PBEvsFBTETF Comparison
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Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) is part of the US Health Care segment. Both ETFs have the same top 1 sector exposures: Healthcare. PBE is more expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.54% for FBT. PBE is up 24.01% year-to-date (YTD) with +$113M in YTD flows. FBT performs better with 32.86% YTD performance, and +$1.00B in YTD flows. Run a side-by-side ETF comparison of PBE and FBT below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PBE vs FBT performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PBE FBT | +3.48%+0.05% | +12.22%+10.82% | +24.01%+32.86% | +38.47%+43.61% | +95.94%+107.80% | +38.86%+69.29% |
| Flows | PBE FBT | -$947K+$40M | +$111M-$22M | +$113M+$1.00B | +$115M+$1.09B | +$62M+$723M | +$65M+$356M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PBE FBT | +21.55%+22.67% | +20.01%+22.17% | +20.60%+21.18% | +22.69%+22.27% |
| Max drawdown | PBE FBT | -5.97%-5.30% | -11.70%-14.27% | -22.21%-19.92% | -32.63%-27.40% |
| Max drawdown duration | PBE FBT | 46d61d | 166d126d | 324d237d | 1468d1017d |
Trading data
PBE | FBT | |
Last sale 10/28/2026 at 1:30 PM | $101.87 | $279.50 |
| Previous close 10/27/2026 | $100.74 | $273.73 |
| Consolidated volume 10/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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PBE | FBT | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/28/2026 at 1:30 PM
Live
Closed
PBE | FBT | |
|---|---|---|
| Last price | $101.87 | $279.50 |
| 1D performance | +1.12% | +2.11% |
| AuM | $438.13 M | $3.02 B |
| E/R | 0.59% | 0.54% |
Characteristics
PBE | FBT | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | First Trust |
| Benchmark | Dynamic Biotech & Genome Intellidex Index | NYSE Arca Biotechnology Index |
| N° of holdings | 30 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 23, 2005 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
PBE
USA
97.22%
Other
2.78%
FBT
USA
82.68%
Other
17.32%
Sectors
PBE
Healthcare
100%
Other
0%
FBT
Healthcare
99.86%
Other
0.14%
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Diversification
PBE
Total weight of top 15 holdings out of 15
63.67%
FBT
Total weight of top 15 holdings out of 15
55.27%
Top 15 holdings
Data as of August 31, 2026
PBE
CareDx, Inc.
5.49%
Amgen, Inc.
5.38%
Regeneron Pharmaceuticals, Inc.
5.26%
Vertex Pharmaceuticals, Inc.
5.21%
Royalty Pharma Plc
4.76%
Biogen, Inc.
4.75%
Gilead Sciences, Inc.
4.61%
United Therapeutics Corp.
3.77%
Omeros Corp.
3.73%
Repligen Corp.
3.57%
Illumina, Inc.
3.54%
Halozyme Therapeutics, Inc.
3.51%
Bio-Techne Corp.
3.41%
Protagonist Therapeutics, Inc.
3.37%
Alnylam Pharmaceuticals, Inc.
3.31%
FBT
Halozyme Therapeutics, Inc.
4.38%
Regeneron Pharmaceuticals, Inc.
3.84%
NeoGenomics, Inc.
3.83%
Corcept Therapeutics, Inc.
3.82%
Amgen, Inc.
3.74%
BeOne Medicines Ltd.
3.72%
Natera, Inc.
3.68%
Repligen Corp.
3.65%
argenx SE
3.63%
Gilead Sciences, Inc.
3.58%
Genmab A/S
3.56%
Vertex Pharmaceuticals, Inc.
3.50%
Sarepta Therapeutics, Inc.
3.49%
BioNTech SE
3.45%
BioMarin Pharmaceutical, Inc.
3.40%
Frequently asked questions about PBE and FBT
How have the PBE and FBT ETFs performed in 2026?
As of October 27, 2026, PBE is up 24.01% year-to-date (YTD), while FBT has returned 32.86%. That puts FBT better performer ahead so far this year.
Which ETF is attracting more investor money: PBE or FBT?
Year-to-date, the PBE ETF saw +$113M in flows, compared to +$1.00B for FBT.
Which ETF is more volatile: PBE or FBT?
Over the past year, PBE had a volatility of 20.01%, while FBT experienced 22.17%.
Which ETF is bigger: PBE or FBT?
As of October 27, 2026, PBE holds $438.13 M in assets under management (AUM), while FBT manages $3.02 B.
What sectors do the PBE and FBT ETFs invest in?
PBE leans toward sectors like Healthcare. Meanwhile, FBT focuses on Healthcare.
What are the top holdings of the PBE ETF and FBT ETF?
PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. FBT holds in its top three: Halozyme Therapeutics, Inc., Regeneron Pharmaceuticals, Inc. and NeoGenomics, Inc..
Which ETF is more diversified: PBE or FBT?
PBE holds 30 securities with 63.67% of its assets in the top 15. FBT has 30 securities and a top 15 weight of 55.27%.
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Latest news about PBE & FBT
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