PBEvsXHEETF Comparison
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Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. State Street SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. PBE is more expensive with a Total Expense Ratio (TER) of 0.58%, versus 0.35% for XHE. PBE is up 2.54% year-to-date (YTD) with -$3M in YTD flows. XHE performs worse with -6.98% YTD performance, and -$535K in YTD flows. Run a side-by-side ETF comparison of PBE and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PBE vs XHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/12/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PBE XHE | +1.33%+4.32% | +10.39%+2.70% | +2.54%-6.98% | +31.31%+0.63% | +34.96%-13.93% | +10.44%-34.60% |
| Flows | PBE XHE | +$2M+$14M | -$3M+$4M | -$3M-$535K | -$26M-$33M | -$56M-$319M | -$45M-$381M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PBE XHE | +19.82%+25.26% | +19.09%+21.83% | +20.14%+21.71% | +22.41%+24.47% |
| Max drawdown | PBE XHE | -4.08%-8.81% | -11.70%-18.20% | -22.21%-32.46% | -34.74%-49.90% |
| Max drawdown duration | PBE XHE | 16d54d | 156d155d | 324d1061d | 1540d1744d |
Trading data
PBE | XHE | |
Last sale 6/12/2026 at 1:30 PM | $84.10 | $81.88 |
| Previous close 06/11/2026 | $84.82 | $82.05 |
| Consolidated volume 06/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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PBE | XHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/12/2026 at 1:30 PM
Live
Closed
PBE | XHE | |
|---|---|---|
| Last price | $84.10 | $81.88 |
| 1D performance | -0.85% | -0.21% |
| AuM | $259.85 M | $143.46 M |
| E/R | 0.58% | 0.35% |
Characteristics
PBE | XHE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | State Street Investment Management |
| Benchmark | Dynamic Biotech & Genome Intellidex Index | S&P Health Care Equipment Select Industry Index |
| N° of holdings | 30 | 60 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 23, 2005 | January 26, 2011 |
| ESG | No | No |
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Exposure
Countries
PBE
USA
92.2%
Other
7.8%
XHE
USA
92.03%
Other
7.97%
Sectors
PBE
Health Care
97.78%
Other
2.22%
XHE
Health Care
89.92%
Other
10.08%
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Diversification
PBE
Total weight of top 15 holdings out of 15
62.95%
XHE
Total weight of top 15 holdings out of 15
29.69%
Top 15 holdings
Data as of April 30, 2026
PBE
UTD THERAPEUT
6.20%
ILLUMINA
5.42%
REGENERON PHARMACEUTICALS
4.99%
INCYTE
4.91%
ALNYLAM PHARMACEUTICALS
4.80%
BIOGEN INC
4.80%
AMGEN-T
4.60%
GILEAD SCIENCES
4.48%
CATALYST PHARMACEUTICALS INC
3.42%
BIOCRYST PHARMACEUTICALS
3.30%
TG THERAPEUTICS
3.28%
ARROWHEAD PHARMACEUTICALS INC
3.27%
CAREDX INC/D
3.21%
PROTAGONIST THERAPEUTICS INC
3.18%
ROYALTY PHARMA
3.09%
XHE
STAAR SURGICAL
2.55%
GLAUKOS
2.39%
AXOGEN
2.29%
BUTTERFLY NETWORK INC
2.14%
NOVOCURE LTD
2.07%
AVANOS MEDICAL INC
2.05%
TELEFLEX
1.89%
OMNICELL
1.89%
IRHYTHM TECHNOLOGIES
1.84%
US58507V1070
1.79%
INTEGER HOLDINGS
1.78%
GLOBUS MEDICAL
1.77%
LANTHEUS HOLDINGS
1.76%
MASIMO
1.74%
LEMAITRE VASCULAR
1.73%
Frequently asked questions about PBE and XHE
How have the PBE and XHE ETFs performed in 2026?
As of June 12, 2026, PBE is up 2.54% year-to-date (YTD), while XHE has lost -6.98%. That puts PBE better performer ahead so far this year.
Which ETF is attracting more investor money: PBE or XHE?
Year-to-date, the PBE ETF saw -$3M in flows, compared to -$535K for XHE.
Which ETF is more volatile: PBE or XHE?
Over the past year, PBE had a volatility of 19.09%, while XHE experienced 21.83%.
Which ETF is bigger: PBE or XHE?
As of June 12, 2026, PBE holds $259.85 M in assets under management (AUM), while XHE manages $143.46 M.
What sectors do the PBE and XHE ETFs invest in?
PBE leans toward sectors like Health Care. Meanwhile, XHE focuses on Health Care.
What are the top holdings of the PBE ETF and XHE ETF?
PBE top holdings include UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS. XHE holds in its top three: STAAR SURGICAL, GLAUKOS and AXOGEN.
Which ETF is more diversified: PBE or XHE?
PBE holds 30 securities with 62.95% of its assets in the top 15. XHE has 66 securities and a top 15 weight of 29.69%.
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