PBEvsFBTETF Comparison
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Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Health Care. PBE is more expensive with a Total Expense Ratio (TER) of 0.58%, versus 0.54% for FBT. PBE is down -2.66% year-to-date (YTD) with -$2M in YTD flows. FBT performs better with -0.93% YTD performance, and +$1.07B in YTD flows. Run a side-by-side ETF comparison of PBE and FBT below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PBE vs FBT performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PBE FBT | +4.27%+6.35% | -3.98%-6.86% | -2.66%-0.93% | +32.11%+29.41% | +28.24%+31.14% | +3.38%+24.73% |
| Flows | PBE FBT | +$2M-$20M | -$6M+$101M | -$2M+$1.07B | -$30M+$1.08B | -$58M+$617M | -$43M+$289M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PBE FBT | +19.57%+23.37% | +19.83%+21.80% | +20.15%+20.22% | +22.54%+21.89% |
| Max drawdown | PBE FBT | -9.36%-13.39% | -11.70%-14.27% | -22.21%-19.92% | -34.74%-29.98% |
| Max drawdown duration | PBE FBT | 75d87d | 107d91d | 324d237d | 1540d1243d |
Trading data
PBE | FBT | |
Last sale 4/27/2026 at 4:03 PM | $80.57 | $204.75 |
| Previous close 04/24/2026 | $79.82 | $204.04 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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PBE | FBT | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/27/2026 at 4:03 PM
Live
Closed
PBE | FBT | |
|---|---|---|
| Last price | $80.57 | $204.75 |
| 1D performance | +0.94% | +0.35% |
| AuM | $249.88 M | $2.31 B |
| E/R | 0.58% | 0.54% |
Characteristics
PBE | FBT | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | First Trust |
| Benchmark | Dynamic Biotech & Genome Intellidex Index | NYSE Arca Biotechnology Index |
| N° of holdings | 30 | 28 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 23, 2005 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
PBE
USA
92.18%
Other
7.82%
FBT
USA
95.76%
Other
4.24%
Sectors
PBE
Health Care
97.59%
Other
2.41%
FBT
Health Care
90.59%
Other
9.41%
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Diversification
PBE
Total weight of top 15 holdings out of 15
63.66%
FBT
Total weight of top 15 holdings out of 15
56.66%
Top 15 holdings
Data as of March 31, 2026
PBE
UTD THERAPEUT
6.05%
ILLUMINA
5.24%
REGENERON PHARMACEUTICALS
5.23%
ALNYLAM PHARMACEUTICALS
5.22%
BIOGEN INC
5.16%
AMGEN-T
4.99%
GILEAD SCIENCES
4.98%
INCYTE
4.89%
BIOCRYST PHARMACEUTICALS
3.66%
PROTAGONIST THERAPEUTICS INC
3.38%
TG THERAPEUTICS
3.11%
ROYALTY PHARMA
3.05%
NEUROCRINE BIOSCIENCES
2.93%
CATALYST PHARMACEUTICALS INC
2.89%
PTC THERAPEUTI/D
2.86%
FBT
MODERNA INC
5.14%
ALKERMES
4.16%
UTD THERAPEUT
4.15%
GILEAD SCIENCES
4.08%
CORCEPT THERAPEUTICS
3.94%
AXSOME THERA CMN STK
3.91%
AMGEN-T
3.81%
EXELIXIS
3.52%
KRYSTAL BIOTECH INC
3.49%
BIOGEN INC
3.45%
REGENERON PHARMACEUTICALS
3.44%
NEUROCRINE BIOSCIENCES
3.44%
BIOMARIN PHARMACEUTICAL
3.42%
VERTEX PHARMACEUTICALS
3.39%
US04016X1019
3.32%
Frequently asked questions about PBE and FBT
How have the PBE and FBT ETFs performed in 2026?
As of April 24, 2026, PBE is down -2.66% year-to-date (YTD), while FBT has lost -0.93%. That puts FBT better performer ahead so far this year.
Which ETF is attracting more investor money: PBE or FBT?
Year-to-date, the PBE ETF saw -$2M in flows, compared to +$1.07B for FBT.
Which ETF is more volatile: PBE or FBT?
Over the past year, PBE had a volatility of 19.83%, while FBT experienced 21.8%.
Which ETF is bigger: PBE or FBT?
As of April 24, 2026, PBE holds $249.88 M in assets under management (AUM), while FBT manages $2.31 B.
What sectors do the PBE and FBT ETFs invest in?
PBE leans toward sectors like Health Care. Meanwhile, FBT focuses on Health Care.
What are the top holdings of the PBE ETF and FBT ETF?
PBE top holdings include UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS. FBT holds in its top three: MODERNA INC, ALKERMES and UTD THERAPEUT.
Which ETF is more diversified: PBE or FBT?
PBE holds 30 securities with 63.66% of its assets in the top 15. FBT has 30 securities and a top 15 weight of 56.66%.
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Latest news about PBE & FBT
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