IDNAvsPBEETF Comparison
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iShares Genomics Immunology and Healthcare ETF (IDNA) and Invesco Dynamic Biotechnology & Genome ETF (PBE) belong to the same industry segment: BioTech & Genomics. Both ETFs have the same top 3 sector exposures: and Health Care. IDNA is less expensive with a Total Expense Ratio (TER) of 0.47%, versus 0.58% for PBE. IDNA is up 12.73% year-to-date (YTD) with +$15M in YTD flows. PBE performs worse with 3.34% YTD performance, and -$3M in YTD flows. Run a side-by-side ETF comparison of IDNA and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IDNA vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IDNA PBE | -0.86%+2.80% | -1.11%+8.31% | +12.73%+3.34% | +40.58%+32.63% | +24.39%+36.02% | -38.03%+11.22% |
| Flows | IDNA PBE | +$1M+$2M | +$11M-$3M | +$15M-$3M | +$9M-$26M | -$9M-$56M | +$14M-$45M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IDNA PBE | +25.75%+20.51% | +23.78%+19.07% | +24.15%+20.14% | +27.94%+22.41% |
| Max drawdown | IDNA PBE | -8.84%-4.08% | -10.60%-11.70% | -29.86%-22.21% | -68.19%-34.74% |
| Max drawdown duration | IDNA PBE | 53d16d | 46d155d | 258d324d | 1726d1540d |
Trading data
IDNA | PBE | |
Last sale 6/12/2026 at 1:30 PM | $29.77 | $84.10 |
| Previous close 06/11/2026 | $29.52 | $84.82 |
| Consolidated volume 06/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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IDNA | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/12/2026 at 1:30 PM
Live
Closed
IDNA | PBE | |
|---|---|---|
| Last price | $29.77 | $84.10 |
| 1D performance | +0.85% | -0.85% |
| AuM | $162.34 M | $261.88 M |
| E/R | 0.47% | 0.58% |
Characteristics
IDNA | PBE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | Invesco |
| Benchmark | NYSE FactSet Global Genomics and Immuno Biopharma Index | Dynamic Biotech & Genome Intellidex Index |
| N° of holdings | 40 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 11, 2019 | June 23, 2005 |
| ESG | No | No |
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Exposure
Countries
IDNA
USA
62.06%
France
9.25%
Other
28.69%
PBE
USA
92.2%
Other
7.8%
Sectors
IDNA
Health Care
89.66%
Other
10.34%
PBE
Health Care
97.78%
Other
2.22%
Diversification
IDNA
Total weight of top 15 holdings out of 15
65.52%
PBE
Total weight of top 15 holdings out of 15
62.95%
Top 15 holdings
Data as of April 30, 2026
IDNA
REVOLUTION MEDICINES INC
6.86%
MODERNA INC
6.28%
IPSEN PROMESSES
5.23%
TAKEDA PHARMACEUTICAL
4.49%
BAYER AG
4.36%
MERCK & CO INC
4.15%
GSK PLC
4.12%
BIONTECH SE ADR
4.07%
CH1499059983
3.99%
EXELIXIS
3.80%
TWIST BIOSCIENCE CORP
3.79%
REGENERON PHARMACEUTICALS
3.73%
SANOFI SA
3.58%
VERTEX PHARMACEUTICALS
3.56%
INCYTE
3.52%
PBE
UTD THERAPEUT
6.20%
ILLUMINA
5.42%
REGENERON PHARMACEUTICALS
4.99%
INCYTE
4.91%
ALNYLAM PHARMACEUTICALS
4.80%
BIOGEN INC
4.80%
AMGEN-T
4.60%
GILEAD SCIENCES
4.48%
CATALYST PHARMACEUTICALS INC
3.42%
BIOCRYST PHARMACEUTICALS
3.30%
TG THERAPEUTICS
3.28%
ARROWHEAD PHARMACEUTICALS INC
3.27%
CAREDX INC/D
3.21%
PROTAGONIST THERAPEUTICS INC
3.18%
ROYALTY PHARMA
3.09%
Frequently asked questions about IDNA and PBE
How have the IDNA and PBE ETFs performed in 2026?
As of June 11, 2026, IDNA is up 12.73% year-to-date (YTD), while PBE has returned 3.34%. That puts IDNA better performer ahead so far this year.
Which ETF is attracting more investor money: IDNA or PBE?
Year-to-date, the IDNA ETF saw +$15M in flows, compared to -$3M for PBE.
Which ETF is more volatile: IDNA or PBE?
Over the past year, IDNA had a volatility of 23.78%, while PBE experienced 19.07%.
Which ETF is bigger: IDNA or PBE?
As of June 11, 2026, IDNA holds $162.34 M in assets under management (AUM), while PBE manages $261.88 M.
What sectors do the IDNA and PBE ETFs invest in?
IDNA leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.
What are the top holdings of the IDNA ETF and PBE ETF?
IDNA top holdings include REVOLUTION MEDICINES INC, MODERNA INC and IPSEN PROMESSES. PBE holds in its top three: UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS.
Which ETF is more diversified: IDNA or PBE?
IDNA holds 50 securities with 65.52% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 62.95%.
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