XHEvsGNOMETF Comparison
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State Street SPDR S&P Health Care Equipment ETF (XHE) belongs to the US Health Care segment. Global X Genomics & Biotechnology ETF - USD (GNOM) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XHE is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for GNOM. XHE is down -6.1% year-to-date (YTD) with -$6M in YTD flows. GNOM performs better with 0.74% YTD performance, and -$602K in YTD flows. Run a side-by-side ETF comparison of XHE and GNOM below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHE vs GNOM performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHE GNOM | +4.44%+7.67% | -6.33%-7.03% | -6.10%+0.74% | +4.10%+41.51% | -16.38%-6.56% | -34.81%-50.60% |
| Flows | XHE GNOM | +$345K-$829K | -$4M+$1M | -$6M-$602K | -$35M-$14M | -$282M-$120M | -$404M+$1M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHE GNOM | +23.06%+28.47% | +21.27%+27.16% | +21.32%+28.79% | +24.31%+33.22% |
| Max drawdown | XHE GNOM | -14.31%-16.08% | -18.20%-18.16% | -32.60%-46.50% | -49.90%-72.17% |
| Max drawdown duration | XHE GNOM | 57d88d | 106d92d | 1096d1075d | 1695d1758d |
Trading data
XHE | GNOM | |
Last sale 4/27/2026 at 1:30 PM | $82.67 | $45.55 |
| Previous close 04/24/2026 | $82.71 | $45.97 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XHE | GNOM | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/27/2026 at 1:30 PM
Live
Closed
XHE | GNOM | |
|---|---|---|
| Last price | $82.67 | $45.55 |
| 1D performance | -0.05% | -0.92% |
| AuM | $138.61 M | $51.60 M |
| E/R | 0.35% | 0.5% |
Characteristics
XHE | GNOM | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Global X |
| Benchmark | S&P Health Care Equipment Select Industry Index | Solactive Genomics Index |
| N° of holdings | 61 | 45 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 26, 2011 | April 5, 2019 |
| ESG | No | No |
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Exposure
Countries
XHE
USA
92.19%
Other
7.81%
GNOM
USA
87.57%
Other
12.43%
Sectors
XHE
Health Care
89.87%
Other
10.13%
GNOM
Health Care
88.49%
Other
11.51%
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Diversification
XHE
Total weight of top 15 holdings out of 15
26.74%
GNOM
Total weight of top 15 holdings out of 15
66.21%
Top 15 holdings
Data as of March 31, 2026
XHE
TELEFLEX
1.86%
STAAR SURGICAL
1.84%
BUTTERFLY NETWORK INC
1.84%
US58507V1070
1.83%
GLAUKOS
1.82%
INTEGER HOLDINGS
1.79%
AXOGEN
1.79%
LIVANOVA
1.78%
MASIMO
1.76%
LEMAITRE VASCULAR
1.75%
ARTIVION INC
1.75%
HOLOGIC
1.74%
STERIS
1.74%
GLOBUS MEDICAL
1.72%
IRHYTHM TECHNOLOGIES
1.72%
GNOM
MODERNA INC
8.48%
ARROWHEAD PHARMACEUTICALS INC
6.21%
US74006W2070
6.13%
ILLUMINA
5.52%
GUARDANT HEALTH INC
5.18%
VERTEX PHARMACEUTICALS
4.61%
BIOMARIN PHARMACEUTICAL
4.59%
NATERA
4.21%
BIO-TECHNE CORP
3.64%
BIONTECH SE ADR
3.58%
CRISPR THERAPEUTICS
3.08%
BRISTOL-MYERS SQUIBB
3.05%
ALNYLAM PHARMACEUTICALS
2.85%
TWIST BIOSCIENCE CORP
2.54%
ASTRAZENECA
2.53%
Frequently asked questions about XHE and GNOM
How have the XHE and GNOM ETFs performed in 2026?
As of April 24, 2026, XHE is down -6.1% year-to-date (YTD), while GNOM has returned 0.74%. That puts GNOM better performer ahead so far this year.
Which ETF is attracting more investor money: XHE or GNOM?
Year-to-date, the XHE ETF saw -$6M in flows, compared to -$602K for GNOM.
Which ETF is more volatile: XHE or GNOM?
Over the past year, XHE had a volatility of 21.27%, while GNOM experienced 27.16%.
Which ETF is bigger: XHE or GNOM?
As of April 24, 2026, XHE holds $138.61 M in assets under management (AUM), while GNOM manages $51.60 M.
What sectors do the XHE and GNOM ETFs invest in?
XHE leans toward sectors like Health Care. Meanwhile, GNOM focuses on Health Care.
What are the top holdings of the XHE ETF and GNOM ETF?
XHE top holdings include TELEFLEX, STAAR SURGICAL and BUTTERFLY NETWORK INC. GNOM holds in its top three: MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070.
Which ETF is more diversified: XHE or GNOM?
XHE holds 67 securities with 26.74% of its assets in the top 15. GNOM has 47 securities and a top 15 weight of 66.21%.
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