selective, research-driven strategies. From navigating macro uncertainty to identifying structural winners and losers, he shares how Clough is positioning its actively managed ETFs to seek to capture opportunity while managing risk in an increasingly complex market environment.
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We think this is an unusually attractive environment for active managers. Index levels and valuations already discount a lot of good news, but the dispersion beneath the surface is enormous. The AI and digital infrastructure build‑out is creating clear winners and clear losers, which is exactly when a research‑driven, selective approach can add value versus simply owning the market.
We view AI less as a buzzword and more as a multi‑year capital investment cycle touching semiconductors, networking, software, and parts of industrials and services. Our focus is on companies that either enable this build‑out or can harness productivity gains to improve margins and returns on capital. At the same time, we’re very aware that many business models will be pressured by these same forces, which informs both our long and short ideas.
We don’t try to forecast every data print or central bank move. Instead, we anchor on structural forces—technology adoption, demographic trends, and capital spending cycles—and then assess how macro conditions may accelerate or delay them at the margin. That allows us to stay invested in high‑conviction themes while using position sizing, hedging, and the short book where appropriate to manage volatility for clients.
On the opportunity side, we see persistent “shortages” in areas like advanced compute, bandwidth, and certain specialized industrial assets, where demand visibility and pricing power are strong. On the risk side, we’re cautious on companies that have benefited from unusually favorable conditions—whether it’s cheap capital, temporarily elevated margins, or legacy market share—that may not be sustainable as technology and policy evolve.
Active ETFs let us deliver institutional‑style research and portfolio management in a liquid, tax‑efficient, and transparent vehicle. For investors, that means access to our best ideas and risk management in a format that trades intraday on an exchange, sits easily in a broader asset allocation, and avoids some of the constraints of traditional mutual funds or private vehicles.
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Vince Lorusso is the CEO and a Portfolio Manager at Clough Capital Partners, responsible for the firm’s actively managed ETF strategies, including the Clough Select Equity ETF
Please note this article is for information purposes only and does not in any way constitute investment advice. It is essential that you seek advice from a registered financial professional prior to making any investment decision.
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