XHSvsGNOMETF Comparison
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State Street SPDR S&P Health Care Services ETF (XHS) belongs to the US Health Care segment. Global X Genomics & Biotechnology ETF (GNOM) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XHS is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for GNOM. XHS is up 14.1% year-to-date (YTD) with +$13M in YTD flows. GNOM performs worse with 7.73% YTD performance, and +$4M in YTD flows. Run a side-by-side ETF comparison of XHS and GNOM below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHS vs GNOM performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/12/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHS GNOM | +7.30%+4.86% | +18.28%+12.44% | +14.10%+7.73% | +25.29%+47.34% | +34.73%-2.60% | +7.94%-46.66% |
| Flows | XHS GNOM | +$1M+$4M | +$8M+$6M | +$13M+$4M | +$79K-$4M | -$23M-$104M | -$74M+$8M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHS GNOM | +16.63%+31.23% | +17.99%+26.53% | +17.97%+28.94% | +21.22%+33.27% |
| Max drawdown | XHS GNOM | -5.61%-7.88% | -11.97%-18.16% | -17.78%-46.21% | -32.53%-72.17% |
| Max drawdown duration | XHS GNOM | 21d36d | 121d141d | 362d1095d | 1786d1807d |
Trading data
XHS | GNOM | |
Last sale 6/12/2026 at 1:30 PM | $122.08 | $48.95 |
| Previous close 06/11/2026 | $121.70 | $49.13 |
| Consolidated volume 06/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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XHS | GNOM | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/12/2026 at 1:30 PM
Live
Closed
XHS | GNOM | |
|---|---|---|
| Last price | $122.08 | $48.95 |
| 1D performance | +0.31% | -0.36% |
| AuM | $109.72 M | $59.59 M |
| E/R | 0.35% | 0.5% |
Characteristics
XHS | GNOM | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Global X |
| Benchmark | S&P Health Care Services Select Industry Index | Solactive Genomics Index |
| N° of holdings | 51 | 45 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | September 28, 2011 | April 5, 2019 |
| ESG | No | No |
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Exposure
Countries
XHS
USA
99.91%
Other
0.09%
GNOM
USA
88%
Other
12%
Sectors
XHS
Health Care
86.95%
Other
13.05%
GNOM
Health Care
88.52%
Other
11.48%
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Diversification
XHS
Total weight of top 15 holdings out of 15
33.75%
GNOM
Total weight of top 15 holdings out of 15
66.44%
Top 15 holdings
Data as of April 30, 2026
XHS
CENTENE
2.76%
HUMANA
2.55%
MOLINA HLTHCRE
2.44%
ELEVANCE HEALTH INC
2.39%
UNITEDHEALTH GRP
2.39%
ALIGNMENT HEALTHCARE
2.31%
CLOVER HEALTH INV CORP
2.28%
APOLLO MEDICAL HOLDINGS INC
2.25%
US10950A1060
2.14%
MEDNAX
2.10%
PRIVIA HEALTH GROUP
2.07%
CIGNA
2.05%
CVS HEALTH CORP
2.03%
CORVEL
2.00%
ACADIA HEALTHCARE COMPANY
2.00%
GNOM
MODERNA INC
7.59%
ARROWHEAD PHARMACEUTICALS INC
7.18%
US74006W2070
6.77%
ILLUMINA
5.19%
GUARDANT HEALTH INC
4.73%
BIOMARIN PHARMACEUTICAL
4.29%
VERTEX PHARMACEUTICALS
4.16%
NATERA
4.14%
BIONTECH SE ADR
4.03%
BIO-TECHNE CORP
3.44%
CRISPR THERAPEUTICS
3.32%
TWIST BIOSCIENCE CORP
3.14%
LEGEND BIOTECH
2.91%
NL0015002SN0
2.77%
BRISTOL-MYERS SQUIBB
2.77%
Frequently asked questions about XHS and GNOM
How have the XHS and GNOM ETFs performed in 2026?
As of June 12, 2026, XHS is up 14.1% year-to-date (YTD), while GNOM has returned 7.73%. That puts XHS better performer ahead so far this year.
Which ETF is attracting more investor money: XHS or GNOM?
Year-to-date, the XHS ETF saw +$13M in flows, compared to +$4M for GNOM.
Which ETF is more volatile: XHS or GNOM?
Over the past year, XHS had a volatility of 17.99%, while GNOM experienced 26.53%.
Which ETF is bigger: XHS or GNOM?
As of June 12, 2026, XHS holds $109.72 M in assets under management (AUM), while GNOM manages $59.59 M.
What sectors do the XHS and GNOM ETFs invest in?
XHS leans toward sectors like Health Care. Meanwhile, GNOM focuses on Health Care.
What are the top holdings of the XHS ETF and GNOM ETF?
XHS top holdings include CENTENE, HUMANA and MOLINA HLTHCRE. GNOM holds in its top three: MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070.
Which ETF is more diversified: XHS or GNOM?
XHS holds 58 securities with 33.75% of its assets in the top 15. GNOM has 49 securities and a top 15 weight of 66.44%.
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