New

Turn ETF ideas into real portfolios. Try the builder now →

Ask the Manager

Ask the Manager: Vince Lorusso on Active Equity in an AI-Driven Market

Clough Capital’s CEO Vince Lorusso explains why rising dispersion and AI-led disruption may be creating fertile ground for active equity strategies.

ETF Central
By ETF Central Team · April 23, 2026
Share
Ask the Manager: Vince Lorusso on Active Equity in an AI-Driven Market

Keep up with what matters in ETFs

Get timely ETF insights, market trends, and top ideas straight to your inbox.

Your newsletter subscriptions with us are subject to ETF Central's Privacy Policy and Terms and Conditions.

In this edition of Ask the Manager, we sit down with Vince Lorusso, CEO and Portfolio Manager at Clough Capital Partners, to unpack why today’s market backdrop may be particularly well-suited to active equity investing. With index valuations reflecting much of the optimism around growth and innovation, Lorusso highlights the growing dispersion beneath the surface—driven in large part by the rapid build-out of AI and digital infrastructure—as fertile ground for selective, research-driven strategies. From navigating macro uncertainty to identifying structural winners and losers, he shares how Clough is positioning its actively managed ETFs to seek to capture opportunity while managing risk in an increasingly complex market environment.

ETF Central Weekly Newsletter

Like what you're reading?

Stay in the loop — get the latest ETF insights: trends, analysis, and expert picks.

After signing up, you will receive occasional emails from ETF Central and its partners. See our Terms of use.

How would you describe the backdrop for active equity investing right now?

We think this is an unusually attractive environment for active managers. Index levels and valuations already discount a lot of good news, but the dispersion beneath the surface is enormous. The AI and digital infrastructure build‑out is creating clear winners and clear losers, which is exactly when a research‑driven, selective approach can add value versus simply owning the market.

What role do you see AI and other secular themes playing in portfolios over the next few years?

We view AI less as a buzzword and more as a multi‑year capital investment cycle touching semiconductors, networking, software, and parts of industrials and services. Our focus is on companies that either enable this build‑out or can harness productivity gains to improve margins and returns on capital. At the same time, we’re very aware that many business models will be pressured by these same forces, which informs both our long and short ideas.

How do you balance near‑term macro uncertainty with those longer‑term themes?

We don’t try to forecast every data print or central bank move. Instead, we anchor on structural forces—technology adoption, demographic trends, and capital spending cycles—and then assess how macro conditions may accelerate or delay them at the margin. That allows us to stay invested in high‑conviction themes while using position sizing, hedging, and the short book where appropriate to manage volatility for clients.

Where do you see the biggest opportunities and risks for equity investors today?

On the opportunity side, we see persistent “shortages” in areas like advanced compute, bandwidth, and certain specialized industrial assets, where demand visibility and pricing power are strong. On the risk side, we’re cautious on companies that have benefited from unusually favorable conditions—whether it’s cheap capital, temporarily elevated margins, or legacy market share—that may not be sustainable as technology and policy evolve.

Why has Clough chosen the active ETF structure for these strategies?

Active ETFs let us deliver institutional‑style research and portfolio management in a liquid, tax‑efficient, and transparent vehicle. For investors, that means access to our best ideas and risk management in a format that trades intraday on an exchange, sits easily in a broader asset allocation, and avoids some of the constraints of traditional mutual funds or private vehicles.

Can you briefly describe the Clough Select Equity ETF (CBSE) and its role in a portfolio?

CBSE

is our high‑conviction, long‑only equity ETF that seeks capital appreciation with lower volatility than the broader market. We build a focused portfolio of companies we believe have above‑average financial characteristics and attractive thematic tailwinds, and we aim for it to serve as a core equity allocation for investors who want active stock selection rather than pure index exposure.

How does the Clough Hedged Equity ETF (CBLS) differ, and who is it for?

CBLS

is an actively managed, net‑long hedged equity ETF that combines a long book of our best ideas with a targeted short book and other tools to help manage downside risk. It’s designed for investors who want to participate in equity upside but are sensitive to volatility and drawdowns—particularly in environments where headline risk, dispersion, and factor rotations are elevated.

 

About Vince Lorusso

Vince Lorusso is the CEO and a Portfolio Manager at Clough Capital Partners, responsible for the firm’s actively managed ETF strategies, including the Clough Select Equity ETF

and the Clough Hedged Equity ETF
CBLS
-4.02%
. Clough Capital is a Boston‑based, research‑driven investment firm with more than two decades of experience investing across sectors, geographies, and market cycles.

 

Please note this article is for information purposes only and does not in any way constitute investment advice. It is essential that you seek advice from a registered financial professional prior to making any investment decision.

Advertisement
ETF U
Become a better investor with NYSE: The Home of ETFs
Visit the ETF U homepage
ETF Guides
Advertisement

Recent educational content

ETF Investing Trends - First Look

First Look ETF

First Look ETF: Income, International, and Cash Flow ETFs

In this season 6 episode of First Look ETF, Stephanie Stanton ‪@etfguide‬ examines the latest ETF marketplace trends with NYSE and guests.

ETF Guide
By ETF Guide · October 20, 2026
Tidal ETF Industry KPIs

ETF Trends

ETF Industry KPIs October 5, 2026

This week’s KPI data overview highlights key metrics and trends shaping the ETF landscape.

Tidal
By Tidal · October 6, 2026
Tidal ETF Industry KPIs

ETF Trends

ETF Industry KPIs September 28, 2026

This week’s KPI data overview highlights key metrics and trends shaping the ETF landscape.

Tidal
By Tidal · September 29, 2026
Tidal ETF Industry KPIs

ETF Trends

ETF Industry KPIs September 22, 2026

This week’s KPI data overview highlights key metrics and trends shaping the ETF landscape.

Tidal
By Tidal · September 23, 2026

Browse all educational columns

Advertisement
New Report

ETFs’ Next Act: From Access to Selection

With 1,790 new products launched by July 2026, choosing is harder than ever. Our Global ETF Survey 2026, built on 620 professional investors and allocators, shows how active, fixed income, options-based and thematic ETFs are reshaping fund selection.

Global ETF Survey 2026
Sign up for our weekly newsletter
The latest news from The Home of ETFs, delivered straight to your inbox.