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PBEvsTMEDETF Comparison

ETF 1

PBE

Invesco Dynamic Biotechnology & Genome ETF

This fund is part of

BioTech & Genomics

+0.97%

Full PBE fund page

VS

ETF 2

TMED

T. Rowe Price Health Care ETF

This fund is part of

US Health Care

+0.14%

Full TMED fund page

Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. T. Rowe Price Health Care ETF (TMED) is part of the US Health Care segment. PBE's top 1 sector exposures are Healthcare. In contrast, TMED's top sector exposures are Healthcare, Consumer Non-Cyclicals and Non-Corporate. PBE is more expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.44% for TMED. PBE is up 22.24% year-to-date (YTD) with +$113M in YTD flows. TMED performs worse with 14.72% YTD performance, and +$15M in YTD flows. Run a side-by-side ETF comparison of PBE and TMED below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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PBE vs TMED performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 10/26/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	PBE TMED	+2.00%+0.45%	+10.62%-0.56%	+22.24%+14.72%	+36.49%+19.86%	+87.45%n/a	+34.51%n/a
Flows	PBE TMED	-$947K+$2M	+$111M+$10M	+$113M+$15M	+$115M+$16M	+$62M-	+$65M-

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	PBE TMED	+21.57%+19.35%	+20.01%+18.72%	+20.66%n/a	+22.69%n/a
Max drawdown	PBE TMED	-5.97%-10.10%	-11.70%-11.09%	-22.21%n/a	-32.63%n/a
Max drawdown duration	PBE TMED	46d65d	166d125d	324dn/a	1468dn/a

Trading data

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	PBE	TMED
Last sale 10/27/2026 at 1:30 PM	$100.74	$34.45
Previous close 10/26/2026	$99.21	$34.19
Consolidated volume 10/26/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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TMED

is actively managed and doesn’t replicate an index

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	PBE	TMED
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/27/2026 at 1:30 PM

Live

Closed

	PBE	TMED
Last price	$100.74	$34.45
1D performance	+1.55%	+0.75%
AuM	$431.86 M	$34.05 M
E/R	0.59%	0.44%

Characteristics

	PBE	TMED
Management strategy	Passive	Active
Provider	Invesco	T. Rowe Price
Benchmark	Dynamic Biotech & Genome Intellidex Index	-
N° of holdings	30	106
Asset class	Equities	-
Trailing 12m distribution yield	Join	Join
Inception date	June 23, 2005	June 11, 2025
ESG	No	No

More PBE data on Trackinsight

More TMED data on Trackinsight

Exposure

Countries

PBE

USA

97.22%

Other

2.78%

TMED

USA

92.86%

Other

7.14%

Sectors

PBE

Healthcare

100%

Other

0%

TMED

Healthcare

98.26%

Other

1.74%

Diversification

PBE

Total weight of top 15 holdings out of 15

63.67%

TMED

Total weight of top 15 holdings out of 15

56.93%

Top 15 holdings

Data as of August 31, 2026

PBE

CareDx, Inc.

5.49%

Amgen, Inc.

5.38%

Regeneron Pharmaceuticals, Inc.

5.26%

Vertex Pharmaceuticals, Inc.

5.21%

Royalty Pharma Plc

4.76%

Biogen, Inc.

4.75%

Gilead Sciences, Inc.

4.61%

United Therapeutics Corp.

3.77%

Omeros Corp.

3.73%

Repligen Corp.

3.57%

Illumina, Inc.

3.54%

Halozyme Therapeutics, Inc.

3.51%

Bio-Techne Corp.

3.41%

Protagonist Therapeutics, Inc.

3.37%

Alnylam Pharmaceuticals, Inc.

3.31%

TMED

Eli Lilly & Co.

13.87%

UnitedHealth Group, Inc.

5.32%

Alnylam Pharmaceuticals, Inc.

5.20%

Thermo Fisher Scientific, Inc.

3.74%

Cencora, Inc.

3.65%

Insulet Corp.

3.23%

Gilead Sciences, Inc.

2.99%

Agilent Technologies, Inc.

2.85%

Elanco Animal Health, Inc.

2.63%

Dyne Therapeutics, Inc.

2.47%

Boston Scientific Corp.

2.25%

Stryker Corp.

2.21%

Danaher Corp.

2.20%

Waters Corp.

2.17%

West Pharmaceutical Services, Inc.

2.16%

Frequently asked questions about PBE and TMED

How have the PBE and TMED ETFs performed in 2026?

As of October 26, 2026, PBE is up 22.24% year-to-date (YTD), while TMED has returned 14.72%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or TMED?

Year-to-date, the PBE ETF saw +$113M in flows, compared to +$15M for TMED.

Which ETF is more volatile: PBE or TMED?

Over the past year, PBE had a volatility of 20.01%, while TMED experienced 18.72%.

Which ETF is bigger: PBE or TMED?

As of October 26, 2026, PBE holds $431.86 M in assets under management (AUM), while TMED manages $34.05 M.

What sectors do the PBE and TMED ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, TMED focuses on Healthcare.

What are the top holdings of the PBE ETF and TMED ETF?

PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. TMED holds in its top three: Eli Lilly & Co., UnitedHealth Group, Inc. and Alnylam Pharmaceuticals, Inc..

PBEvsTMEDETF Comparison

Invesco Dynamic Biotechnology & Genome ETF

T. Rowe Price Health Care ETF

PBE vs TMED performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the PBE and TMED ETFs performed in 2026?

As of October 26, 2026, PBE is up 22.24% year-to-date (YTD), while TMED has returned 14.72%. That puts PBE better performer ahead so far this year.

Which ETF is attracting more investor money: PBE or TMED?

Year-to-date, the PBE ETF saw +$113M in flows, compared to +$15M for TMED.

Which ETF is more volatile: PBE or TMED?

Over the past year, PBE had a volatility of 20.01%, while TMED experienced 18.72%.

Which ETF is bigger: PBE or TMED?

As of October 26, 2026, PBE holds $431.86 M in assets under management (AUM), while TMED manages $34.05 M.

What sectors do the PBE and TMED ETFs invest in?

PBE leans toward sectors like Healthcare. Meanwhile, TMED focuses on Healthcare.

What are the top holdings of the PBE ETF and TMED ETF?

PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. TMED holds in its top three: Eli Lilly & Co., UnitedHealth Group, Inc. and Alnylam Pharmaceuticals, Inc..

Which ETF is more diversified: PBE or TMED?

PBE holds 30 securities with 63.67% of its assets in the top 15. TMED has 106 securities and a top 15 weight of 56.93%.

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