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XHEvsGNOMETF Comparison

ETF 1

XHE

State Street SPDR S&P Health Care Equipment ETF

This fund is part of

US Health Care

+0.32%

Full XHE fund page

VS

ETF 2

GNOM

Global X Genomics & Biotechnology ETF

This fund is part of

BioTech & Genomics

-2.11%

Full GNOM fund page

State Street SPDR S&P Health Care Equipment ETF (XHE) belongs to the US Health Care segment. Global X Genomics & Biotechnology ETF (GNOM) is part of the BioTech & Genomics segment. XHE's top 3 sector exposures are Healthcare and Finance. In contrast, GNOM's top sector exposures are Healthcare and Industrials. XHE is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for GNOM. XHE is down -3.04% year-to-date (YTD) with +$2M in YTD flows. GNOM performs better with 18.8% YTD performance, and +$18M in YTD flows. Run a side-by-side ETF comparison of XHE and GNOM below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XHE vs GNOM performance and flow charts

Performance

Cumulative Flows

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Data Services

Historic performance and flows

Data as of 07/24/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	XHE GNOM	+3.29%+0.87%	+3.26%+17.93%	-3.04%+18.80%	+8.72%+51.85%	-12.17%+12.37%	-31.68%-38.62%
Flows	XHE GNOM	+$2M+$14M	+$26M+$19M	+$2M+$18M	-$18M+$13M	-$379M-$95M	-$397M-$862K

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	XHE GNOM	+26.19%+28.84%	+22.63%+26.67%	+22.18%+29.09%	+24.70%+33.32%
Max drawdown	XHE GNOM	-6.40%-8.57%	-18.20%-18.16%	-32.21%-43.23%	-49.90%-72.01%
Max drawdown duration	XHE GNOM	43d18d	197d145d	1094d905d	1786d1786d

Trading data

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	XHE	GNOM
Last sale 7/27/2026 at 1:30 PM	$87.54	$53.69
Previous close 07/24/2026	$85.18	$53.99
Consolidated volume 07/24/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of June 30, 2026

1-year trailing difference

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	XHE	GNOM
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 7/27/2026 at 1:30 PM

Live

Closed

	XHE	GNOM
Last price	$87.54	$53.69
1D performance	+2.77%	-0.55%
AuM	$151.67 M	$79.16 M
E/R	0.35%	0.5%

Characteristics

	XHE	GNOM
Management strategy	Passive	Passive
Provider	State Street Investment Management	Global X
Benchmark	S&P Health Care Equipment Select Industry Index	Solactive Genomics Index
N° of holdings	67	50
Asset class	Equities	Equities
Trailing 12m distribution yield	Join	Join
Inception date	January 26, 2011	April 5, 2019
ESG	No	No

More XHE data on Trackinsight

More GNOM data on Trackinsight

Exposure

Countries

XHE

USA

89.54%

Other

10.46%

GNOM

USA

84.1%

Other

15.9%

Sectors

XHE

Healthcare

94.54%

Other

5.46%

GNOM

Healthcare

99.75%

Other

0.25%

Diversification

XHE

Total weight of top 15 holdings out of 15

26.73%

GNOM

Total weight of top 15 holdings out of 15

61.22%

Top 15 holdings

Data as of June 30, 2026

XHE

Butterfly Network, Inc.

2.45%

QuidelOrtho Corp.

2.04%

Glaukos Corp.

1.79%

UFP Technologies, Inc.

1.79%

Axogen, Inc.

1.76%

Lantheus Holdings, Inc.

1.74%

Artivion, Inc.

1.73%

Envista Holdings Corp.

1.72%

Omnicell, Inc.

1.71%

Medline, Inc.

1.69%

Alphatec Holdings, Inc.

1.67%

Dentsply Sirona, Inc.

1.66%

Inspire Medical Systems, Inc.

1.66%

The Cooper Cos., Inc.

1.66%

Edwards Lifesciences Corp.

1.65%

GNOM

Guardant Health, Inc.

5.78%

Twist Bioscience Corp.

5.09%

Illumina, Inc.

4.67%

Natera, Inc.

4.41%

Moderna, Inc.

4.22%

Veracyte, Inc.

4.12%

Bio-Techne Corp.

4.08%

Vertex Pharmaceuticals, Inc.

3.85%

Legend Biotech Corp.

3.82%

10X Genomics, Inc.

3.70%

Arrowhead Pharmaceuticals, Inc.

3.67%

BioMarin Pharmaceutical, Inc.

3.59%

Praxis Precision Medicines, Inc.

3.50%

CRISPR Therapeutics AG

3.36%

QIAGEN NV

3.35%

Frequently asked questions about XHE and GNOM

How have the XHE and GNOM ETFs performed in 2026?

As of July 24, 2026, XHE is down -3.04% year-to-date (YTD), while GNOM has returned 18.8%. That puts GNOM better performer ahead so far this year.

Which ETF is attracting more investor money: XHE or GNOM?

Year-to-date, the XHE ETF saw +$2M in flows, compared to +$18M for GNOM.

Which ETF is more volatile: XHE or GNOM?

Over the past year, XHE had a volatility of 22.63%, while GNOM experienced 26.67%.

Which ETF is bigger: XHE or GNOM?

As of July 24, 2026, XHE holds $151.67 M in assets under management (AUM), while GNOM manages $79.16 M.

What sectors do the XHE and GNOM ETFs invest in?

XHE leans toward sectors like Healthcare. Meanwhile, GNOM focuses on Healthcare.

What are the top holdings of the XHE ETF and GNOM ETF?

XHE top holdings include Butterfly Network, Inc., QuidelOrtho Corp. and Glaukos Corp.. GNOM holds in its top three: Guardant Health, Inc., Twist Bioscience Corp. and Illumina, Inc..

XHEvsGNOMETF Comparison

State Street SPDR S&P Health Care Equipment ETF

Global X Genomics & Biotechnology ETF

XHE vs GNOM performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the XHE and GNOM ETFs performed in 2026?

As of July 24, 2026, XHE is down -3.04% year-to-date (YTD), while GNOM has returned 18.8%. That puts GNOM better performer ahead so far this year.

Which ETF is attracting more investor money: XHE or GNOM?

Year-to-date, the XHE ETF saw +$2M in flows, compared to +$18M for GNOM.

Which ETF is more volatile: XHE or GNOM?

Over the past year, XHE had a volatility of 22.63%, while GNOM experienced 26.67%.

Which ETF is bigger: XHE or GNOM?

As of July 24, 2026, XHE holds $151.67 M in assets under management (AUM), while GNOM manages $79.16 M.

What sectors do the XHE and GNOM ETFs invest in?

XHE leans toward sectors like Healthcare. Meanwhile, GNOM focuses on Healthcare.

What are the top holdings of the XHE ETF and GNOM ETF?

XHE top holdings include Butterfly Network, Inc., QuidelOrtho Corp. and Glaukos Corp.. GNOM holds in its top three: Guardant Health, Inc., Twist Bioscience Corp. and Illumina, Inc..

Which ETF is more diversified: XHE or GNOM?

XHE holds 67 securities with 26.73% of its assets in the top 15. GNOM has 50 securities and a top 15 weight of 61.22%.

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