PBEvsBBPETF Comparison
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Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. Virtus LifeSci Biotech Products ETF (BBP) is part of the Tomorrow's Treatments segment. Both ETFs have the same top 3 sector exposures: and Health Care. PBE is less expensive with a Total Expense Ratio (TER) of 0.58%, versus 0.79% for BBP. PBE is up 3.55% year-to-date (YTD) with -$3M in YTD flows. BBP performs better with 10.61% YTD performance, and +$43M in YTD flows. Run a side-by-side ETF comparison of PBE and BBP below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PBE vs BBP performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/15/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PBE BBP | +5.04%+2.57% | +9.99%+7.07% | +3.55%+10.61% | +33.11%+48.05% | +35.81%+60.62% | +12.88%+63.92% |
| Flows | PBE BBP | +$2M+$18M | -$3M+$39M | -$3M+$43M | -$25M+$55M | -$56M+$58M | -$45M+$51M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PBE BBP | +19.90%+28.98% | +19.09%+24.08% | +20.14%+24.02% | +22.41%+26.35% |
| Max drawdown | PBE BBP | -4.08%-7.49% | -11.70%-9.59% | -22.21%-25.54% | -34.74%-37.87% |
| Max drawdown duration | PBE BBP | 16d40d | 159d48d | 324d292d | 1540d760d |
Trading data
PBE | BBP | |
Last sale 6/15/2026 at 1:30 PM | $84.78 | $88.06 |
| Previous close 06/15/2026 | $84.10 | $87.17 |
| Consolidated volume 06/15/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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PBE | BBP | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/15/2026 at 1:30 PM
Live
Closed
PBE | BBP | |
|---|---|---|
| Last price | $84.78 | $88.06 |
| 1D performance | +0.81% | +1.02% |
| AuM | $262.42 M | $92.63 M |
| E/R | 0.58% | 0.79% |
Characteristics
PBE | BBP | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | VIRTUS Investment Partners |
| Benchmark | Dynamic Biotech & Genome Intellidex Index | LifeSci Biotechnology Products Index |
| N° of holdings | 30 | 55 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 23, 2005 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
PBE
USA
92.2%
Other
7.8%
BBP
USA
84.13%
Other
15.87%
Sectors
PBE
Health Care
97.78%
Other
2.22%
BBP
Health Care
85.97%
Other
14.03%
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Diversification
PBE
Total weight of top 15 holdings out of 15
62.95%
BBP
Total weight of top 15 holdings out of 15
45.32%
Top 15 holdings
Data as of April 30, 2026
PBE
UTD THERAPEUT
6.20%
ILLUMINA
5.42%
REGENERON PHARMACEUTICALS
4.99%
INCYTE
4.91%
ALNYLAM PHARMACEUTICALS
4.80%
BIOGEN INC
4.80%
AMGEN-T
4.60%
GILEAD SCIENCES
4.48%
CATALYST PHARMACEUTICALS INC
3.42%
BIOCRYST PHARMACEUTICALS
3.30%
TG THERAPEUTICS
3.28%
ARROWHEAD PHARMACEUTICALS INC
3.27%
CAREDX INC/D
3.21%
PROTAGONIST THERAPEUTICS INC
3.18%
ROYALTY PHARMA
3.09%
BBP
ARROWHEAD PHARMACEUTICALS INC
3.17%
GB00BRXB0C07
3.17%
BIOGEN INC
3.14%
HALOZYME THERAPEUTICS
3.13%
AURINIA PHARMACEUTICALS INC
3.12%
SYNDAX PHARMACEUTICALS INC
3.12%
BIOMARIN PHARMACEUTICAL
3.05%
INCYTE
3.03%
REGENERON PHARMACEUTICALS
3.03%
BRIDGEBIO PHARMA
3.00%
SAREPTA THERAPEUTICS INC DE
2.95%
ARDELYX
2.92%
VERTEX PHARMACEUTICALS
2.85%
US07725L1026
2.83%
THERAVANCE BIOPHARMA
2.80%
Frequently asked questions about PBE and BBP
How have the PBE and BBP ETFs performed in 2026?
As of June 15, 2026, PBE is up 3.55% year-to-date (YTD), while BBP has returned 10.61%. That puts BBP better performer ahead so far this year.
Which ETF is attracting more investor money: PBE or BBP?
Year-to-date, the PBE ETF saw -$3M in flows, compared to +$43M for BBP.
Which ETF is more volatile: PBE or BBP?
Over the past year, PBE had a volatility of 19.09%, while BBP experienced 24.08%.
Which ETF is bigger: PBE or BBP?
As of June 15, 2026, PBE holds $262.42 M in assets under management (AUM), while BBP manages $92.63 M.
What sectors do the PBE and BBP ETFs invest in?
PBE leans toward sectors like Health Care. Meanwhile, BBP focuses on Health Care.
What are the top holdings of the PBE ETF and BBP ETF?
PBE top holdings include UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS. BBP holds in its top three: ARROWHEAD PHARMACEUTICALS INC, GB00BRXB0C07 and BIOGEN INC.
Which ETF is more diversified: PBE or BBP?
PBE holds 30 securities with 62.95% of its assets in the top 15. BBP has 59 securities and a top 15 weight of 45.32%.
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