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TMEDvsPBEETF Comparison

ETF 1

TMED

T. Rowe Price Health Care ETF

This fund is part of

US Health Care

-1.03%

Full TMED fund page

VS

ETF 2

PBE

Invesco Dynamic Biotechnology & Genome ETF

This fund is part of

BioTech & Genomics

+0.3%

Full PBE fund page

T. Rowe Price Health Care ETF (TMED) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. TMED's top 3 sector exposures are Healthcare, Consumer Non-Cyclicals and Non-Corporate. In contrast, PBE's top sector exposures are Healthcare. TMED is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.59% for PBE. TMED is up 16.23% year-to-date (YTD) with +$15M in YTD flows. PBE performs better with 21.44% YTD performance, and +$113M in YTD flows. Run a side-by-side ETF comparison of TMED and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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TMED vs PBE performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 10/22/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	TMED PBE	-0.47%+2.54%	+2.02%+9.63%	+16.23%+21.44%	+21.78%+36.89%	n/a+84.49%	n/a+33.87%
Flows	TMED PBE	+$2M-$947K	+$10M+$111M	+$15M+$113M	+$16M+$115M	-+$62M	-+$65M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	TMED PBE	+19.33%+21.41%	+18.68%+19.97%	n/a+20.69%	n/a+22.69%
Max drawdown	TMED PBE	-10.10%-5.97%	-11.09%-11.70%	n/a-22.21%	n/a-32.63%
Max drawdown duration	TMED PBE	64d46d	125d166d	n/a324d	n/a1468d

Trading data

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	TMED	PBE
Last sale 10/23/2026 at 1:30 PM	$34.08	$98.72
Previous close 10/22/2026	$34.49	$99.38
Consolidated volume 10/22/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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TMED

is actively managed and doesn’t replicate an index

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	TMED	PBE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/23/2026 at 1:30 PM

Live

Closed

	TMED	PBE
Last price	$34.08	$98.72
1D performance	-1.20%	-0.66%
AuM	$34.50 M	$429.04 M
E/R	0.44%	0.59%

Characteristics

	TMED	PBE
Management strategy	Active	Passive
Provider	T. Rowe Price	Invesco
Benchmark	-	Dynamic Biotech & Genome Intellidex Index
N° of holdings	106	30
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	June 11, 2025	June 23, 2005
ESG	No	No

More TMED data on Trackinsight

More PBE data on Trackinsight

Exposure

Countries

TMED

USA

92.86%

Other

7.14%

PBE

USA

97.22%

Other

2.78%

Sectors

TMED

Healthcare

98.26%

Other

1.74%

PBE

Healthcare

100%

Other

0%

Diversification

TMED

Total weight of top 15 holdings out of 15

56.93%

PBE

Total weight of top 15 holdings out of 15

63.67%

Top 15 holdings

Data as of August 31, 2026

TMED

Eli Lilly & Co.

13.87%

UnitedHealth Group, Inc.

5.32%

Alnylam Pharmaceuticals, Inc.

5.20%

Thermo Fisher Scientific, Inc.

3.74%

Cencora, Inc.

3.65%

Insulet Corp.

3.23%

Gilead Sciences, Inc.

2.99%

Agilent Technologies, Inc.

2.85%

Elanco Animal Health, Inc.

2.63%

Dyne Therapeutics, Inc.

2.47%

Boston Scientific Corp.

2.25%

Stryker Corp.

2.21%

Danaher Corp.

2.20%

Waters Corp.

2.17%

West Pharmaceutical Services, Inc.

2.16%

PBE

CareDx, Inc.

5.49%

Amgen, Inc.

5.38%

Regeneron Pharmaceuticals, Inc.

5.26%

Vertex Pharmaceuticals, Inc.

5.21%

Royalty Pharma Plc

4.76%

Biogen, Inc.

4.75%

Gilead Sciences, Inc.

4.61%

United Therapeutics Corp.

3.77%

Omeros Corp.

3.73%

Repligen Corp.

3.57%

Illumina, Inc.

3.54%

Halozyme Therapeutics, Inc.

3.51%

Bio-Techne Corp.

3.41%

Protagonist Therapeutics, Inc.

3.37%

Alnylam Pharmaceuticals, Inc.

3.31%

Frequently asked questions about TMED and PBE

How have the TMED and PBE ETFs performed in 2026?

As of October 22, 2026, TMED is up 16.23% year-to-date (YTD), while PBE has returned 21.44%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: TMED or PBE?

Year-to-date, the TMED ETF saw +$15M in flows, compared to +$113M for PBE.

Which ETF is more volatile: TMED or PBE?

Over the past year, TMED had a volatility of 18.68%, while PBE experienced 19.97%.

Which ETF is bigger: TMED or PBE?

As of October 22, 2026, TMED holds $34.50 M in assets under management (AUM), while PBE manages $429.04 M.

What sectors do the TMED and PBE ETFs invest in?

TMED leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.

What are the top holdings of the TMED ETF and PBE ETF?

TMED top holdings include Eli Lilly & Co., UnitedHealth Group, Inc. and Alnylam Pharmaceuticals, Inc.. PBE holds in its top three: CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc..

TMEDvsPBEETF Comparison

T. Rowe Price Health Care ETF

Invesco Dynamic Biotechnology & Genome ETF

TMED vs PBE performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the TMED and PBE ETFs performed in 2026?

As of October 22, 2026, TMED is up 16.23% year-to-date (YTD), while PBE has returned 21.44%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: TMED or PBE?

Year-to-date, the TMED ETF saw +$15M in flows, compared to +$113M for PBE.

Which ETF is more volatile: TMED or PBE?

Over the past year, TMED had a volatility of 18.68%, while PBE experienced 19.97%.

Which ETF is bigger: TMED or PBE?

As of October 22, 2026, TMED holds $34.50 M in assets under management (AUM), while PBE manages $429.04 M.

What sectors do the TMED and PBE ETFs invest in?

TMED leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.

What are the top holdings of the TMED ETF and PBE ETF?

TMED top holdings include Eli Lilly & Co., UnitedHealth Group, Inc. and Alnylam Pharmaceuticals, Inc.. PBE holds in its top three: CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc..

Which ETF is more diversified: TMED or PBE?

TMED holds 106 securities with 56.93% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.67%.

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