BROUGHT TO YOU BY:

ETF Portfolio Builder

New

ETF Portfolio Builder

New

WDNAvsHELXETF Comparison

ETF 1

WDNA

WisdomTree BioRevolution Fund

This fund is part of

BioTech & Genomics

-0.12%

Full WDNA fund page

VS

ETF 2

HELX

Franklin Genomic Advancements ETF

This fund is part of

BioTech & Genomics

-0.12%

Full HELX fund page

WisdomTree BioRevolution Fund (WDNA) and Franklin Genomic Advancements ETF (HELX) belong to the same industry segment: BioTech & Genomics. WDNA's top 3 sector exposures are Health Care, Materials and Consumer Staples. In contrast, HELX's top sector exposures are Health Care, Materials and Information Technology. WDNA is less expensive with a Total Expense Ratio (TER) of 0.45%, versus 0.5% for HELX. WDNA is up 4.41% year-to-date (YTD) with -$357K in YTD flows. HELX performs worse with -7.26% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of WDNA and HELX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

Find out how industry players manage ETF portfolios. Discover our library of Model portfolios

WDNA vs HELX performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 04/27/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	WDNA HELX	+5.78%+7.65%	-4.95%-10.35%	+4.41%-7.26%	+41.36%+24.49%	+11.54%+14.46%	n/a-29.14%
Flows	WDNA HELX	--	-$357K-	-$357K+$2M	-$357K+$8M	-$524K+$9M	-+$14M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	WDNA HELX	+24.01%+24.87%	+26.79%+20.84%	+24.80%+20.22%	n/a+23.68%
Max drawdown	WDNA HELX	-10.14%-16.72%	-11.90%-17.89%	-37.80%-29.16%	n/a-58.50%
Max drawdown duration	WDNA HELX	79d90d	95d148d	901d458d	n/a1693d

Trading data

Create an account to view trading data

Join for free

	WDNA	HELX
Last sale 4/28/2026 at 1:30 PM	$17.65	$33.13
Previous close 04/27/2026	$17.70	$33.63
Consolidated volume 04/27/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of April 29, 2026

1-year trailing difference

Create an account to view replication metrics

Join for free

HELX

is actively managed and doesn’t replicate an index

Create an account to view replication quality

Join for free

	WDNA	HELX
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 4/28/2026 at 1:30 PM

Live

Closed

	WDNA	HELX
Last price	$17.65	$33.13
1D performance	-0.28%	-1.49%
AuM	$2.30 M	$21.87 M
E/R	0.45%	0.5%

Characteristics

	WDNA	HELX
Management strategy	Passive	Active
Provider	WisdomTree	Franklin Templeton
Benchmark	WisdomTree BioRevolution Index	-
N° of holdings	75	51
Asset class	Equities	-
Trailing 12m distribution yield	Join	Join
Inception date	June 3, 2021	February 25, 2020
ESG	No	No

More WDNA data on Trackinsight

More HELX data on Trackinsight

Exposure

Countries

WDNA

USA

80.59%

Other

19.41%

HELX

USA

87.6%

Other

12.4%

Sectors

WDNA

Health Care

82.52%

Other

17.48%

HELX

Health Care

89.74%

Other

10.26%

Diversification

WDNA

Total weight of top 15 holdings out of 15

38.65%

HELX

Total weight of top 15 holdings out of 15

60.42%

Top 15 holdings

Data as of March 31, 2026

WDNA

MODERNA INC

4.49%

JOHNSON&JOHNSON

3.26%

UTD THERAPEUT

2.90%

PFIZER

2.82%

LILLY

2.65%

STOKE THERAPEUTICS INC

2.57%

NATERA

2.46%

AMGEN-T

2.43%

ASTRAZENECA

2.34%

AMICUS THERAPEUTICS

2.28%

TWIST BIOSCIENCE CORP

2.20%

BIONTECH SE ADR

2.09%

US86366E1064

2.09%

IONIS PHARMACEUTICALS INC

2.07%

GILEAD SCIENCES

2.00%

HELX

NATERA

6.89%

GUARDANT HEALTH INC

6.82%

KRYSTAL BIOTECH INC

5.46%

UTD THERAPEUT

4.40%

BRIDGEBIO PHARMA

4.36%

INSMED

4.31%

LIGAND PHARMACEUTICALS

3.80%

SAMSUNG BIOLOGICS CO LTD

3.37%

ADAPTIVE BIOTECHNOLOGIES

3.32%

ASTRAZENECA

3.24%

VERTEX PHARMACEUTICALS

3.20%

MEDPACE HOLDINGS INC

3.05%

CORTEVA INC

2.81%

ALNYLAM PHARMACEUTICALS

2.71%

REGENERON PHARMACEUTICALS

2.67%

Frequently asked questions about WDNA and HELX

How have the WDNA and HELX ETFs performed in 2026?

As of April 27, 2026, WDNA is up 4.41% year-to-date (YTD), while HELX has lost -7.26%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: WDNA or HELX?

Year-to-date, the WDNA ETF saw -$357K in flows, compared to +$2M for HELX.

Which ETF is more volatile: WDNA or HELX?

Over the past year, WDNA had a volatility of 26.79%, while HELX experienced 20.84%.

Which ETF is bigger: WDNA or HELX?

As of April 27, 2026, WDNA holds $2.30 M in assets under management (AUM), while HELX manages $21.87 M.

What sectors do the WDNA and HELX ETFs invest in?

WDNA leans toward sectors like Health Care. Meanwhile, HELX focuses on Health Care.

What are the top holdings of the WDNA ETF and HELX ETF?

WDNA top holdings include MODERNA INC, JOHNSON&JOHNSON and UTD THERAPEUT. HELX holds in its top three: NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC.

WDNAvsHELXETF Comparison

WisdomTree BioRevolution Fund

Franklin Genomic Advancements ETF

WDNA vs HELX performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the WDNA and HELX ETFs performed in 2026?

As of April 27, 2026, WDNA is up 4.41% year-to-date (YTD), while HELX has lost -7.26%. That puts WDNA better performer ahead so far this year.

Which ETF is attracting more investor money: WDNA or HELX?

Year-to-date, the WDNA ETF saw -$357K in flows, compared to +$2M for HELX.

Which ETF is more volatile: WDNA or HELX?

Over the past year, WDNA had a volatility of 26.79%, while HELX experienced 20.84%.

Which ETF is bigger: WDNA or HELX?

As of April 27, 2026, WDNA holds $2.30 M in assets under management (AUM), while HELX manages $21.87 M.

What sectors do the WDNA and HELX ETFs invest in?

WDNA leans toward sectors like Health Care. Meanwhile, HELX focuses on Health Care.

What are the top holdings of the WDNA ETF and HELX ETF?

WDNA top holdings include MODERNA INC, JOHNSON&JOHNSON and UTD THERAPEUT. HELX holds in its top three: NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC.

Which ETF is more diversified: WDNA or HELX?

WDNA holds 84 securities with 38.65% of its assets in the top 15. HELX has 60 securities and a top 15 weight of 60.42%.

Calamos Investments Powers the Next Phase of the Autocallable Revolution