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PBEvsXHEETF Comparison

ETF 1

PBE

Invesco Dynamic Biotechnology & Genome ETF

This fund is part of

BioTech & Genomics

-1.96%

Full PBE fund page

VS

ETF 2

XHE

State Street SPDR S&P Health Care Equipment ETF

This fund is part of

US Health Care

-0.76%

Full XHE fund page

Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. State Street SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. PBE's top 1 sector exposures are Healthcare. In contrast, XHE's top sector exposures are Healthcare and Finance. PBE is more expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.35% for XHE. PBE is up 14.59% year-to-date (YTD) with +$114M in YTD flows. XHE performs worse with 1.67% YTD performance, and +$13M in YTD flows. Run a side-by-side ETF comparison of PBE and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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PBE vs XHE performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 09/10/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	PBE XHE	-0.70%-4.95%	+12.83%+9.88%	+14.59%+1.67%	+35.63%+11.16%	+57.51%+7.03%	+23.66%-31.12%
Flows	PBE XHE	+$44M+$5M	+$117M+$14M	+$114M+$13M	+$113M+$2M	+$62M-$264M	+$64M-$380M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	PBE XHE	+19.58%+24.14%	+19.33%+22.78%	+20.48%+22.23%	+22.57%+24.84%
Max drawdown	PBE XHE	-5.73%-7.53%	-11.70%-18.20%	-22.21%-24.35%	-33.32%-49.37%
Max drawdown duration	PBE XHE	7d22d	166d207d	324d565d	1509d1772d

Trading data

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	PBE	XHE
Last sale 9/10/2026 at 1:30 PM	$93.03	$89.53
Previous close 09/10/2026	$94.60	$91.41
Consolidated volume 09/10/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of August 31, 2026

1-year trailing difference

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	PBE	XHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/10/2026 at 1:30 PM

Live

Closed

	PBE	XHE
Last price	$93.03	$89.53
1D performance	-1.66%	-2.06%
AuM	$405.87 M	$170.24 M
E/R	0.59%	0.35%

Characteristics

	PBE	XHE
Management strategy	Passive	Passive
Provider	Invesco	State Street Investment Management
Benchmark	Dynamic Biotech & Genome Intellidex Index	S&P Health Care Equipment Select Industry Index
N° of holdings	30	66
Asset class	Equities	Equities
Trailing 12m distribution yield	Join	Join
Inception date	June 23, 2005	January 26, 2011
ESG	No	No

More PBE data on Trackinsight

More XHE data on Trackinsight

Exposure

Countries

PBE

USA

97.13%

Other

2.87%

XHE

USA

93.56%

Other

6.44%

Sectors

PBE

Healthcare

100%

Other

0%

XHE

Healthcare

98.72%

Other

1.28%

Diversification

PBE

Total weight of top 15 holdings out of 15

61.32%

XHE

Total weight of top 15 holdings out of 15

30.19%

Top 15 holdings

Data as of July 31, 2026

PBE

Amgen, Inc.

5.16%

Vertex Pharmaceuticals, Inc.

4.96%

Royalty Pharma Plc

4.91%

Regeneron Pharmaceuticals, Inc.

4.90%

Biogen, Inc.

4.85%

Gilead Sciences, Inc.

4.44%

Alnylam Pharmaceuticals, Inc.

4.34%

United Therapeutics Corp.

4.06%

CareDx, Inc.

4.01%

Bio-Techne Corp.

3.66%

Illumina, Inc.

3.27%

Vericel Corp.

3.25%

Protagonist Therapeutics, Inc.

3.24%

Incyte Corp.

3.19%

Veracyte, Inc.

3.07%

XHE

AtriCure, Inc.

2.14%

Glaukos Corp.

2.13%

Dentsply Sirona, Inc.

2.08%

Enovis Corp.

2.07%

Integer Holdings Corp.

2.07%

Butterfly Network, Inc.

2.06%

Neogen Corp.

2.05%

Artivion, Inc.

2.05%

Baxter International, Inc.

2.01%

CONMED Corp.

1.99%

Merit Medical Systems, Inc.

1.98%

QuidelOrtho Corp.

1.94%

ICU Medical, Inc.

1.88%

Tandem Diabetes Care, Inc.

1.88%

Inspire Medical Systems, Inc.

1.85%

Frequently asked questions about PBE and XHE

How have the PBE and XHE ETFs performed in 2026?

As of September 10, 2026, PBE is up 14.59% year-to-date (YTD), while XHE has returned 1.67%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or XHE?

Year-to-date, the PBE ETF saw +$114M in flows, compared to +$13M for XHE.

Which ETF is more volatile: PBE or XHE?

Over the past year, PBE had a volatility of 19.33%, while XHE experienced 22.78%.

Which ETF is bigger: PBE or XHE?

As of September 10, 2026, PBE holds $405.87 M in assets under management (AUM), while XHE manages $170.24 M.

What sectors do the PBE and XHE ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, XHE focuses on Healthcare.

What are the top holdings of the PBE ETF and XHE ETF?

PBE top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Royalty Pharma Plc. XHE holds in its top three: AtriCure, Inc., Glaukos Corp. and Dentsply Sirona, Inc..

PBEvsXHEETF Comparison

Invesco Dynamic Biotechnology & Genome ETF

State Street SPDR S&P Health Care Equipment ETF

PBE vs XHE performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the PBE and XHE ETFs performed in 2026?

As of September 10, 2026, PBE is up 14.59% year-to-date (YTD), while XHE has returned 1.67%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or XHE?

Year-to-date, the PBE ETF saw +$114M in flows, compared to +$13M for XHE.

Which ETF is more volatile: PBE or XHE?

Over the past year, PBE had a volatility of 19.33%, while XHE experienced 22.78%.

Which ETF is bigger: PBE or XHE?

As of September 10, 2026, PBE holds $405.87 M in assets under management (AUM), while XHE manages $170.24 M.

What sectors do the PBE and XHE ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, XHE focuses on Healthcare.

What are the top holdings of the PBE ETF and XHE ETF?

PBE top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Royalty Pharma Plc. XHE holds in its top three: AtriCure, Inc., Glaukos Corp. and Dentsply Sirona, Inc..

Which ETF is more diversified: PBE or XHE?

PBE holds 30 securities with 61.32% of its assets in the top 15. XHE has 66 securities and a top 15 weight of 30.19%.

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