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XLVIvsFTXHETF Comparison

ETF 1
XLVI

State Street Health Care Select Sector SPDR Premium Income Fund

This fund is part of
Options Strategies
-0.18%
VS
ETF 2
FTXH

First Trust Nasdaq Pharmaceuticals ETF

This fund is part of
US Health Care
+1.38%

State Street Health Care Select Sector SPDR Premium Income Fund (XLVI) belongs to the Options Strategies segment. First Trust Nasdaq Pharmaceuticals ETF (FTXH) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. XLVI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.6% for FTXH. XLVI is up 2.13% year-to-date (YTD) with +$4M in YTD flows. FTXH performs better with 6.85% YTD performance, and +$12M in YTD flows. Run a side-by-side ETF comparison of XLVI and FTXH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XLVI vs FTXH performance and flow charts

Performance

0.02.04.06.0%May 8May 15May 22May 29Jun 5

Cumulative Flows

0500,0001,000,0001,500,0002,000,000May 8May 15May 22May 29Jun 5

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 06/09/2026
1M3MYTD1Y3Y5Y
Perf.
XLVI
FTXH
+6.44%+3.68%
+1.06%+1.74%
+2.13%+6.85%
n/a+36.41%
n/a+40.67%
n/a+47.41%
Flows
XLVI
FTXH
+$2M-
+$2M+$5M
+$4M+$12M
-+$9M
--$3M
-+$7M
Volatility and drawdown
3M1Y3Y5Y
Volatility
XLVI
FTXH
+13.59%+17.68%
n/a+16.93%
n/a+16.24%
n/a+15.91%
Max drawdown
XLVI
FTXH
-6.06%-4.70%
n/a-7.50%
n/a-19.32%
n/a-19.32%
Max drawdown duration
XLVI
FTXH
86d28d
n/a99d
n/a393d
n/a393d
Trading data

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XLVI
FTXH
Last sale
6/10/2026 at 1:30 PM
$25.50
$35.33
Previous close
06/09/2026
$25.60
$35.64
Consolidated volume
06/09/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of May 29, 2026
1-year trailing difference

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XLVI
is actively managed and doesn’t replicate an index

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XLVI
FTXH
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 6/10/2026 at 1:30 PM
Live
Closed
XLVI
FTXH
Last price
$25.50
$35.33
1D performance
-0.38%
-0.87%
AuM$14.84 M$35.13 M
E/R0.35%0.6%
Characteristics
XLVI
FTXH
Management strategyActivePassive
ProviderState Street Investment ManagementFirst Trust
Benchmark-NASDAQ US Smart Pharmaceuticals Index
N° of holdings5547
Asset class-Equities
Trailing 12m distribution yield
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Inception dateJuly 30, 2025September 20, 2016
ESGNoNo
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Exposure

Countries

XLVI
USA
96.67%
Other
3.33%
FTXH
USA
93.7%
Other
6.3%

Sectors

XLVI
Health Care
97.69%
Other
2.31%
FTXH
Health Care
97.61%
Other
2.39%
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Diversification

XLVI

Total weight of top 15 holdings out of 15

70.39%
FTXH

Total weight of top 15 holdings out of 15

69.57%

Top 15 holdings

Data as of April 30, 2026
XLVI
LILLY
13.98%
JOHNSON&JOHNSON
10.46%
ABBVIE
7.05%
UNITEDHEALTH GRP
6.34%
MERCK & CO INC
5.12%
AMGEN-T
3.52%
THERMO FISHER SCIENTIFIC
3.40%
INTUITIVE SURGICAL
3.07%
GILEAD SCIENCES
3.06%
ABBOTT LABS
2.98%
PFIZER
2.87%
BRISTOL-MYERS SQUIBB
2.33%
DANAHER
2.13%
VERTEX PHARMACEUTICALS
2.05%
STRYKER
2.05%
FTXH
BRISTOL-MYERS SQUIBB
7.25%
JOHNSON&JOHNSON
7.12%
MERCK & CO INC
6.90%
ABBVIE
6.61%
LILLY
6.45%
VIATRIS INC
3.85%
PFIZER
3.72%
BIOGEN INC
3.71%
REGENERON PHARMACEUTICALS
3.63%
CARDINAL HEALTH
3.48%
ZOETIS INC
3.45%
AMGEN-T
3.40%
GILEAD SCIENCES
3.37%
VERTEX PHARMACEUTICALS
3.36%
UTD THERAPEUT
3.26%
Frequently asked questions about XLVI and FTXH

How have the XLVI and FTXH ETFs performed in 2026?

As of June 9, 2026, XLVI is up 2.13% year-to-date (YTD), while FTXH has returned 6.85%. That puts FTXH better performer ahead so far this year.

Which ETF is attracting more investor money: XLVI or FTXH?

Year-to-date, the XLVI ETF saw +$4M in flows, compared to +$12M for FTXH.

Which ETF is bigger: XLVI or FTXH?

As of June 9, 2026, XLVI holds $14.84 M in assets under management (AUM), while FTXH manages $35.13 M.

What sectors do the XLVI and FTXH ETFs invest in?

XLVI leans toward sectors like Health Care. Meanwhile, FTXH focuses on Health Care.

What are the top holdings of the XLVI ETF and FTXH ETF?

XLVI top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. FTXH holds in its top three: BRISTOL-MYERS SQUIBB, JOHNSON&JOHNSON and MERCK & CO INC.

Which ETF is more diversified: XLVI or FTXH?

XLVI holds 58 securities with 70.39% of its assets in the top 15. FTXH has 47 securities and a top 15 weight of 69.57%.

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