PBEvsFXHETF Comparison
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Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. First Trust Health Care AlphaDEX Fund ETF (FXH) is part of the US Health Care segment. Both ETFs have the same top 1 sector exposures: Healthcare. PBE is less expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.61% for FXH. PBE is up 24.01% year-to-date (YTD) with +$113M in YTD flows. FXH performs worse with 19.23% YTD performance, and +$33M in YTD flows. Run a side-by-side ETF comparison of PBE and FXH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PBE vs FXH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PBE FXH | +3.48%+2.43% | +12.22%+8.19% | +24.01%+19.23% | +38.47%+19.78% | +95.94%+52.55% | +38.86%+16.55% |
| Flows | PBE FXH | -$947K-$39M | +$111M+$39M | +$113M+$33M | +$115M+$39M | +$62M-$459M | +$65M-$464M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PBE FXH | +21.55%+15.19% | +20.01%+15.66% | +20.60%+15.64% | +22.69%+16.95% |
| Max drawdown | PBE FXH | -5.97%-4.82% | -11.70%-12.07% | -22.21%-17.66% | -32.63%-27.47% |
| Max drawdown duration | PBE FXH | 46d55d | 166d168d | 324d395d | 1468d1638d |
Trading data
PBE | FXH | |
Last sale 10/28/2026 at 1:30 PM | $101.87 | $136.04 |
| Previous close 10/27/2026 | $100.74 | $134.95 |
| Consolidated volume 10/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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PBE | FXH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/28/2026 at 1:30 PM
Live
Closed
PBE | FXH | |
|---|---|---|
| Last price | $101.87 | $136.04 |
| 1D performance | +1.12% | +0.81% |
| AuM | $438.13 M | $1.14 B |
| E/R | 0.59% | 0.61% |
Characteristics
PBE | FXH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | First Trust |
| Benchmark | Dynamic Biotech & Genome Intellidex Index | StrataQuant Health Care Index |
| N° of holdings | 30 | 72 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 23, 2005 | May 8, 2007 |
| ESG | No | No |
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Exposure
Countries
PBE
USA
97.22%
Other
2.78%
FXH
USA
93.13%
Other
6.87%
Sectors
PBE
Healthcare
100%
Other
0%
FXH
Healthcare
98.23%
Other
1.77%
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Diversification
PBE
Total weight of top 15 holdings out of 15
63.67%
FXH
Total weight of top 15 holdings out of 15
35.47%
Top 15 holdings
Data as of August 31, 2026
PBE
CareDx, Inc.
5.49%
Amgen, Inc.
5.38%
Regeneron Pharmaceuticals, Inc.
5.26%
Vertex Pharmaceuticals, Inc.
5.21%
Royalty Pharma Plc
4.76%
Biogen, Inc.
4.75%
Gilead Sciences, Inc.
4.61%
United Therapeutics Corp.
3.77%
Omeros Corp.
3.73%
Repligen Corp.
3.57%
Illumina, Inc.
3.54%
Halozyme Therapeutics, Inc.
3.51%
Bio-Techne Corp.
3.41%
Protagonist Therapeutics, Inc.
3.37%
Alnylam Pharmaceuticals, Inc.
3.31%
FXH
Regeneron Pharmaceuticals, Inc.
2.86%
Pfizer Inc.
2.56%
Natera, Inc.
2.55%
Solventum Corp.
2.55%
Zimmer Biomet Holdings, Inc.
2.49%
Universal Health Services, Inc.
2.48%
Boston Scientific Corp.
2.43%
Guardant Health, Inc.
2.37%
Tenet Healthcare Corp.
2.29%
Halozyme Therapeutics, Inc.
2.22%
The Cigna Group
2.22%
Centene Corp.
2.20%
Globus Medical, Inc.
2.20%
Corcept Therapeutics, Inc.
2.10%
Encompass Health Corp.
1.95%
Frequently asked questions about PBE and FXH
How have the PBE and FXH ETFs performed in 2026?
As of October 27, 2026, PBE is up 24.01% year-to-date (YTD), while FXH has returned 19.23%. That puts PBE better performer ahead so far this year.
Which ETF is attracting more investor money: PBE or FXH?
Year-to-date, the PBE ETF saw +$113M in flows, compared to +$33M for FXH.
Which ETF is more volatile: PBE or FXH?
Over the past year, PBE had a volatility of 20.01%, while FXH experienced 15.66%.
Which ETF is bigger: PBE or FXH?
As of October 27, 2026, PBE holds $438.13 M in assets under management (AUM), while FXH manages $1.14 B.
What sectors do the PBE and FXH ETFs invest in?
PBE leans toward sectors like Healthcare. Meanwhile, FXH focuses on Healthcare.
What are the top holdings of the PBE ETF and FXH ETF?
PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. FXH holds in its top three: Regeneron Pharmaceuticals, Inc., Pfizer Inc. and Natera, Inc..
Which ETF is more diversified: PBE or FXH?
PBE holds 30 securities with 63.67% of its assets in the top 15. FXH has 72 securities and a top 15 weight of 35.47%.
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