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XLVIvsFTXHETF Comparison

ETF 1

XLVI

State Street Health Care Select Sector SPDR Premium Income Fund

This fund is part of

Options Strategies

-0.24%

Full XLVI fund page

VS

ETF 2

FTXH

First Trust Nasdaq Pharmaceuticals ETF

This fund is part of

US Health Care

-2.15%

Full FTXH fund page

State Street Health Care Select Sector SPDR Premium Income Fund (XLVI) belongs to the Options Strategies segment. First Trust Nasdaq Pharmaceuticals ETF (FTXH) is part of the US Health Care segment. XLVI's top 2 sector exposures are Healthcare and Consumer Non-Cyclicals. In contrast, FTXH's top sector exposures are Healthcare. XLVI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.6% for FTXH. XLVI is up 6.61% year-to-date (YTD) with +$14M in YTD flows. FTXH performs better with 27.27% YTD performance, and +$980M in YTD flows. Run a side-by-side ETF comparison of XLVI and FTXH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XLVI vs FTXH performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 09/08/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	XLVI FTXH	-2.92%+7.11%	+5.01%+18.08%	+6.61%+27.27%	+17.41%+51.23%	n/a+63.65%	n/a+70.10%
Flows	XLVI FTXH	+$3M+$84M	+$10M+$968M	+$14M+$980M	+$24M+$983M	-+$975M	-+$975M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	XLVI FTXH	+11.87%+19.67%	+11.07%+17.61%	n/a+16.95%	n/a+16.32%
Max drawdown	XLVI FTXH	-3.95%-4.43%	-8.21%-7.50%	n/a-19.32%	n/a-19.32%
Max drawdown duration	XLVI FTXH	14d20d	115d99d	n/a393d	n/a393d

Trading data

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	XLVI	FTXH
Last sale 9/9/2026 at 1:30 PM	$25.87	$40.70
Previous close 09/08/2026	$25.96	$40.91
Consolidated volume 09/08/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of August 31, 2026

1-year trailing difference

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XLVI

is actively managed and doesn’t replicate an index

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	XLVI	FTXH
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/9/2026 at 1:30 PM

Live

Closed

	XLVI	FTXH
Last price	$25.87	$40.70
1D performance	-0.35%	-0.51%
AuM	$24.91 M	$1.08 B
E/R	0.35%	0.6%

Characteristics

	XLVI	FTXH
Management strategy	Active	Passive
Provider	State Street Investment Management	First Trust
Benchmark	-	NASDAQ US Smart Pharmaceuticals Index
N° of holdings	59	49
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	July 30, 2025	September 20, 2016
ESG	No	No

More XLVI data on Trackinsight

More FTXH data on Trackinsight

Exposure

Countries

XLVI

USA

97.34%

Other

2.66%

FTXH

USA

95.79%

Other

4.21%

Sectors

XLVI

Healthcare

97.32%

Other

2.68%

FTXH

Healthcare

99.86%

Other

0.14%

Diversification

XLVI

Total weight of top 15 holdings out of 15

71.63%

FTXH

Total weight of top 15 holdings out of 15

66.98%

Top 15 holdings

Data as of July 31, 2026

XLVI

Eli Lilly & Co.

15.45%

Johnson & Johnson

10.49%

AbbVie, Inc.

7.54%

UnitedHealth Group, Inc.

6.40%

Merck & Co., Inc.

5.47%

Thermo Fisher Scientific, Inc.

3.63%

Amgen, Inc.

3.53%

Abbott Laboratories

3.13%

Gilead Sciences, Inc.

2.75%

Pfizer Inc.

2.42%

Bristol Myers Squibb Co.

2.27%

CVS Health Corp.

2.27%

Intuitive Surgical, Inc.

2.13%

Danaher Corp.

2.09%

Vertex Pharmaceuticals, Inc.

2.06%

FTXH

Merck & Co., Inc.

7.58%

Eli Lilly & Co.

7.43%

AbbVie, Inc.

7.11%

Johnson & Johnson

6.78%

Bristol Myers Squibb Co.

6.61%

Amgen, Inc.

3.53%

Biogen, Inc.

3.52%

Vertex Pharmaceuticals, Inc.

3.43%

Viatris, Inc.

3.40%

Regeneron Pharmaceuticals, Inc.

3.34%

Pfizer Inc.

3.17%

Cardinal Health, Inc.

3.14%

Gilead Sciences, Inc.

3.03%

Incyte Corp.

2.48%

United Therapeutics Corp.

2.43%

Frequently asked questions about XLVI and FTXH

How have the XLVI and FTXH ETFs performed in 2026?

As of September 8, 2026, XLVI is up 6.61% year-to-date (YTD), while FTXH has returned 27.27%. That puts FTXH better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or FTXH?

Year-to-date, the XLVI ETF saw +$14M in flows, compared to +$980M for FTXH.

Which ETF is more volatile: XLVI or FTXH?

Over the past year, XLVI had a volatility of 11.07%, while FTXH experienced 17.61%.

Which ETF is bigger: XLVI or FTXH?

As of September 8, 2026, XLVI holds $24.91 M in assets under management (AUM), while FTXH manages $1.08 B.

What sectors do the XLVI and FTXH ETFs invest in?

XLVI leans toward sectors like Healthcare. Meanwhile, FTXH focuses on Healthcare.

What are the top holdings of the XLVI ETF and FTXH ETF?

XLVI top holdings include Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc.. FTXH holds in its top three: Merck & Co., Inc., Eli Lilly & Co. and AbbVie, Inc..

XLVIvsFTXHETF Comparison

State Street Health Care Select Sector SPDR Premium Income Fund

First Trust Nasdaq Pharmaceuticals ETF

XLVI vs FTXH performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the XLVI and FTXH ETFs performed in 2026?

As of September 8, 2026, XLVI is up 6.61% year-to-date (YTD), while FTXH has returned 27.27%. That puts FTXH better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or FTXH?

Year-to-date, the XLVI ETF saw +$14M in flows, compared to +$980M for FTXH.

Which ETF is more volatile: XLVI or FTXH?

Over the past year, XLVI had a volatility of 11.07%, while FTXH experienced 17.61%.

Which ETF is bigger: XLVI or FTXH?

As of September 8, 2026, XLVI holds $24.91 M in assets under management (AUM), while FTXH manages $1.08 B.

What sectors do the XLVI and FTXH ETFs invest in?

XLVI leans toward sectors like Healthcare. Meanwhile, FTXH focuses on Healthcare.

What are the top holdings of the XLVI ETF and FTXH ETF?

XLVI top holdings include Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc.. FTXH holds in its top three: Merck & Co., Inc., Eli Lilly & Co. and AbbVie, Inc..

Which ETF is more diversified: XLVI or FTXH?

XLVI holds 59 securities with 71.63% of its assets in the top 15. FTXH has 49 securities and a top 15 weight of 66.98%.

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