TDNAvsPTHETF Comparison
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T. Rowe Price Biotech ETF (TDNA) belongs to the Uncategorized Equities segment. Invesco DWA Healthcare Momentum ETF (PTH) is part of the US Health Care segment. TDNA's top 1 sector exposures are Healthcare. In contrast, PTH's top sector exposures are Healthcare and Consumer Non-Cyclicals. TDNA is less expensive with a Total Expense Ratio (TER) of 0.55%, versus 0.72% for PTH. Run a side-by-side ETF comparison of TDNA and PTH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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TDNA vs PTH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/29/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | TDNA PTH | +0.68%-1.69% | n/a+0.82% | n/a+20.14% | n/a+27.98% | n/a+107.64% | n/a+11.90% |
| Flows | TDNA PTH | +$568K-$67M | -+$56M | -+$149M | -+$158M | -+$102M | --$105M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | TDNA PTH | n/a+28.86% | n/a+27.09% | n/a+26.08% | n/a+25.94% |
| Max drawdown | TDNA PTH | n/a-12.72% | n/a-12.72% | n/a-27.71% | n/a-47.24% |
| Max drawdown duration | TDNA PTH | n/a72d | n/a72d | n/a353d | n/a1688d |
Trading data
TDNA | PTH | |
Last sale 10/30/2026 at 1:30 PM | $24.89 | $59.78 |
| Previous close 10/29/2026 | $25.17 | $61.26 |
| Consolidated volume 10/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of October 30, 2026
1-year trailing difference
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TDNA
is actively managed and doesn’t replicate an indexTDNA | PTH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/30/2026 at 1:30 PM
Live
Closed
TDNA | PTH | |
|---|---|---|
| Last price | $24.89 | $59.78 |
| 1D performance | -1.11% | -2.42% |
| AuM | $10.69 M | $295.06 M |
| E/R | 0.55% | 0.72% |
Characteristics
TDNA | PTH | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | T. Rowe Price | Invesco |
| Benchmark | - | Dorsey Wright Healthcare Technical Leaders Index |
| N° of holdings | 86 | 54 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | September 16, 2026 | October 12, 2006 |
| ESG | No | No |
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Exposure
Countries
TDNA
USA
88.46%
Other
11.54%
PTH
USA
90.51%
Other
9.49%
Sectors
TDNA
Healthcare
98.5%
Other
1.5%
PTH
Healthcare
99.23%
Other
0.77%
Diversification
TDNA
Total weight of top 15 holdings out of 15
37.16%
PTH
Total weight of top 15 holdings out of 15
51.15%
Top 15 holdings
Data as of September 30, 2026
TDNA
argenx SE
5.41%
Kymera Therapeutics, Inc.
4.04%
Kodiak Sciences, Inc.
2.68%
Insmed, Inc.
2.59%
Natera, Inc.
2.41%
Revolution Medicines, Inc.
2.37%
Vertex Pharmaceuticals, Inc.
2.25%
United Therapeutics Corp.
2.20%
Alnylam Pharmaceuticals, Inc.
1.98%
Dianthus Therapeutics, Inc.
1.91%
Praxis Precision Medicines, Inc.
1.91%
Moderna, Inc.
1.90%
Vaxcyte, Inc.
1.86%
Cytokinetics, Inc.
1.83%
Rhythm Pharmaceuticals, Inc.
1.81%
PTH
Moderna, Inc.
6.40%
Guardant Health, Inc.
5.11%
Roivant Sciences Ltd.
5.06%
Revolution Medicines, Inc.
4.98%
10X Genomics, Inc.
3.99%
BrightSpring Health Services, Inc.
3.58%
Axsome Therapeutics, Inc.
3.44%
Twist Bioscience Corp.
2.92%
Illumina, Inc.
2.59%
Liquidia Corp.
2.47%
Oruka Therapeutics, Inc.
2.23%
Travere Therapeutics, Inc.
2.23%
Erasca, Inc.
2.15%
Replimune Group, Inc.
2.03%
Axogen, Inc.
1.98%
Frequently asked questions about TDNA and PTH
Which ETF is bigger: TDNA or PTH?
As of October 29, 2026, TDNA holds $10.69 M in assets under management (AUM), while PTH manages $295.06 M.
What sectors do the TDNA and PTH ETFs invest in?
TDNA leans toward sectors like Healthcare. Meanwhile, PTH focuses on Healthcare.
What are the top holdings of the TDNA ETF and PTH ETF?
TDNA top holdings include argenx SE, Kymera Therapeutics, Inc. and Kodiak Sciences, Inc.. PTH holds in its top three: Moderna, Inc., Guardant Health, Inc. and Roivant Sciences Ltd..
Which ETF is more diversified: TDNA or PTH?
TDNA holds 86 securities with 37.16% of its assets in the top 15. PTH has 54 securities and a top 15 weight of 51.15%.
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Latest news about TDNA & PTH
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