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PBPHvsXLVIETF Comparison

ETF 1

PBPH

Portfolio Building Block World Pharma and Biotech Index ETF

This fund is part of

DM Large & Mid Cap

-0.7%

Full PBPH fund page

VS

ETF 2

XLVI

State Street Health Care Select Sector SPDR Premium Income Fund

This fund is part of

Options Strategies

-0.3%

Full XLVI fund page

Portfolio Building Block World Pharma and Biotech Index ETF (PBPH) belongs to the DM Large & Mid Cap segment. State Street Health Care Select Sector SPDR Premium Income Fund (XLVI) is part of the Options Strategies segment. PBPH's top 1 sector exposures are Healthcare. In contrast, XLVI's top sector exposures are Healthcare and Consumer Non-Cyclicals. PBPH is less expensive with a Total Expense Ratio (TER) of 0.13%, versus 0.35% for XLVI. PBPH is up 11.66% year-to-date (YTD) with +$968M in YTD flows. XLVI performs worse with 7.01% YTD performance, and +$15M in YTD flows. Run a side-by-side ETF comparison of PBPH and XLVI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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PBPH vs XLVI performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 09/14/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	PBPH XLVI	+1.74%-2.58%	+9.54%+4.76%	+11.66%+7.01%	n/a+18.05%	n/an/a	n/an/a
Flows	PBPH XLVI	+$35M+$5M	+$139M+$11M	+$968M+$15M	-+$25M	--	--

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	PBPH XLVI	+20.72%+12.26%	n/a+11.17%	n/an/a	n/an/a
Max drawdown	PBPH XLVI	-6.59%-4.94%	n/a-8.21%	n/an/a	n/an/a
Max drawdown duration	PBPH XLVI	20d20d	n/a115d	n/an/a	n/an/a

Trading data

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	PBPH	XLVI
Last sale 9/15/2026 at 3:17 PM	$28.09	$26.01
Previous close 09/14/2026	$28.21	$26.10
Consolidated volume 09/14/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of August 31, 2026

1-year trailing difference

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XLVI

is actively managed and doesn’t replicate an index

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	PBPH	XLVI
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/15/2026 at 3:17 PM

Live

Closed

	PBPH	XLVI
Last price	$28.09	$26.01
1D performance	-0.44%	-0.34%
AuM	$1.02 B	$26.57 M
E/R	0.13%	0.35%

Characteristics

	PBPH	XLVI
Management strategy	Passive	Active
Provider	Tidal	State Street Investment Management
Benchmark	BITA Global Pharma and Biotech Select Index	-
N° of holdings	52	59
Asset class	-	-
Trailing 12m distribution yield	Join	Join
Inception date	November 24, 2025	July 30, 2025
ESG	No	No

More PBPH data on Trackinsight

More XLVI data on Trackinsight

Exposure

Countries

PBPH

USA

65.24%

Switzerland

10.52%

United Kingdom

7.15%

Other

17.09%

XLVI

USA

97.34%

Other

2.66%

Sectors

PBPH

Healthcare

99.46%

Other

0.54%

XLVI

Healthcare

97.32%

Other

2.68%

Diversification

PBPH

Total weight of top 15 holdings out of 15

75.4%

XLVI

Total weight of top 15 holdings out of 15

71.63%

Top 15 holdings

Data as of July 31, 2026

PBPH

Eli Lilly & Co.

15.14%

Johnson & Johnson

9.55%

AbbVie, Inc.

7.06%

Merck & Co., Inc.

4.97%

Roche Holding AG

4.70%

Amgen, Inc.

4.62%

Novartis AG

4.45%

AstraZeneca PLC

3.88%

Gilead Sciences, Inc.

3.77%

Novo Nordisk A/S

3.75%

Pfizer Inc.

3.28%

Bristol Myers Squibb Co.

3.06%

Vertex Pharmaceuticals, Inc.

2.82%

GSK Plc

2.24%

Sanofi

2.10%

XLVI

Eli Lilly & Co.

15.45%

Johnson & Johnson

10.49%

AbbVie, Inc.

7.54%

UnitedHealth Group, Inc.

6.40%

Merck & Co., Inc.

5.47%

Thermo Fisher Scientific, Inc.

3.63%

Amgen, Inc.

3.53%

Abbott Laboratories

3.13%

Gilead Sciences, Inc.

2.75%

Pfizer Inc.

2.42%

Bristol Myers Squibb Co.

2.27%

CVS Health Corp.

2.27%

Intuitive Surgical, Inc.

2.13%

Danaher Corp.

2.09%

Vertex Pharmaceuticals, Inc.

2.06%

Frequently asked questions about PBPH and XLVI

How have the PBPH and XLVI ETFs performed in 2026?

As of September 14, 2026, PBPH is up 11.66% year-to-date (YTD), while XLVI has returned 7.01%. That puts PBPH better performer ahead so far this year.

Which ETF is attracting more investor money: PBPH or XLVI?

Year-to-date, the PBPH ETF saw +$968M in flows, compared to +$15M for XLVI.

Which ETF is bigger: PBPH or XLVI?

As of September 14, 2026, PBPH holds $1.02 B in assets under management (AUM), while XLVI manages $26.57 M.

What sectors do the PBPH and XLVI ETFs invest in?

PBPH leans toward sectors like Healthcare. Meanwhile, XLVI focuses on Healthcare.

What are the top holdings of the PBPH ETF and XLVI ETF?

PBPH top holdings include Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc.. XLVI holds in its top three: Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc..

PBPHvsXLVIETF Comparison

Portfolio Building Block World Pharma and Biotech Index ETF

State Street Health Care Select Sector SPDR Premium Income Fund

PBPH vs XLVI performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the PBPH and XLVI ETFs performed in 2026?

As of September 14, 2026, PBPH is up 11.66% year-to-date (YTD), while XLVI has returned 7.01%. That puts PBPH better performer ahead so far this year.

Which ETF is attracting more investor money: PBPH or XLVI?

Year-to-date, the PBPH ETF saw +$968M in flows, compared to +$15M for XLVI.

Which ETF is bigger: PBPH or XLVI?

As of September 14, 2026, PBPH holds $1.02 B in assets under management (AUM), while XLVI manages $26.57 M.

What sectors do the PBPH and XLVI ETFs invest in?

PBPH leans toward sectors like Healthcare. Meanwhile, XLVI focuses on Healthcare.

What are the top holdings of the PBPH ETF and XLVI ETF?

PBPH top holdings include Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc.. XLVI holds in its top three: Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc..

Which ETF is more diversified: PBPH or XLVI?

PBPH holds 53 securities with 75.4% of its assets in the top 15. XLVI has 59 securities and a top 15 weight of 71.63%.

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