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XLVIvsFTXHETF Comparison

ETF 1
XLVI

The Health Care Select Sector SPDR Premium Income Fund

This fund is part of
Options Strategies
-0.04%
Full XLVI fund page
VS
ETF 2
FTXH

First Trust Nasdaq Pharmaceuticals ETF

This fund is part of
US Health Care
-0.31%
Full FTXH fund page

The Health Care Select Sector SPDR Premium Income Fund (XLVI) belongs to the Options Strategies segment. First Trust Nasdaq Pharmaceuticals ETF (FTXH) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. XLVI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.6% for FTXH. XLVI is up 0.28% year-to-date (YTD) with +$2M in YTD flows. FTXH performs better with 4.68% YTD performance, and +$7M in YTD flows. Run a side-by-side ETF comparison of XLVI and FTXH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XLVI vs FTXH performance and flow charts

Performance

-2.0-1.00.01.02.0%Feb 11Feb 19Feb 26Mar 5

Cumulative Flows

0 M1 M2 M3 M4 M5 MFeb 11Feb 19Feb 26Mar 5

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Historic performance and flows
Data as of 03/11/2026
1M3MYTD1Y3Y5Y
Perf.
XLVI
FTXH
-1.07%-1.29%
+1.89%+6.38%
+0.28%+4.68%
n/a+24.12%
n/a+42.55%
n/a+41.63%
Flows
XLVI
FTXH
+$788K+$5M
+$3M+$9M
+$2M+$7M
-+$10M
--$13M
-+$7M
Volatility and drawdown
3M1Y3Y5Y
Volatility
XLVI
FTXH
+10.15%+15.28%
n/a+20.56%
n/a+15.87%
n/a+15.66%
Max drawdown
XLVI
FTXH
-3.26%-4.33%
n/a-16.42%
n/a-19.32%
n/a-19.32%
Max drawdown duration
XLVI
FTXH
10d10d
n/a165d
n/a393d
n/a393d
Trading data

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XLVI
FTXH
Last sale
3/12/2026 at 1:30 PM
$25.54
$33.78
Previous close
03/11/2026
$25.92
$34.46
Consolidated volume
03/11/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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XLVI
is actively managed and doesn’t replicate an index

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XLVI
FTXH
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/12/2026 at 1:30 PM
Live
Closed
XLVI
FTXH
Last price
$25.54
$33.78
1D performance
-1.47%
-1.96%
AuM$13.24 M$29.30 M
E/R0.35%0.6%
Characteristics
XLVI
FTXH
Management strategyActivePassive
ProviderSPDRFirst Trust
Benchmark-NASDAQ US Smart Pharmaceuticals Index
N° of holdings5749
Asset class-Equities
Trailing 12m distribution yield
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Inception dateJuly 30, 2025September 20, 2016
ESGNoNo
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Exposure

Countries

XLVI
USA
96.37%
Other
3.63%
FTXH
USA
95.63%
Other
4.37%

Sectors

XLVI
Health Care
97.65%
Other
2.35%
FTXH
Health Care
98.8%
Other
1.2%
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Diversification

XLVI

Total weight of top 15 holdings out of 15

69.69%
FTXH

Total weight of top 15 holdings out of 15

71.63%

Top 15 holdings

Data as of January 31, 2026
XLVI
LILLY
14.60%
JOHNSON&JOHNSON
9.71%
ABBVIE
6.99%
MERCK & CO INC
4.85%
UNITEDHEALTH GRP
4.61%
THERMO FISHER SCIENTIFIC
3.85%
ABBOTT LABS
3.37%
AMGEN-T
3.26%
INTUITIVE SURGICAL
3.17%
GILEAD SCIENCES
3.12%
PFIZER
2.66%
BOSTON SCIENTIFIC
2.46%
DANAHER
2.44%
MEDTRONIC PLC
2.34%
STRYKER
2.25%
FTXH
MERCK & CO INC
7.83%
JOHNSON&JOHNSON
7.66%
BRISTOL-MYERS SQUIBB
6.97%
PFIZER
6.38%
ABBVIE
6.33%
CARDINAL HEALTH
4.31%
LILLY
4.23%
BIOGEN INC
3.99%
REGENERON PHARMACEUTICALS
3.81%
GILEAD SCIENCES
3.75%
VIATRIS INC
3.71%
VERTEX PHARMACEUTICALS
3.59%
AMGEN-T
3.55%
UTD THERAPEUT
3.14%
ZOETIS INC
2.38%
Frequently asked questions about XLVI and FTXH

How have the XLVI and FTXH ETFs performed in 2026?

As of March 11, 2026, XLVI is up 0.28% year-to-date (YTD), while FTXH has returned 4.68%. That puts FTXH better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or FTXH?

Year-to-date, the XLVI ETF saw +$2M in flows, compared to +$7M for FTXH.

Which ETF is bigger: XLVI or FTXH?

As of March 11, 2026, XLVI holds $13.24 M in assets under management (AUM), while FTXH manages $29.30 M.

What sectors do the XLVI and FTXH ETFs invest in?

XLVI leans toward sectors like Health Care. Meanwhile, FTXH focuses on Health Care.

What are the top holdings of the XLVI ETF and FTXH ETF?

XLVI top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. FTXH holds in its top three: MERCK & CO INC, JOHNSON&JOHNSON and BRISTOL-MYERS SQUIBB.

Which ETF is more diversified: XLVI or FTXH?

XLVI holds 60 securities with 69.69% of its assets in the top 15. FTXH has 50 securities and a top 15 weight of 71.63%.

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