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LFSCvsXHEETF Comparison

ETF 1
LFSC

F/m Emerald Life Sciences Innovation ETF

This fund is part of
Life Sciences
-3.41%
Full LFSC fund page
VS
ETF 2
XHE

SPDR S&P Health Care Equipment ETF

This fund is part of
US Health Care
-2%
Full XHE fund page

F/m Emerald Life Sciences Innovation ETF (LFSC) belongs to the Life Sciences segment. SPDR S&P Health Care Equipment ETF (XHE) is part of the US Health Care segment. LFSC's top 3 sector exposures are Health Care and Sovereign. In contrast, XHE's top sector exposures are Health Care  LFSC is more expensive with a Total Expense Ratio (TER) of 0.79%, versus 0.35% for XHE. LFSC is down -7.57% year-to-date (YTD) with +$5M in YTD flows. XHE performs worse with -9.43% YTD performance, and -$6M in YTD flows. Run a side-by-side ETF comparison of LFSC and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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LFSC vs XHE performance and flow charts

Performance

-6.0-4.0-2.00.02.04.06.0%Feb 12Feb 20Feb 27Mar 6

Cumulative Flows

-2 M0 M2 M4 M6 M8 MFeb 12Feb 20Feb 27Mar 6

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 03/12/2026
1M3MYTD1Y3Y5Y
Perf.
LFSC
XHE
-5.12%-4.50%
-13.36%-10.55%
-7.57%-9.43%
+48.56%-3.01%
n/a-9.90%
n/a-33.44%
Flows
LFSC
XHE
+$6M-$2M
+$6M-$9M
+$5M-$6M
+$16M-$46M
--$297M
--$432M
Volatility and drawdown
3M1Y3Y5Y
Volatility
LFSC
XHE
+22.88%+19.72%
+28.76%+23.64%
n/a+21.12%
n/a+24.20%
Max drawdown
LFSC
XHE
-13.77%-14.50%
-19.03%-14.50%
n/a-32.63%
n/a-49.90%
Max drawdown duration
LFSC
XHE
77d63d
70d63d
n/a1054d
n/a1652d
Trading data

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LFSC
XHE
Last sale
3/13/2026 at 1:30 PM
$33.57
$79.38
Previous close
03/12/2026
$33.82
$79.80
Consolidated volume
03/12/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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LFSC
is actively managed and doesn’t replicate an index

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LFSC
XHE
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/13/2026 at 1:30 PM
Live
Closed
LFSC
XHE
Last price
$33.57
$79.38
1D performance
-0.74%
-0.53%
AuM$90.59 M$133.70 M
E/R0.79%0.35%
Characteristics
LFSC
XHE
Management strategyActivePassive
ProviderEmerald GroupSPDR
Benchmark-S&P Health Care Equipment Select Industry Index
N° of holdings3461
Asset class-Equities
Trailing 12m distribution yield
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Inception dateOctober 31, 2024January 26, 2011
ESGNoNo
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Exposure

Countries

LFSC
USA
88.44%
Other
11.56%
XHE
USA
92.71%
Other
7.29%

Sectors

LFSC
Health Care
86.26%
Other
13.74%
XHE
Health Care
93.87%
Other
6.13%
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Diversification

LFSC

Total weight of top 15 holdings out of 15

68.94%
XHE

Total weight of top 15 holdings out of 15

30.47%

Top 15 holdings

Data as of January 31, 2026
LFSC
COGENT BIOSCIENCES
9.06%
LIVANOVA
6.76%
GUARDANT HEALTH INC
5.62%
MIRUM PHARMACEUTICALS INC
5.37%
TRANSMEDICS GROUP
5.18%
WAVE LFE SCIEN
4.81%
TRAVERE THERAPEUTICS INC
4.77%
BRIDGEBIO PHARMA
3.92%
SAVARA INC
3.82%
ICU MEDICAL
3.60%
KALVISTA PHARMACEUTICALS INC
3.59%
UTD THERAPEUT
3.56%
US00773J2024
3.44%
MADRIGAL PHARMACEUTICALS INC
2.86%
ACADIA PHARMACEUTICALS
2.58%
XHE
NEOGEN
2.63%
INTEGER HOLDINGS
2.17%
PENUMBRA
2.12%
UFP TECHNOLOGY
2.11%
AXOGEN
2.09%
OMNICELL
1.98%
LANTHEUS HOLDINGS
1.98%
BAXTER INTL
1.98%
GLAUKOS
1.97%
DEXCOM
1.94%
DENTSPLY SIRONA
1.92%
BUTTERFLY NETWORK INC
1.92%
ENVISTA HOLDINGS CORP
1.91%
STRYKER
1.88%
GLOBUS MEDICAL
1.86%
Frequently asked questions about LFSC and XHE

How have the LFSC and XHE ETFs performed in 2026?

As of March 12, 2026, LFSC is down -7.57% year-to-date (YTD), while XHE has lost -9.43%. That puts LFSC better performer ahead so far this year.

Which ETF is attracting more investor money: LFSC or XHE?

Year-to-date, the LFSC ETF saw +$5M in flows, compared to -$6M for XHE.

Which ETF is more volatile: LFSC or XHE?

Over the past year, LFSC had a volatility of 28.76%, while XHE experienced 23.64%.

Which ETF is bigger: LFSC or XHE?

As of March 12, 2026, LFSC holds $90.59 M in assets under management (AUM), while XHE manages $133.70 M.

What sectors do the LFSC and XHE ETFs invest in?

LFSC leans toward sectors like Health Care. Meanwhile, XHE focuses on Health Care.

What are the top holdings of the LFSC ETF and XHE ETF?

LFSC top holdings include COGENT BIOSCIENCES, LIVANOVA and GUARDANT HEALTH INC. XHE holds in its top three: NEOGEN, INTEGER HOLDINGS and PENUMBRA.

Which ETF is more diversified: LFSC or XHE?

LFSC holds 42 securities with 68.94% of its assets in the top 15. XHE has 64 securities and a top 15 weight of 30.47%.

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