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XHSvsWDNAETF Comparison

ETF 1

XHS

State Street SPDR S&P Health Care Services ETF

This fund is part of

US Health Care

-1.03%

Full XHS fund page

VS

ETF 2

WDNA

WisdomTree BioRevolution Fund

This fund is part of

BioTech & Genomics

+0.3%

Full WDNA fund page

State Street SPDR S&P Health Care Services ETF (XHS) belongs to the US Health Care segment. WisdomTree BioRevolution Fund (WDNA) is part of the BioTech & Genomics segment. XHS's top 3 sector exposures are Healthcare, Consumer Non-Cyclicals and Business Services. In contrast, WDNA's top sector exposures are Healthcare, Non-Energy Materials and Consumer Non-Cyclicals. XHS is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.45% for WDNA. XHS is up 32.24% year-to-date (YTD) with +$103M in YTD flows. WDNA performs better with 35.99% YTD performance, and +$1M in YTD flows. Run a side-by-side ETF comparison of XHS and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XHS vs WDNA performance and flow charts

Performance

Cumulative Flows

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Data Services

Historic performance and flows

Data as of 10/23/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	XHS WDNA	+5.46%-1.03%	+7.08%+15.90%	+32.24%+35.99%	+35.98%+37.79%	+78.28%+76.12%	+36.44%-3.55%
Flows	XHS WDNA	-$13M-	+$3M+$2M	+$103M+$1M	+$107M+$1M	+$74M+$1M	+$37M+$3M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	XHS WDNA	+17.05%+37.72%	+17.59%+27.98%	+18.30%+26.75%	+21.37%+26.07%
Max drawdown	XHS WDNA	-5.21%-8.13%	-11.97%-11.90%	-14.46%-36.45%	-29.93%-56.39%
Max drawdown duration	XHS WDNA	30d38d	121d147d	250d595d	1477d1815d

Trading data

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	XHS	WDNA
Last sale 10/23/2026 at 1:30 PM	$141.40	$23.05
Previous close 10/22/2026	$142.69	$23.18
Consolidated volume 10/22/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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	XHS	WDNA
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/23/2026 at 1:30 PM

Live

Closed

	XHS	WDNA
Last price	$141.40	$23.05
1D performance	-0.90%	-0.57%
AuM	$221.73 M	$4.60 M
E/R	0.35%	0.45%

Characteristics

	XHS	WDNA
Management strategy	Passive	Passive
Provider	State Street Investment Management	WisdomTree
Benchmark	S&P Health Care Services Select Industry Index	WisdomTree BioRevolution ESG Screened Index
N° of holdings	59	79
Asset class	Equities	Equities
Trailing 12m distribution yield	Join	Join
Inception date	September 28, 2011	June 3, 2021
ESG	No	Yes

More XHS data on Trackinsight

More WDNA data on Trackinsight

Exposure

Countries

XHS

USA

99.94%

Other

0.06%

WDNA

USA

84.99%

Other

15.01%

Sectors

XHS

Healthcare

95.16%

Other

4.84%

WDNA

Healthcare

90.16%

Other

9.84%

Diversification

XHS

Total weight of top 15 holdings out of 15

33.1%

WDNA

Total weight of top 15 holdings out of 15

44.42%

Top 15 holdings

Data as of August 31, 2026

XHS

Tenet Healthcare Corp.

2.65%

NeoGenomics, Inc.

2.60%

Lifestance Health Group, Inc.

2.58%

GeneDx Holdings Corp.

2.56%

Hinge Health, Inc.

2.45%

RadNet, Inc.

2.14%

Concentra Group Holdings Parent, Inc.

2.08%

Aveanna Healthcare Holdings, Inc.

2.07%

Labcorp Holdings, Inc.

2.03%

U.S. Physical Therapy, Inc.

2.03%

PACS Group, Inc.

2.02%

Addus HomeCare Corp.

2.02%

Guardant Health, Inc.

1.99%

Chemed Corp.

1.96%

Quest Diagnostics, Inc.

1.93%

WDNA

Moderna, Inc.

7.75%

Twist Bioscience Corp.

7.57%

Eli Lilly & Co.

3.53%

Johnson & Johnson

2.75%

Immunome, Inc.

2.67%

10X Genomics, Inc.

2.65%

Natera, Inc.

2.53%

Tempus AI, Inc.

2.35%

United Therapeutics Corp.

2.05%

Darling Ingredients, Inc.

1.93%

Stoke Therapeutics, Inc.

1.85%

Structure Therapeutics, Inc.

1.70%

Revolution Medicines, Inc.

1.70%

Corteva, Inc.

1.69%

CRISPR Therapeutics AG

1.68%

Frequently asked questions about XHS and WDNA

How have the XHS and WDNA ETFs performed in 2026?

As of October 23, 2026, XHS is up 32.24% year-to-date (YTD), while WDNA has returned 35.99%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: XHS or WDNA?

Year-to-date, the XHS ETF saw +$103M in flows, compared to +$1M for WDNA.

Which ETF is more volatile: XHS or WDNA?

Over the past year, XHS had a volatility of 17.59%, while WDNA experienced 27.98%.

Which ETF is bigger: XHS or WDNA?

As of October 23, 2026, XHS holds $221.73 M in assets under management (AUM), while WDNA manages $4.60 M.

What sectors do the XHS and WDNA ETFs invest in?

XHS leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.

What are the top holdings of the XHS ETF and WDNA ETF?

XHS top holdings include Tenet Healthcare Corp., NeoGenomics, Inc. and Lifestance Health Group, Inc.. WDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Eli Lilly & Co..

XHSvsWDNAETF Comparison

State Street SPDR S&P Health Care Services ETF

WisdomTree BioRevolution Fund

XHS vs WDNA performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the XHS and WDNA ETFs performed in 2026?

As of October 23, 2026, XHS is up 32.24% year-to-date (YTD), while WDNA has returned 35.99%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: XHS or WDNA?

Year-to-date, the XHS ETF saw +$103M in flows, compared to +$1M for WDNA.

Which ETF is more volatile: XHS or WDNA?

Over the past year, XHS had a volatility of 17.59%, while WDNA experienced 27.98%.

Which ETF is bigger: XHS or WDNA?

As of October 23, 2026, XHS holds $221.73 M in assets under management (AUM), while WDNA manages $4.60 M.

What sectors do the XHS and WDNA ETFs invest in?

XHS leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.

What are the top holdings of the XHS ETF and WDNA ETF?

XHS top holdings include Tenet Healthcare Corp., NeoGenomics, Inc. and Lifestance Health Group, Inc.. WDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Eli Lilly & Co..

Which ETF is more diversified: XHS or WDNA?

XHS holds 59 securities with 33.1% of its assets in the top 15. WDNA has 79 securities and a top 15 weight of 44.42%.

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