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XHEvsWDNAETF Comparison

ETF 1

XHE

State Street SPDR S&P Health Care Equipment ETF

This fund is part of

US Health Care

+0.41%

Full XHE fund page

VS

ETF 2

WDNA

WisdomTree BioRevolution Fund

This fund is part of

BioTech & Genomics

+4.79%

Full WDNA fund page

State Street SPDR S&P Health Care Equipment ETF (XHE) belongs to the US Health Care segment. WisdomTree BioRevolution Fund (WDNA) is part of the BioTech & Genomics segment. XHE's top 2 sector exposures are Healthcare and Finance. In contrast, WDNA's top sector exposures are Healthcare, Non-Energy Materials and Consumer Non-Cyclicals. XHE is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.45% for WDNA. XHE is up 5.71% year-to-date (YTD) with -$9M in YTD flows. WDNA performs better with 41.34% YTD performance, and +$1M in YTD flows. Run a side-by-side ETF comparison of XHE and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XHE vs WDNA performance and flow charts

Performance

Cumulative Flows

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Data Services

Historic performance and flows

Data as of 10/27/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	XHE WDNA	+1.69%+0.26%	+6.51%+21.85%	+5.71%+41.34%	+13.97%+43.47%	+39.19%+89.33%	-24.85%+1.89%
Flows	XHE WDNA	-$40M+$239K	-$10M+$2M	-$9M+$1M	-$12M+$1M	-$223M+$1M	-$399M+$3M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	XHE WDNA	+20.36%+38.04%	+22.70%+28.13%	+21.88%+26.75%	+24.86%+26.10%
Max drawdown	XHE WDNA	-9.09%-8.13%	-18.20%-11.90%	-24.35%-36.45%	-49.37%-56.39%
Max drawdown duration	XHE WDNA	69d38d	207d147d	565d595d	1819d1819d

Trading data

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	XHE	WDNA
Last sale 10/27/2026 at 1:30 PM	$93.25	$23.96
Previous close 10/27/2026	$93.09	$23.18
Consolidated volume 10/27/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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	XHE	WDNA
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/27/2026 at 1:30 PM

Live

Closed

	XHE	WDNA
Last price	$93.25	$23.96
1D performance	+0.17%	+3.40%
AuM	$153.71 M	$5.02 M
E/R	0.35%	0.45%

Characteristics

	XHE	WDNA
Management strategy	Passive	Passive
Provider	State Street Investment Management	WisdomTree
Benchmark	S&P Health Care Equipment Select Industry Index	WisdomTree BioRevolution ESG Screened Index
N° of holdings	67	79
Asset class	Equities	Equities
Trailing 12m distribution yield	Join	Join
Inception date	January 26, 2011	June 3, 2021
ESG	No	Yes

More XHE data on Trackinsight

More WDNA data on Trackinsight

Exposure

Countries

XHE

USA

93.57%

Other

6.43%

WDNA

USA

84.99%

Other

15.01%

Sectors

XHE

Healthcare

97.47%

Other

2.53%

WDNA

Healthcare

90.16%

Other

9.84%

Diversification

XHE

Total weight of top 15 holdings out of 15

30.96%

WDNA

Total weight of top 15 holdings out of 15

44.42%

Top 15 holdings

Data as of August 31, 2026

XHE

AtriCure, Inc.

2.59%

Strive, Inc. (United States)

2.47%

Inspire Medical Systems, Inc.

2.19%

Glaukos Corp.

2.16%

Butterfly Network, Inc.

2.15%

CONMED Corp.

2.02%

Integer Holdings Corp.

2.02%

Tandem Diabetes Care, Inc.

2.00%

Merit Medical Systems, Inc.

1.99%

Artivion, Inc.

1.94%

Haemonetics Corp.

1.93%

UFP Technologies, Inc.

1.89%

Baxter International, Inc.

1.88%

Becton, Dickinson & Co.

1.87%

Neogen Corp.

1.86%

WDNA

Moderna, Inc.

7.75%

Twist Bioscience Corp.

7.57%

Eli Lilly & Co.

3.53%

Johnson & Johnson

2.75%

Immunome, Inc.

2.67%

10X Genomics, Inc.

2.65%

Natera, Inc.

2.53%

Tempus AI, Inc.

2.35%

United Therapeutics Corp.

2.05%

Darling Ingredients, Inc.

1.93%

Stoke Therapeutics, Inc.

1.85%

Structure Therapeutics, Inc.

1.70%

Revolution Medicines, Inc.

1.70%

Corteva, Inc.

1.69%

CRISPR Therapeutics AG

1.68%

Frequently asked questions about XHE and WDNA

How have the XHE and WDNA ETFs performed in 2026?

As of October 27, 2026, XHE is up 5.71% year-to-date (YTD), while WDNA has returned 41.34%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: XHE or WDNA?

Year-to-date, the XHE ETF saw -$9M in flows, compared to +$1M for WDNA.

Which ETF is more volatile: XHE or WDNA?

Over the past year, XHE had a volatility of 22.7%, while WDNA experienced 28.13%.

Which ETF is bigger: XHE or WDNA?

As of October 27, 2026, XHE holds $153.71 M in assets under management (AUM), while WDNA manages $5.02 M.

What sectors do the XHE and WDNA ETFs invest in?

XHE leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.

What are the top holdings of the XHE ETF and WDNA ETF?

XHE top holdings include AtriCure, Inc., Strive, Inc. (United States) and Inspire Medical Systems, Inc.. WDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Eli Lilly & Co..

XHEvsWDNAETF Comparison

State Street SPDR S&P Health Care Equipment ETF

WisdomTree BioRevolution Fund

XHE vs WDNA performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the XHE and WDNA ETFs performed in 2026?

As of October 27, 2026, XHE is up 5.71% year-to-date (YTD), while WDNA has returned 41.34%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: XHE or WDNA?

Year-to-date, the XHE ETF saw -$9M in flows, compared to +$1M for WDNA.

Which ETF is more volatile: XHE or WDNA?

Over the past year, XHE had a volatility of 22.7%, while WDNA experienced 28.13%.

Which ETF is bigger: XHE or WDNA?

As of October 27, 2026, XHE holds $153.71 M in assets under management (AUM), while WDNA manages $5.02 M.

What sectors do the XHE and WDNA ETFs invest in?

XHE leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.

What are the top holdings of the XHE ETF and WDNA ETF?

XHE top holdings include AtriCure, Inc., Strive, Inc. (United States) and Inspire Medical Systems, Inc.. WDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Eli Lilly & Co..

Which ETF is more diversified: XHE or WDNA?

XHE holds 67 securities with 30.96% of its assets in the top 15. WDNA has 79 securities and a top 15 weight of 44.42%.

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