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PBEvsXHSETF Comparison

ETF 1

PBE

Invesco Dynamic Biotechnology & Genome ETF

This fund is part of

BioTech & Genomics

+4.79%

Full PBE fund page

VS

ETF 2

XHS

State Street SPDR S&P Health Care Services ETF

This fund is part of

US Health Care

+0.44%

Full XHS fund page

Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. State Street SPDR S&P Health Care Services ETF (XHS) is part of the US Health Care segment. PBE's top 1 sector exposures are Healthcare. In contrast, XHS's top sector exposures are Healthcare, Consumer Non-Cyclicals and Business Services. PBE is more expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.35% for XHS. PBE is up 24.01% year-to-date (YTD) with +$113M in YTD flows. XHS performs better with 32.03% YTD performance, and +$105M in YTD flows. Run a side-by-side ETF comparison of PBE and XHS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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PBE vs XHS performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 10/27/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	PBE XHS	+3.48%+5.07%	+12.22%+5.73%	+24.01%+32.03%	+38.47%+33.85%	+95.94%+81.78%	+38.86%+38.75%
Flows	PBE XHS	-$947K-$13M	+$111M+$4M	+$113M+$105M	+$115M+$108M	+$62M+$79M	+$65M+$38M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	PBE XHS	+21.55%+17.13%	+20.01%+17.56%	+20.60%+18.29%	+22.69%+21.37%
Max drawdown	PBE XHS	-5.97%-5.21%	-11.70%-11.97%	-22.21%-14.46%	-32.63%-29.93%
Max drawdown duration	PBE XHS	46d30d	166d121d	324d250d	1468d1477d

Trading data

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	PBE	XHS
Last sale 10/28/2026 at 1:30 PM	$101.87	$142.73
Previous close 10/27/2026	$100.74	$140.98
Consolidated volume 10/27/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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	PBE	XHS
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/28/2026 at 1:30 PM

Live

Closed

	PBE	XHS
Last price	$101.87	$142.73
1D performance	+1.12%	+1.24%
AuM	$438.13 M	$222.80 M
E/R	0.59%	0.35%

Characteristics

	PBE	XHS
Management strategy	Passive	Passive
Provider	Invesco	State Street Investment Management
Benchmark	Dynamic Biotech & Genome Intellidex Index	S&P Health Care Services Select Industry Index
N° of holdings	30	59
Asset class	Equities	Equities
Trailing 12m distribution yield	Join	Join
Inception date	June 23, 2005	September 28, 2011
ESG	No	No

More PBE data on Trackinsight

More XHS data on Trackinsight

Exposure

Countries

PBE

USA

97.22%

Other

2.78%

XHS

USA

99.94%

Other

0.06%

Sectors

PBE

Healthcare

100%

Other

0%

XHS

Healthcare

95.16%

Other

4.84%

Diversification

PBE

Total weight of top 15 holdings out of 15

63.67%

XHS

Total weight of top 15 holdings out of 15

33.1%

Top 15 holdings

Data as of August 31, 2026

PBE

CareDx, Inc.

5.49%

Amgen, Inc.

5.38%

Regeneron Pharmaceuticals, Inc.

5.26%

Vertex Pharmaceuticals, Inc.

5.21%

Royalty Pharma Plc

4.76%

Biogen, Inc.

4.75%

Gilead Sciences, Inc.

4.61%

United Therapeutics Corp.

3.77%

Omeros Corp.

3.73%

Repligen Corp.

3.57%

Illumina, Inc.

3.54%

Halozyme Therapeutics, Inc.

3.51%

Bio-Techne Corp.

3.41%

Protagonist Therapeutics, Inc.

3.37%

Alnylam Pharmaceuticals, Inc.

3.31%

XHS

Tenet Healthcare Corp.

2.65%

NeoGenomics, Inc.

2.60%

Lifestance Health Group, Inc.

2.58%

GeneDx Holdings Corp.

2.56%

Hinge Health, Inc.

2.45%

RadNet, Inc.

2.14%

Concentra Group Holdings Parent, Inc.

2.08%

Aveanna Healthcare Holdings, Inc.

2.07%

Labcorp Holdings, Inc.

2.03%

U.S. Physical Therapy, Inc.

2.03%

PACS Group, Inc.

2.02%

Addus HomeCare Corp.

2.02%

Guardant Health, Inc.

1.99%

Chemed Corp.

1.96%

Quest Diagnostics, Inc.

1.93%

Frequently asked questions about PBE and XHS

How have the PBE and XHS ETFs performed in 2026?

As of October 27, 2026, PBE is up 24.01% year-to-date (YTD), while XHS has returned 32.03%. That puts XHS better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or XHS?

Year-to-date, the PBE ETF saw +$113M in flows, compared to +$105M for XHS.

Which ETF is more volatile: PBE or XHS?

Over the past year, PBE had a volatility of 20.01%, while XHS experienced 17.56%.

Which ETF is bigger: PBE or XHS?

As of October 27, 2026, PBE holds $438.13 M in assets under management (AUM), while XHS manages $222.80 M.

What sectors do the PBE and XHS ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, XHS focuses on Healthcare.

What are the top holdings of the PBE ETF and XHS ETF?

PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. XHS holds in its top three: Tenet Healthcare Corp., NeoGenomics, Inc. and Lifestance Health Group, Inc..

PBEvsXHSETF Comparison

Invesco Dynamic Biotechnology & Genome ETF

State Street SPDR S&P Health Care Services ETF

PBE vs XHS performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the PBE and XHS ETFs performed in 2026?

As of October 27, 2026, PBE is up 24.01% year-to-date (YTD), while XHS has returned 32.03%. That puts XHS better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or XHS?

Year-to-date, the PBE ETF saw +$113M in flows, compared to +$105M for XHS.

Which ETF is more volatile: PBE or XHS?

Over the past year, PBE had a volatility of 20.01%, while XHS experienced 17.56%.

Which ETF is bigger: PBE or XHS?

As of October 27, 2026, PBE holds $438.13 M in assets under management (AUM), while XHS manages $222.80 M.

What sectors do the PBE and XHS ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, XHS focuses on Healthcare.

What are the top holdings of the PBE ETF and XHS ETF?

PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. XHS holds in its top three: Tenet Healthcare Corp., NeoGenomics, Inc. and Lifestance Health Group, Inc..

Which ETF is more diversified: PBE or XHS?

PBE holds 30 securities with 63.67% of its assets in the top 15. XHS has 59 securities and a top 15 weight of 33.1%.

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