IYHvsXLVIETF Comparison
VS
ETF 2
XLVI
State Street Health Care Select Sector SPDR Premium Income Fund
This fund is part of
Options Strategies
-0.18%
iShares U.S. Healthcare ETF (IYH) belongs to the US Health Care segment. State Street Health Care Select Sector SPDR Premium Income Fund (XLVI) is part of the Options Strategies segment. Both ETFs have the same top 3 sector exposures: and Health Care. IYH is more expensive with a Total Expense Ratio (TER) of 0.38%, versus 0.35% for XLVI. IYH is up 0.08% year-to-date (YTD) with -$380M in YTD flows. XLVI performs better with 2.13% YTD performance, and +$4M in YTD flows. Run a side-by-side ETF comparison of IYH and XLVI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IYH vs XLVI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/09/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IYH XLVI | +7.86%+6.44% | +1.05%+1.06% | +0.08%+2.13% | +16.94%n/a | +22.82%n/a | +29.13%n/a |
| Flows | IYH XLVI | +$210M+$2M | +$93M+$2M | -$380M+$4M | -$18M- | -$499M- | +$42M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IYH XLVI | +16.59%+13.59% | +15.14%n/a | +14.19%n/a | +14.99%n/a |
| Max drawdown | IYH XLVI | -6.72%-6.06% | -10.72%n/a | -17.89%n/a | -17.89%n/a |
| Max drawdown duration | IYH XLVI | 91d86d | 153dn/a | 445dn/a | 445dn/a |
Trading data
IYH | XLVI | |
Last sale 6/10/2026 at 1:30 PM | $64.09 | $25.50 |
| Previous close 06/09/2026 | $64.93 | $25.60 |
| Consolidated volume 06/09/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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XLVI
is actively managed and doesn’t replicate an indexIYH | XLVI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/10/2026 at 1:30 PM
Live
Closed
IYH | XLVI | |
|---|---|---|
| Last price | $64.09 | $25.50 |
| 1D performance | -1.29% | -0.38% |
| AuM | $3.19 B | $14.84 M |
| E/R | 0.38% | 0.35% |
Characteristics
IYH | XLVI | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | iShares | State Street Investment Management |
| Benchmark | Russell 1000 Health Care RIC 22.5/45 Capped Gross Index | - |
| N° of holdings | 94 | 55 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 12, 2000 | July 30, 2025 |
| ESG | No | No |
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Exposure
Countries
IYH
USA
96.67%
Other
3.33%
XLVI
USA
96.67%
Other
3.33%
Sectors
IYH
Health Care
97.93%
Other
2.07%
XLVI
Health Care
97.69%
Other
2.31%
Diversification
IYH
Total weight of top 15 holdings out of 15
68.52%
XLVI
Total weight of top 15 holdings out of 15
70.39%
Top 15 holdings
Data as of April 30, 2026
IYH
LILLY
13.72%
JOHNSON&JOHNSON
10.14%
ABBVIE
6.86%
UNITEDHEALTH GRP
6.18%
MERCK & CO INC
4.97%
AMGEN-T
3.41%
THERMO FISHER SCIENTIFIC
3.32%
GILEAD SCIENCES
2.99%
INTUITIVE SURGICAL
2.96%
ABBOTT LABS
2.88%
PFIZER
2.78%
BRISTOL-MYERS SQUIBB
2.26%
DANAHER
2.07%
STRYKER
1.99%
VERTEX PHARMACEUTICALS
1.99%
XLVI
LILLY
13.98%
JOHNSON&JOHNSON
10.46%
ABBVIE
7.05%
UNITEDHEALTH GRP
6.34%
MERCK & CO INC
5.12%
AMGEN-T
3.52%
THERMO FISHER SCIENTIFIC
3.40%
INTUITIVE SURGICAL
3.07%
GILEAD SCIENCES
3.06%
ABBOTT LABS
2.98%
PFIZER
2.87%
BRISTOL-MYERS SQUIBB
2.33%
DANAHER
2.13%
VERTEX PHARMACEUTICALS
2.05%
STRYKER
2.05%
Frequently asked questions about IYH and XLVI
How have the IYH and XLVI ETFs performed in 2026?
As of June 9, 2026, IYH is up 0.08% year-to-date (YTD), while XLVI has returned 2.13%. That puts XLVI better performer ahead so far this year.
Which ETF is attracting more investor money: IYH or XLVI?
Year-to-date, the IYH ETF saw -$380M in flows, compared to +$4M for XLVI.
Which ETF is bigger: IYH or XLVI?
As of June 9, 2026, IYH holds $3.19 B in assets under management (AUM), while XLVI manages $14.84 M.
What sectors do the IYH and XLVI ETFs invest in?
IYH leans toward sectors like Health Care. Meanwhile, XLVI focuses on Health Care.
What are the top holdings of the IYH ETF and XLVI ETF?
IYH top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. XLVI holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.
Which ETF is more diversified: IYH or XLVI?
IYH holds 104 securities with 68.52% of its assets in the top 15. XLVI has 58 securities and a top 15 weight of 70.39%.
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Latest news about IYH & XLVI
Health Care Sector Down After a Cyberattack on UnitedHealth
March 4, 2024
IYH
Healthcare Stocks Rebound
August 14, 2023
IYH
Continued tightening of the U.S. labor market
September 23, 2022
IYH
U.S. labor market facing tight conditions
July 5, 2022
IYH
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