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TMEDvsXLVIETF Comparison

ETF 1
TMED

T. Rowe Price Health Care ETF

This fund is part of
US Health Care
-0%
VS
ETF 2
XLVI

State Street Health Care Select Sector SPDR Premium Income Fund

This fund is part of
Options Strategies
+0.4%

T. Rowe Price Health Care ETF (TMED) belongs to the US Health Care segment. State Street Health Care Select Sector SPDR Premium Income Fund (XLVI) is part of the Options Strategies segment. TMED's top 3 sector exposures are Health Care and Financials. In contrast, XLVI's top sector exposures are Health Care  TMED is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.35% for XLVI. TMED is up 6.93% year-to-date (YTD) with +$4M in YTD flows. XLVI performs worse with 2.27% YTD performance, and +$4M in YTD flows. Run a side-by-side ETF comparison of TMED and XLVI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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TMED vs XLVI performance and flow charts

Performance

0.02.04.06.0%May 11May 18May 25Jun 1Jun 8

Cumulative Flows

0 M0.5 M1 M1.5 M2 MMay 11May 18May 25Jun 1Jun 8

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 06/11/2026
1M3MYTD1Y3Y5Y
Perf.
TMED
XLVI
+5.32%+4.57%
+7.29%+3.73%
+6.93%+2.27%
+27.94%n/a
n/an/a
n/an/a
Flows
TMED
XLVI
+$2M+$2M
+$2M+$2M
+$4M+$4M
+$18M-
--
--
Volatility and drawdown
3M1Y3Y5Y
Volatility
TMED
XLVI
+21.78%+13.13%
+18.19%n/a
n/an/a
n/an/a
Max drawdown
TMED
XLVI
-6.52%-4.28%
-11.09%n/a
n/an/a
n/an/a
Max drawdown duration
TMED
XLVI
27d65d
125dn/a
n/an/a
n/an/a
Trading data

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TMED
XLVI
Last sale
6/12/2026 at 1:30 PM
$31.72
$25.64
Previous close
06/11/2026
$31.77
$25.60
Consolidated volume
06/11/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
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Main metrics
Last update 6/12/2026 at 1:30 PM
Live
Closed
TMED
XLVI
Last price
$31.72
$25.64
1D performance
-0.15%
+0.14%
AuM$22.22 M$15.12 M
E/R0.44%0.35%
Characteristics
TMED
XLVI
Management strategyActiveActive
ProviderT. Rowe PriceState Street Investment Management
Benchmark--
N° of holdings7455
Asset class--
Trailing 12m distribution yield
Join
Join
Inception dateJune 11, 2025July 30, 2025
ESGNoNo
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Exposure

Countries

TMED
USA
85.53%
Other
14.47%
XLVI
USA
96.67%
Other
3.33%

Sectors

TMED
Health Care
87.36%
Other
12.64%
XLVI
Health Care
97.69%
Other
2.31%
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Diversification

TMED

Total weight of top 15 holdings out of 15

53.6%
XLVI

Total weight of top 15 holdings out of 15

70.39%

Top 15 holdings

Data as of April 30, 2026
TMED
LILLY
14.29%
UNITEDHEALTH GRP
8.22%
GILEAD SCIENCES
4.61%
THERMO FISHER SCIENTIFIC
4.23%
ABBOTT LABS
3.82%
DANAHER
2.60%
STRYKER
2.08%
HUMANA
1.91%
DYNE THERAPEUTICS INC
1.79%
ALNYLAM PHARMACEUTICALS
1.75%
WEST PHARM SVCS
1.75%
BOSTON SCIENTIFIC
1.72%
WATERS
1.64%
AGILENT TECHNOLOGIES
1.63%
MEDTRONIC PLC
1.56%
XLVI
LILLY
13.98%
JOHNSON&JOHNSON
10.46%
ABBVIE
7.05%
UNITEDHEALTH GRP
6.34%
MERCK & CO INC
5.12%
AMGEN-T
3.52%
THERMO FISHER SCIENTIFIC
3.40%
INTUITIVE SURGICAL
3.07%
GILEAD SCIENCES
3.06%
ABBOTT LABS
2.98%
PFIZER
2.87%
BRISTOL-MYERS SQUIBB
2.33%
DANAHER
2.13%
VERTEX PHARMACEUTICALS
2.05%
STRYKER
2.05%
Frequently asked questions about TMED and XLVI

How have the TMED and XLVI ETFs performed in 2026?

As of June 11, 2026, TMED is up 6.93% year-to-date (YTD), while XLVI has returned 2.27%. That puts TMED better performer ahead so far this year.

Which ETF is attracting more investor money: TMED or XLVI?

Year-to-date, the TMED ETF saw +$4M in flows, compared to +$4M for XLVI.

Which ETF is bigger: TMED or XLVI?

As of June 11, 2026, TMED holds $22.22 M in assets under management (AUM), while XLVI manages $15.12 M.

What sectors do the TMED and XLVI ETFs invest in?

TMED leans toward sectors like Health Care. Meanwhile, XLVI focuses on Health Care.

What are the top holdings of the TMED ETF and XLVI ETF?

TMED top holdings include LILLY, UNITEDHEALTH GRP and GILEAD SCIENCES. XLVI holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.

Which ETF is more diversified: TMED or XLVI?

TMED holds 79 securities with 53.6% of its assets in the top 15. XLVI has 58 securities and a top 15 weight of 70.39%.

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