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IDNAvsIBBQETF Comparison

ETF 1

IDNA

iShares Genomics Immunology and Healthcare ETF

This fund is part of

BioTech & Genomics

+0.3%

Full IDNA fund page

VS

ETF 2

IBBQ

Invesco Nasdaq Biotechnology ETF

This fund is part of

US Health Care

-1.03%

Full IBBQ fund page

iShares Genomics Immunology and Healthcare ETF (IDNA) belongs to the BioTech & Genomics segment. Invesco Nasdaq Biotechnology ETF (IBBQ) is part of the US Health Care segment. IDNA's top 2 sector exposures are Healthcare and Non-Corporate. In contrast, IBBQ's top sector exposures are Healthcare and Non-Energy Materials. IDNA is more expensive with a Total Expense Ratio (TER) of 0.47%, versus 0.19% for IBBQ. IDNA is up 56.97% year-to-date (YTD) with +$107M in YTD flows. IBBQ performs worse with 22.86% YTD performance, and +$38M in YTD flows. Run a side-by-side ETF comparison of IDNA and IBBQ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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IDNA vs IBBQ performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 10/23/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	IDNA IBBQ	+0.71%-0.34%	+26.25%+7.21%	+56.97%+22.86%	+68.01%+36.10%	+137.40%+90.27%	-14.00%+44.83%
Flows	IDNA IBBQ	+$44M+$14M	+$78M+$35M	+$107M+$38M	+$106M+$56M	+$84M+$74M	+$64M+$52M

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	IDNA IBBQ	+40.06%+25.52%	+29.07%+22.48%	+26.03%+21.25%	+28.83%+22.22%
Max drawdown	IDNA IBBQ	-8.56%-8.58%	-10.60%-8.58%	-29.33%-23.78%	-65.57%-34.86%
Max drawdown duration	IDNA IBBQ	27d65d	46d65d	347d375d	1815d1429d

Trading data

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	IDNA	IBBQ
Last sale 10/23/2026 at 1:30 PM	$40.91	$34.52
Previous close 10/22/2026	$41.04	$34.92
Consolidated volume 10/22/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of September 30, 2026

1-year trailing difference

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	IDNA	IBBQ
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 10/23/2026 at 1:30 PM

Live

Closed

	IDNA	IBBQ
Last price	$40.91	$34.52
1D performance	-0.32%	-1.15%
AuM	$321.28 M	$115.07 M
E/R	0.47%	0.19%

Characteristics

	IDNA	IBBQ
Management strategy	Passive	Passive
Provider	iShares	Invesco
Benchmark	NYSE FactSet Global Genomics and Immuno Biopharma Index	NASDAQ Biotechnology Index
N° of holdings	48	249
Asset class	Equities	Equities
Trailing 12m distribution yield	Join	Join
Inception date	June 11, 2019	June 9, 2021
ESG	No	No

More IDNA data on Trackinsight

More IBBQ data on Trackinsight

Exposure

Countries

IDNA

USA

63.78%

Germany

7.53%

Other

28.69%

IBBQ

USA

88.22%

Other

11.78%

Sectors

IDNA

Healthcare

99.75%

Other

0.25%

IBBQ

Healthcare

99.99%

Other

0.01%

Diversification

IDNA

Total weight of top 15 holdings out of 15

61.2%

IBBQ

Total weight of top 15 holdings out of 15

52.06%

Top 15 holdings

Data as of August 31, 2026

IDNA

Moderna, Inc.

8.85%

Twist Bioscience Corp.

6.01%

Revolution Medicines, Inc.

4.12%

Bayer AG

4.08%

Genmab A/S

4.00%

Regeneron Pharmaceuticals, Inc.

3.76%

Merck & Co., Inc.

3.66%

Vertex Pharmaceuticals, Inc.

3.65%

Incyte Corp.

3.60%

Takeda Pharmaceutical Co., Ltd.

3.51%

BioNTech SE

3.45%

Roche Holding AG

3.17%

IDEAYA Biosciences, Inc.

3.13%

Ipsen SA

3.11%

Exelixis, Inc.

3.10%

IBBQ

Amgen, Inc.

8.60%

Vertex Pharmaceuticals, Inc.

8.10%

Gilead Sciences, Inc.

7.34%

Regeneron Pharmaceuticals, Inc.

5.26%

Moderna, Inc.

3.58%

Revolution Medicines, Inc.

2.97%

Illumina, Inc.

2.18%

Biogen, Inc.

2.07%

Alnylam Pharmaceuticals, Inc.

2.00%

argenx SE

1.84%

Royalty Pharma Plc

1.73%

Roivant Sciences Ltd.

1.71%

Insmed, Inc.

1.66%

Incyte Corp.

1.61%

United Therapeutics Corp.

1.42%

Frequently asked questions about IDNA and IBBQ

How have the IDNA and IBBQ ETFs performed in 2026?

As of October 23, 2026, IDNA is up 56.97% year-to-date (YTD), while IBBQ has returned 22.86%. That puts IDNA better performer ahead so far this year.

Which ETF is attracting more investor money: IDNA or IBBQ?

Year-to-date, the IDNA ETF saw +$107M in flows, compared to +$38M for IBBQ.

Which ETF is more volatile: IDNA or IBBQ?

Over the past year, IDNA had a volatility of 29.07%, while IBBQ experienced 22.48%.

Which ETF is bigger: IDNA or IBBQ?

As of October 23, 2026, IDNA holds $321.28 M in assets under management (AUM), while IBBQ manages $115.07 M.

What sectors do the IDNA and IBBQ ETFs invest in?

IDNA leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.

What are the top holdings of the IDNA ETF and IBBQ ETF?

IDNA top holdings include Moderna, Inc., Twist Bioscience Corp. and Revolution Medicines, Inc.. IBBQ holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc..

IDNAvsIBBQETF Comparison

iShares Genomics Immunology and Healthcare ETF

Invesco Nasdaq Biotechnology ETF

IDNA vs IBBQ performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the IDNA and IBBQ ETFs performed in 2026?

As of October 23, 2026, IDNA is up 56.97% year-to-date (YTD), while IBBQ has returned 22.86%. That puts IDNA better performer ahead so far this year.

Which ETF is attracting more investor money: IDNA or IBBQ?

Year-to-date, the IDNA ETF saw +$107M in flows, compared to +$38M for IBBQ.

Which ETF is more volatile: IDNA or IBBQ?

Over the past year, IDNA had a volatility of 29.07%, while IBBQ experienced 22.48%.

Which ETF is bigger: IDNA or IBBQ?

As of October 23, 2026, IDNA holds $321.28 M in assets under management (AUM), while IBBQ manages $115.07 M.

What sectors do the IDNA and IBBQ ETFs invest in?

IDNA leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.

What are the top holdings of the IDNA ETF and IBBQ ETF?

IDNA top holdings include Moderna, Inc., Twist Bioscience Corp. and Revolution Medicines, Inc.. IBBQ holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc..

Which ETF is more diversified: IDNA or IBBQ?

IDNA holds 48 securities with 61.2% of its assets in the top 15. IBBQ has 249 securities and a top 15 weight of 52.06%.

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