XHSvsPBEETF Comparison
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State Street SPDR S&P Health Care Services ETF (XHS) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XHS is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.58% for PBE. XHS is up 1.76% year-to-date (YTD) with +$9M in YTD flows. PBE performs worse with -2.66% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of XHS and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHS vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHS PBE | +7.11%+4.27% | -2.43%-3.98% | +1.76%-2.66% | +14.80%+32.11% | +21.34%+28.24% | -0.83%+3.38% |
| Flows | XHS PBE | +$1M+$2M | -$5M-$6M | +$9M-$2M | -$3M-$30M | -$30M-$58M | -$34M-$43M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHS PBE | +18.84%+19.57% | +17.87%+19.83% | +18.09%+20.15% | +21.14%+22.54% |
| Max drawdown | XHS PBE | -11.77%-9.36% | -12.54%-11.70% | -17.78%-22.21% | -32.53%-34.74% |
| Max drawdown duration | XHS PBE | 88d75d | 128d107d | 362d324d | 1761d1540d |
Trading data
XHS | PBE | |
Last sale 4/24/2026 at 7:59 PM | $108.86 | $79.88 |
| Previous close 04/24/2026 | $107.79 | $80.03 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XHS | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/24/2026 at 7:59 PM
Live
Closed
XHS | PBE | |
|---|---|---|
| Last price | $108.86 | $79.88 |
| 1D performance | +0.99% | -0.19% |
| AuM | $93.51 M | $249.88 M |
| E/R | 0.35% | 0.58% |
Characteristics
XHS | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Health Care Services Select Industry Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 51 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | September 28, 2011 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
XHS
USA
99.89%
Other
0.11%
PBE
USA
92.18%
Other
7.82%
Sectors
XHS
Health Care
86.56%
Other
13.44%
PBE
Health Care
97.59%
Other
2.41%
Diversification
XHS
Total weight of top 15 holdings out of 15
30.62%
PBE
Total weight of top 15 holdings out of 15
63.66%
Top 15 holdings
Data as of March 31, 2026
XHS
MEDNAX
2.18%
HEALTHEQUITY I/D
2.15%
GUARDANT HEALTH INC
2.12%
CORVEL
2.08%
US10950A1060
2.08%
CIGNA
2.06%
HUMANA
2.05%
ELEVANCE HEALTH INC
2.04%
DAVITA INC
2.00%
US5049221055
1.99%
ACADIA HEALTHCARE COMPANY
1.98%
CARDINAL HEALTH
1.98%
ALIGNMENT HEALTHCARE
1.98%
QUEST DIAGNOSTICS
1.97%
PROGYNY INC
1.96%
PBE
UTD THERAPEUT
6.05%
ILLUMINA
5.24%
REGENERON PHARMACEUTICALS
5.23%
ALNYLAM PHARMACEUTICALS
5.22%
BIOGEN INC
5.16%
AMGEN-T
4.99%
GILEAD SCIENCES
4.98%
INCYTE
4.89%
BIOCRYST PHARMACEUTICALS
3.66%
PROTAGONIST THERAPEUTICS INC
3.38%
TG THERAPEUTICS
3.11%
ROYALTY PHARMA
3.05%
NEUROCRINE BIOSCIENCES
2.93%
CATALYST PHARMACEUTICALS INC
2.89%
PTC THERAPEUTI/D
2.86%
Frequently asked questions about XHS and PBE
How have the XHS and PBE ETFs performed in 2026?
As of April 24, 2026, XHS is up 1.76% year-to-date (YTD), while PBE has lost -2.66%. That puts XHS better performer ahead so far this year.
Which ETF is attracting more investor money: XHS or PBE?
Year-to-date, the XHS ETF saw +$9M in flows, compared to -$2M for PBE.
Which ETF is more volatile: XHS or PBE?
Over the past year, XHS had a volatility of 17.87%, while PBE experienced 19.83%.
Which ETF is bigger: XHS or PBE?
As of April 24, 2026, XHS holds $93.51 M in assets under management (AUM), while PBE manages $249.88 M.
What sectors do the XHS and PBE ETFs invest in?
XHS leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.
What are the top holdings of the XHS ETF and PBE ETF?
XHS top holdings include MEDNAX, HEALTHEQUITY I/D and GUARDANT HEALTH INC. PBE holds in its top three: UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS.
Which ETF is more diversified: XHS or PBE?
XHS holds 58 securities with 30.62% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.66%.
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