PBEvsHELXETF Comparison
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Invesco Dynamic Biotechnology & Genome ETF (PBE) and Franklin Genomic Advancements ETF (HELX) belong to the same industry segment: BioTech & Genomics. Both ETFs have the same top 3 sector exposures: and Health Care. PBE is more expensive with a Total Expense Ratio (TER) of 0.58%, versus 0.5% for HELX. PBE is up 2.54% year-to-date (YTD) with -$3M in YTD flows. HELX performs worse with -2.29% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of PBE and HELX below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PBE vs HELX performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/12/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PBE HELX | +1.33%+4.54% | +10.39%+10.40% | +2.54%-2.29% | +31.31%+28.69% | +34.96%+15.30% | +10.44%-24.55% |
| Flows | PBE HELX | +$2M- | -$3M- | -$3M+$2M | -$26M+$8M | -$56M+$9M | -$45M+$14M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PBE HELX | +19.82%+26.36% | +19.09%+21.07% | +20.14%+20.62% | +22.41%+23.64% |
| Max drawdown | PBE HELX | -4.08%-6.54% | -11.70%-17.89% | -22.21%-29.16% | -34.74%-58.50% |
| Max drawdown duration | PBE HELX | 16d38d | 156d194d | 324d458d | 1540d1739d |
Trading data
PBE | HELX | |
Last sale 6/15/2026 at 1:30 PM | $84.78 | $35.82 |
| Previous close 06/12/2026 | $84.10 | $35.45 |
| Consolidated volume 06/12/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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HELX
is actively managed and doesn’t replicate an indexPBE | HELX | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/15/2026 at 1:30 PM
Live
Closed
PBE | HELX | |
|---|---|---|
| Last price | $84.78 | $35.82 |
| 1D performance | +0.81% | +1.03% |
| AuM | $259.85 M | $23.05 M |
| E/R | 0.58% | 0.5% |
Characteristics
PBE | HELX | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | Invesco | Franklin Templeton |
| Benchmark | Dynamic Biotech & Genome Intellidex Index | - |
| N° of holdings | 30 | 50 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 23, 2005 | February 25, 2020 |
| ESG | No | No |
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Exposure
Countries
PBE
USA
92.2%
Other
7.8%
HELX
USA
87.65%
Other
12.35%
Sectors
PBE
Health Care
97.78%
Other
2.22%
HELX
Health Care
89.42%
Other
10.58%
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Diversification
PBE
Total weight of top 15 holdings out of 15
62.95%
HELX
Total weight of top 15 holdings out of 15
58.48%
Top 15 holdings
Data as of April 30, 2026
PBE
UTD THERAPEUT
6.20%
ILLUMINA
5.42%
REGENERON PHARMACEUTICALS
4.99%
INCYTE
4.91%
ALNYLAM PHARMACEUTICALS
4.80%
BIOGEN INC
4.80%
AMGEN-T
4.60%
GILEAD SCIENCES
4.48%
CATALYST PHARMACEUTICALS INC
3.42%
BIOCRYST PHARMACEUTICALS
3.30%
TG THERAPEUTICS
3.28%
ARROWHEAD PHARMACEUTICALS INC
3.27%
CAREDX INC/D
3.21%
PROTAGONIST THERAPEUTICS INC
3.18%
ROYALTY PHARMA
3.09%
HELX
NATERA
6.86%
GUARDANT HEALTH INC
6.56%
KRYSTAL BIOTECH INC
5.67%
UTD THERAPEUT
4.48%
LIGAND PHARMACEUTICALS
4.31%
BRIDGEBIO PHARMA
4.28%
INSMED
3.80%
ASTRAZENECA
3.26%
ADAPTIVE BIOTECHNOLOGIES
3.23%
SAMSUNG BIOLOGICS CO LTD
3.14%
VERTEX PHARMACEUTICALS
2.87%
REGENERON PHARMACEUTICALS
2.60%
CORTEVA INC
2.58%
ALNYLAM PHARMACEUTICALS
2.44%
LILLY
2.39%
Frequently asked questions about PBE and HELX
How have the PBE and HELX ETFs performed in 2026?
As of June 12, 2026, PBE is up 2.54% year-to-date (YTD), while HELX has lost -2.29%. That puts PBE better performer ahead so far this year.
Which ETF is attracting more investor money: PBE or HELX?
Year-to-date, the PBE ETF saw -$3M in flows, compared to +$2M for HELX.
Which ETF is more volatile: PBE or HELX?
Over the past year, PBE had a volatility of 19.09%, while HELX experienced 21.07%.
Which ETF is bigger: PBE or HELX?
As of June 12, 2026, PBE holds $259.85 M in assets under management (AUM), while HELX manages $23.05 M.
What sectors do the PBE and HELX ETFs invest in?
PBE leans toward sectors like Health Care. Meanwhile, HELX focuses on Health Care.
What are the top holdings of the PBE ETF and HELX ETF?
PBE top holdings include UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS. HELX holds in its top three: NATERA, GUARDANT HEALTH INC and KRYSTAL BIOTECH INC.
Which ETF is more diversified: PBE or HELX?
PBE holds 30 securities with 62.95% of its assets in the top 15. HELX has 60 securities and a top 15 weight of 58.48%.
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